Clinical Study of Intermittent Positive Pressure
Breathing (IPPB)
Objectives:
To evaluate the efficacy of long-term intermittent
positive pressure breathing (IPPB) treatment when used as an adjunct to the
overall care of ambulatory outpatients with chronic obstructive pulmonary
disease. The evaluation compared the use of IPPB with use of a powered
nebulizer.
Background
Design:
Multicenter randomized controlled clinical trial.
Criteria for inclusion: Men and women, ages 30 to 74, who were ambulatory and
had symptomatic chronic bronchitis or emphysema.
Results:
Compliance with treatment, lung function, and quality
of life were evaluated at regular intervals during follow-up, and records were
kept of hospitalizations and vital status. Treatment compliance was less than
optimal; only half of the patients used their devices for the prescribed amount
of time or 10 minutes at least three times a day. Although this was
disappointing, it was probably the best compliance that could be attained.
There was no statistically significant difference between the treatment groups
in mortality, rate and duration of hospitalizations, or change in lung function
or life quality with time, overall or for clinically relevant subgroups. The
trial group saw no advantage of IPPB over compressor nebulizer therapy and
concluded that, if an advantage existed, it must be marginal.
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Study Website |
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Study Documentation |
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Data Distribution Agreement |
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