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1975 - The first 17 CIS contracts are awarded to NCI-designated Cancer Centers
1989 - The first national training on clinical trials is launched, as is the adoption of the first standardized clinical trials search tool that tailors CIS' response to caller
1997 - CIS Spanish call centers are inaugurated
1999 - New contracts are awarded to 14 offices; the CIS Web site is launched; and a new telephone system is implemented
![CIS E-mail Response Representative](https://webarchive.library.unt.edu/eot2008/20090513110544im_/http://www.cancer.gov/images/Documents/33e1090c-bc04-47f3-8aea-5565f40e7ca9/history2.jpg)
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1983 - NCI establishes a CIS toll-free number, 1-800-4-CANCER, replacing the previous 34 local toll-free lines
1996 - The International CIS Group is established, and the CIS e-mail response service for NCI's Web site is launched
2001 - CIS celebrates its 25th anniversary; LiveHelp, an instant-messaging service, is launched
2004 - CIS takes its 10 millionth call
2006 - CIS celebrates its 30th anniversary
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