Testing Information

Testing Status of Agents at NTP

Turmeric, oleoresin (curcumin)

Print this pageFriendly URL

http://ntp.niehs.nih.gov/go/TS-10105-J

CASRN: 8024-37-1

Related: CURCURMIN (458-37-7)

Formula: C21-H20-O6

Synonyms/Common Names:

  • CURCUMA LONGA OILS
  • CURCUMA OIL
  • Curcumin
  • TURMERIC OIL

Known Uses:

CONDIMENT. COLOR FOR OINTMENTS. (1)

Short-Term Toxicity

  • 13-Week (Dosed-Feed)  (C60015) Completed 
    • NTIS No. PB94-184173  (Peer Review 06/23/1992)
      Citation: Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,.10,5%/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C60015) Report Complete 
    • TR-427 (NTIS No. PB94-184173)  (Peer Review 06/23/1992)
      Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R & M: 0, .2, 1.0, AND 5.0%

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (001566) Completed 
    • Chromosome Aberation Weakly Positive 
    • Sister Chromatid Exchange Weakly Positive 
  • Salmonella  (857432) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • Continuous Breeding (Dosed-Feed)  (RACB85001) Completed 
    • M/F Rats/Mice: F344/N & B6C3F1
    • Dose: 0, 2,000, 10,000, 50,000 PPM IN FEED

Back to top

Web page last updated on January 22, 2009