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The Cardiovascular Health Study (CHS) is an NHLBI-funded observational study of
risk factors for cardiovascular disease in adults 65 years or older. Starting
in 1989, and continuing through 1999, participants underwent annual extensive
clinical examinations. Measurements included traditional risk factors such as
blood pressure and lipids as well as measures of subclinical disease, including
echocardiography of the heart, carotid ultrasound, and cranial
magnetic-resonance imaging (MRI). At six month intervals between clinic visits,
and once clinic visits ended, participants were contacted by phone to ascertain
hospitalizations and health status. The main outcomes are coronary heart
disease (CHD), angina, heart failure (HF), stroke, transient ischemic attack
(TIA), claudication, and mortality. Participants continue to be followed for
these events. To date, more than 400 research papers from CHS have been
published and more than 120 ancillary studies are ongoing or complete.
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Principal Investigators and Study Sites
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