Testing Information

Testing Status of Agents at NTP

trans-Cinnamaldehyde

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http://ntp.niehs.nih.gov/go/TS-M88146

CASRN: 14371-10-9

Related: CINNAMALDEHYDE (104-55-2)

Formula: C9-H8-O

Synonyms/Common Names:

  • 2-PROPENAL, 3-PHENYL-, (E)- (9CI)

Known Uses:

NATURALLY OCCURING DERIVATIVE OF CINNAMON BARK, A FLAVORING

Nomination Background

Short-Term Toxicity

  • 2-WEEK (Gavage)  (C56111E) Completed 
    • Rats: F344/N
    • Dose: FEMALE RATS ONLY: 0, 235, 470, 940, 1410 MG/KG/DAY
  • 13-WEEK (Microencapsulation in Feed)  (C56111B) Completed 
    • NTIS No. PB2004-104394  (Peer Review 09/05/2002)
      Citation: Toxicology and Carcinogenesis Studies oftrans-Cinnamaldehyde (Microencapsulated) (CAS No. 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.41, 0.82, 1.65 OR 3.30% OR 4100, 8200, 16500 OR 33000 PPM; 10/SEX/DOSE

Long-Term Carcinogenicity

  • 2-YEAR (Microencapsulation in Feed)  (C56111B) Report Complete 
    • TR-514 (NTIS No. PB2004-104394)  (Peer Review 09/05/2002)
      Toxicology and Carcinogenesis Studies oftrans-Cinnamaldehyde (Microencapsulated) (CAS No. 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0 (UNTREATED), 0 (VEHICLE), 0.1, 0.21, OR 0.41%; 50/SEX/DOSE

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (290481) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Drosophila  (896321) Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Micronucleus  (A19689) Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (B19689) Completed 
    • Mice: B6C3F1
    • Male Inconclusive 
    • Female Negative 
  • Salmonella  (579971) Completed 
    •  Weakly Positive 
  • Salmonella  (816373) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

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Web page last updated on January 22, 2009