Pathology Tables for Peer Review
The National Toxicology Program
NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 13 WEEK SUBCHRONIC Facility: Battelle Columbus Laboratory Chemical CAS #: 25812-30-0 Lock Date: 06/12/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 10 | Infiltration Cellular, Mixed Cell | 3 3 2 4 3 3 | 6 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Infiltration Cellular, Mixed Cell | 2 2 2 3 2 2 2 1 3 | 9 2.1| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Inflammation, Chronic | 2 1 3 1 1 1 | 6 1.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | M M M + M M + M M M | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Atrophy | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M + M M M M M + M | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 2 2 3 2 3 | 5 2.4| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 | 1 1.0| Nephropathy | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Mineralization | 2 2 | 2 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 100 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | M + + + + + + + + + | 9 | Depletion Glycogen | 1 1 1 1 1 | 5 1.0| Infiltration Cellular, Mixed Cell | 2 2 2 1 2 2 3 2 2 | 9 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 1 1 1 1 1 | 6 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Preputial Gland | M M + M M M + M M M | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Atrophy | 3 | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | Atrophy | 3 | 1 3.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Atrophy | 2 3 | 2 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 100 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + | 9 | Mineralization | 1 | 1 1.0| Nephropathy | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Depletion Glycogen | 1 1 1 1 | 4 1.0| Infiltration Cellular, Mixed Cell | 2 2 3 2 2 2 2 1 2 | 9 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 1 1 1 2 1 | 6 1.2| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Preputial Gland | M M M M + + + M M | 3 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Atrophy | 3 3 2 | 3 2.7| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | Atrophy | 3 3 2 | 3 2.7| __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Atrophy | 3 3 3 | 3 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 1000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 8 | Nephropathy | 1 1 1 1 | 4 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 6000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Depletion Glycogen | 1 1 1 1 1 1 1 1 | 8 1.0| Infiltration Cellular, Mixed Cell | 2 2 2 2 1 3 2 2 2 | 9 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Inflammation, Chronic | 3 2 1 1 1 1 1 | 7 1.4| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Preputial Gland | M M M M M M M M M | | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Atrophy | 2 3 3 3 1 | 5 2.4| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | Atrophy | 2 3 3 3 1 | 5 2.4| __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Atrophy | 3 3 3 3 1 | 5 2.6| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 6000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 2 | 1 2.0| Nephropathy | 1 1 1 1 1 1 | 6 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 12,000 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Depletion Glycogen | 1 1 1 1 1 1 1 1 1 | 9 1.0| Infiltration Cellular, Mixed Cell | 2 2 1 2 2 2 2 2 3 2 | 10 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + | 9 | Inflammation, Chronic | 1 1 1 2 1 1 1 | 7 1.1| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + | 1 | Degeneration | 2 | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | M M M M M M M M + + | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + | 9 | Atrophy | 3 2 | 2 2.5| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + | 9 | Atrophy | 3 3 | 2 3.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Atrophy | 3 3 2 3 | 4 2.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 12,000 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 | 1 1.0| Nephropathy | 1 1 1 1 | 4 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 24,000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 10 | Infiltration Cellular, Mixed Cell | 4 3 3 2 3 2 3 2 3 | 9 2.8| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Depletion Glycogen | 2 2 3 3 3 3 3 3 3 3 | 10 2.8| Infiltration Cellular, Mixed Cell | 3 2 3 2 3 2 3 2 3 2 | 10 2.5| Inflammation, Chronic | 3 | 1 3.0| Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Inflammation, Chronic | 2 2 3 2 3 4 4 4 3 2 | 10 2.9| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + M + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + M + + | 9 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Preputial Gland | + M M M + + + M M M | 4 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Atrophy | 3 3 3 2 2 | 5 2.6| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 93027-27 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (GEMFIBROZIL) Date: 07/08/99 Route: DOSED FEED Time: 09:59:00 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 24,000 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | Atrophy | 3 3 3 2 3 | 5 2.8| __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Atrophy | 3 3 3 3 3 | 5 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + M + | 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M + M M M M M M M | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 2 2 2 2 | 4 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 2 2 1 2 2 1 1 | 8 1.5| Nephropathy | 2 1 3 2 2 3 2 3 2 2 | 10 2.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Mineralization | 2 3 3 | 3 2.7| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked ------------------------------------------------------------ ---------- END OF REPORT ---------- 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