National Toxicology Program

CASRN: 122-66-7

Formula: C12-H12-N2

Synonyms/Common Names:

• 1,2-DIPHENYLHYDRAZINE (9CI)

Known Uses:

PRECURSOR FOR DYES; PREPARATION OF PHENYLBUTAZONE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C01854) Completed 
  • NTIS No. PB285791  (Peer Review 04/26/1978)
    Citation: Bioassay of Hydrazobenzene for Possible Carcinogenicity (CAS No. 122-66-7)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C01854) Completed 
  • NTIS No. PB285791  (Peer Review 04/26/1978)
    Citation: Bioassay of Hydrazobenzene for Possible Carcinogenicity (CAS No. 122-66-7)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,.007,.423 %/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C01854) Report Complete 
  • TR-092 (NTIS No. PB285791)  (Peer Review 04/26/1978)
    Bioassay of Hydrazobenzene for Possible Carcinogenicity (CAS No. 122-66-7)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Positive 
  • Dose: MR: 0,.008,.03 (AVG), FR: 0,.004,.01 (AVG), MM: 0,.008,.04 (AVG), FM: 0,.004,.04 (AVG) %/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (522990) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (520041) Completed 
  • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Salmonella (NCI)  (CV-355) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escerichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1985) 1-251
  • Salmonella-NCI  Positive 
• Salmonella  (519790) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  •  Positive