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Rowland to Appear on CBS's Sunday Morning
On Sunday, November 28, Dr. Julia Rowland, director of NCI's Office of Cancer
Survivorship, is scheduled to appear on the CBS news program Sunday Morning.
She was interviewed for a 10-minute segment on survivorship, reported by senior
correspondent Martha Teichner. The segment will appear after 9:00 a.m. EST.
Rowland said of the experience, "It was an incredible opportunity to
participate in the survivorship dialogue that's been in the press in recent
months. Our office was established 8 years ago, yet most Americans don't know
it exists. We want survivors and their families to know that we're making their
issues a critical part of the national cancer program. Through research and
application, we must ensure that all survivors are offered hope for a full and
meaningful life after cancer."
In addition to Dr. Rowland, several cancer specialists and advocates are
scheduled to appear on the program, including Lance Armstrong, six-time Tour de
France winner and member of the Presidents' Cancer Panel, and Ellen Stovall,
President and CEO of the National Coalition for Cancer Survivorship. Sunday
Morning is seen by 5 million viewers.
Waldmann Lectures on Role of IL-2 and IL-15 in Immunotherapy
Abnormal cells overexpress receptors for IL-2 and IL-15 cytokines, creating an
excellent opportunity for targeted treatment and prevention of cancer and other
immunologic diseases, said Dr. Thomas Waldmann, chief of the Metabolism Branch
at NCI's Center for Cancer Research, during his Grand Rounds lecture on
November 9. The IL-2 receptor blocker daclizumab (Zenapax), is already being
used in humans to prevent organ transplant rejection, and has shown promise in
mice as a treatment for advanced T-cell lymphoma. The more recently discovered
IL-15 and its receptor pose other opportunities for targeted therapy. IL-15 in
vaccines may be superior to IL-2, Dr. Waldmann said, particularly for diseases
such as cancer, HIV, tuberculosis, malaria, and anthrax, where long-term
response is needed. He also noted that agents targeting the IL-2/IL-15 system
hold great promise for people with leukemia, lymphoma, rheumatoid arthritis,
psoriasis, and other autoimmune diseases.
ASCO Issues Clinical Recommendations on Aromatase Inhibitors
The American Society of Clinical Oncology (ASCO) has issued an updated
technology assessment stating that aromatase inhibitors are appropriate to use
as adjuvant therapy for postmenopausal women with hormone receptor-positive
breast cancer to lower the risk of tumor recurrence. The assessment, which
focused on anastrozole, letrozole, and exemestane, was published online at
http://www.jco.org on Nov. 15, ahead of print in the Journal of Clinical
Oncology.
This new technology assessment updates ASCO's previous recommendation
on adjuvant hormonal therapy for this patient group. These new recommendations,
based on results from multiple large randomized trials, indicate that aromatase
inhibitors can be used either following initial adjuvant treatment with
tamoxifen or as initial treatment. Options include treatment with tamoxifen for
2 to 5 years, followed by treatment with aromatase inhibitors, or treatment for
5 years with an aromatase inhibitor alone.
"Many practicing oncologists have
incorporated aromatase inhibitors into their standard practice," explains Dr.
Jo Anne Zujewski, senior investigator in NCI's Clinical Trials Evaluation
Program. "This update signifies that there is agreement that aromatase
inhibitors are now considered standard therapy for these patients."
A patient
version of the clinical practice recommendations is available online at
http://www.PLWC.org.
FDA Approves Tarceva for Non-Small-Cell Lung Cancer
After fast-track review, the FDA has approved Tarceva (erlotinib) for treatment
of locally advanced or metastatic non-small-cell lung cancer. The drug, which
targets the EGFR1 pathway, is recommended once a day for patients who have
failed to improve after at least one prior chemotherapy regimen. The FDA based
its approval on results from a randomized phase III trial in which patients
receiving Tarceva had a median survival that was 42.5 percent higher than
patients who received a placebo - the first time that an EGFR-targeted therapy
has gone beyond shrinking tumors to show a survival effect. A year after
treatment, 31.2 percent of patients receiving Tarceva were still alive,
compared with 21.5 percent of patients who had received placebo. In addition,
Tarceva has fewer side effects (the most common being rash and diarrhea) than
most other chemotherapeutic agents.
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