![Testing Information Testing Information](https://webarchive.library.unt.edu/eot2008/20090131002541im_/http://ntp.niehs.nih.gov/images/template/subMastHead_testingInformation.gif)
Nominations to the Testing Program
Nominations to the Testing Program
Home » Testing Information » Nominations to the Testing Program » Nominations in Review 2004
Substances for Which No Study is Recommended at this Time
* Note: A recommendation for "toxicological characterization" in this table includes studies for genotoxicity, subchronic toxicity, and chronic toxicity/carcinogenicity, as determined to be appropriate during the conceptualization and design of a research program to address toxicological data needs. Though other types of studies (e.g. metabolism and disposition, immunotoxicity, reproductive/developmental toxicity) may be conducted as part of a complete toxicological characterization, these types of studies are not listed unless they were specifically recommended.
For information, questions or comments, contact:
Dr. Scott A. Masten
Office of Chemical Nomination and Selection
Environmental Toxicology Program
National Institute of Environmental Health Sciences
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Bitter orange extract [No CAS No.] |
Private Individual | Consumer exposure through increasing dietary supplement use; suspicion of toxicity; lack of adequate toxicity data |
Developmental toxicity:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
n-Butyl glycidyl ether [2426-08-6] |
National Institute of Environmental Health Sciences | Suspicion of toxicity based on structural features; positive results in genetic toxicity studies; substantial potential for human exposure and a lack of chronic toxicity data |
Toxicological studies:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Di-(2-ethylhexyl)phthalate [117-81-7] |
U.S. Food and Drug Administration | Long-term risks associated with medical exposures of infants to DEHP have not been clearly elucidated; significant knowledge gaps on the toxicokinetics and effects in fetal and neonatal primates of intravenous DEHP exposure; further studies will better define risks and benefits of utilizing non-DEHP-containing products |
Tiered research program to address:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Ionic liquids
|
University of Alabama Center for Green Manufacturing | Widespread interest as replacements for volatile organic compounds (VOCs) in various applications; lack of toxicity data |
Toxicological studies:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Perfluorinated compounds class study [Multiple CAS Nos.] |
U.S. Environmental Protection Agency | Presumed widespread human exposure; known toxicity of certain class members; insufficient information to assess hazard/risk across entire structural class |
Toxicological studies:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Stachybotrys chartarum [67892-26-6] |
|
Public concern regarding potential non-infectious adverse health effects of fungal exposures in indoor environments; inadequate toxicological data available evaluating potential systemic toxicity from long-term exposure to this organism under relevant exposure scenarios |
Toxicological studies:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Tungsten trioxide and fibrous tungsten suboxides [1314-35-8] |
National Cancer Institute | Important industrial raw materials; one of several metals that may form toxic fibrous "whiskers"; carcinogenic potential of tungsten (vs. cemented tungsten carbide) is not adequately characterized |
Toxicological studies:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Butylparaben [94-26-8] |
National Institute of Environmental Health Sciences | Widespread use in foods, cosmetics, and pharmaceuticals; potential reproductive toxicant; lack of adequate toxicity data |
Defer:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Decane [124-18-5] |
National Cancer Institute | Widespread industrial use and environmental occurrence as air pollutant; suspicion of carcinogenicity but no adequate carcinogenicity study available |
Defer:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Undecane [1120-21-4] |
National Cancer Institute | Widespread industrial use and environmental occurrence as air pollutant; suspicion of carcinogenicity but no adequate carcinogenicity study available |
Defer:
|
Web page last updated on September 09, 2008
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.