Nominations to the Testing Program
Nominations in Review 2004
- Bitter orange extract
- n-Butyl glycidyl ether
- Di-(2-ethylhexyl)phthalate
- Ionic liquids
- Perfluorinated compounds
- Stachybotrys chartarum
- Tungsten trioxide and fibrous tungsten suboxides
Substances for Which No Study is Recommended at this Time
* Note: A recommendation for "toxicological characterization" in this table includes studies for genotoxicity, subchronic toxicity, and chronic toxicity/carcinogenicity, as determined to be appropriate during the conceptualization and design of a research program to address toxicological data needs. Though other types of studies (e.g. metabolism and disposition, immunotoxicity, reproductive/developmental toxicity) may be conducted as part of a complete toxicological characterization, these types of studies are not listed unless they were specifically recommended.
For information, questions or comments, contact:
Dr. Scott A. Masten
Office of Chemical Nomination and Selection
Environmental Toxicology Program
National Institute of Environmental Health Sciences
111 T.W. Alexander Drive
Research Triangle Park, NC
(919) 541-5710 (voice)
(919) 541-3647 (fax)
[ Send Email ]
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Bitter orange extract [No CAS No.] |
Private Individual | Consumer exposure through increasing dietary supplement use; suspicion of toxicity; lack of adequate toxicity data |
Developmental toxicity:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
n-Butyl glycidyl ether [2426-08-6] |
National Institute of Environmental Health Sciences | Suspicion of toxicity based on structural features; positive results in genetic toxicity studies; substantial potential for human exposure and a lack of chronic toxicity data |
Toxicological studies:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Di-(2-ethylhexyl)phthalate [117-81-7] |
U.S. Food and Drug Administration | Long-term risks associated with medical exposures of infants to DEHP have not been clearly elucidated; significant knowledge gaps on the toxicokinetics and effects in fetal and neonatal primates of intravenous DEHP exposure; further studies will better define risks and benefits of utilizing non-DEHP-containing products |
Tiered research program to address:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Ionic liquids
|
University of Alabama Center for Green Manufacturing | Widespread interest as replacements for volatile organic compounds (VOCs) in various applications; lack of toxicity data |
Toxicological studies:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Perfluorinated compounds class study [Multiple CAS Nos.] |
U.S. Environmental Protection Agency | Presumed widespread human exposure; known toxicity of certain class members; insufficient information to assess hazard/risk across entire structural class |
Toxicological studies:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Stachybotrys chartarum [67892-26-6] |
|
Public concern regarding potential non-infectious adverse health effects of fungal exposures in indoor environments; inadequate toxicological data available evaluating potential systemic toxicity from long-term exposure to this organism under relevant exposure scenarios |
Toxicological studies:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Tungsten trioxide and fibrous tungsten suboxides [1314-35-8] |
National Cancer Institute | Important industrial raw materials; one of several metals that may form toxic fibrous "whiskers"; carcinogenic potential of tungsten (vs. cemented tungsten carbide) is not adequately characterized |
Toxicological studies:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Butylparaben [94-26-8] |
National Institute of Environmental Health Sciences | Widespread use in foods, cosmetics, and pharmaceuticals; potential reproductive toxicant; lack of adequate toxicity data |
Defer:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Decane [124-18-5] |
National Cancer Institute | Widespread industrial use and environmental occurrence as air pollutant; suspicion of carcinogenicity but no adequate carcinogenicity study available |
Defer:
|
Substance[CAS No.] | Nominated by | Rationale for Nomination | ICCEC Recommendations |
---|---|---|---|
Undecane [1120-21-4] |
National Cancer Institute | Widespread industrial use and environmental occurrence as air pollutant; suspicion of carcinogenicity but no adequate carcinogenicity study available |
Defer:
|
Web page last updated on September 09, 2008