Primary Sclerosing Cholangitis Conference
Lister Hill Conference Center
NIH Campus Bethesda, MD
September 19-20, 2005
Summary
To assess current knowledge about primary sclerosing cholangitis (PSC) focusing on its prevalence and incidence, diagnosis and staging, pathogenesis, disease associations, management, and treatment, including use of surgery and liver transplantation. The meeting will be sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases, the Office of Rare Diseases, and the Morgan Foundation. The aims of the meeting are to stimulate clinical and basic research interest in PSC and identify gaps in knowledge and challenges for medical research in this disease. The meeting will include poster sessions with noon and evening attendance of speakers, presenters, and participants. The meeting summary will be prepared for publication by members of the organizing committee.Agenda
September 19, 2005
8:30 a.m. - 8:40 a.m. Welcome and Aims Jay Hoofnagle
Session One: Clinical Features and Epidemiology Moderators: Roger Chapman and Jay Hoofnagle
8:40 a.m. - 9:00 a.m. The Clinical Syndrome in Adults Russell Wiesner
9:00 a.m. - 9:20 a.m. The Clinical Syndrome in Children Eva Roberts
9:20 a.m. - 9:40 a.m. Natural History and Survival W. Ray Kim
9:40 a.m. - 10:00 a.m. Epidemiology of PSC K.M. Boberg
10:00 a.m. -10:20 a.m. Discussion Moderators and Speakers
10:20 a.m. - 10:50 a.m. Break
Session Two: Diagnosis Moderators: Keith Lindor and Ben Shneider
10:50 a.m. - 11:10 a.m. Diagnosis in Adults Paul Angulo
11:10 a.m. - 11:30 a.m. Diagnosis in Children Giorgina Mieli-Vergani
11:30 a.m. - 11:50 a.m. Imaging Tests in Diagnosis of PSC Ann S. Fulcher
11:50 a.m. - 12:10 p.m. Pathology of PSC: Diagnosis and Staging Swan Thung
12:10 p.m. - 12:30 p.m. Discussion Moderators and Speakers
12:30 p.m. - 1:30 p.m. Lunch and Posters (boxed lunches will be provided)
Session Three: Pathogenesis Moderators: Giorgina Mieli-Vergani and Dennis Black
1:30 p.m. - 1:50 p.m. The Cholangiopathies and PSC Nicholas LaRusso
1:50 p.m. - 2:10 p.m. Genetics and PSC Peter Donaldson
2:10 p.m. - 2:30 p.m. Animal Models of PSC John Vierling
2:30 p.m. - 2:50 p.m. MDR2 and Other Transporters and PSC Michael Trauner
2:50 p.m. - 3:10 p.m. Discussion Moderators and Speakers
3:10 p.m. - 3:40 p.m. Break
Session Four: Pathogenesis (Continued) Moderators: James Neuberger and Stephen James
3:40 p.m. - 4:00 p.m. Autoimmunity and PSC Roger Chapman
4:00 p.m. - 4:20 p.m. Innate Immunity, NOD-2 and PSC Dan Podolsky
4:20 p.m. - 4:40 p.m. T cell Immunity and PSC David Adams
4:40 p.m. - 5:00 p.m. Discussion Moderators and Speakers
5:00 p.m. - 6:30 p.m. Poster Session September 20, 2005 S
Session Five: Therapy of PSC Moderators: Eve Roberts and Nicholas LaRusso
8:30 a.m. - 8:50 a.m. Medical Management in Adults Marshall Kaplan
8:50 a.m. - 9:10 a.m. Medical Management in Children Ben Shneider
9:10 a.m. - 9:30 a.m. Management of Complications Adolf Stiehl
9:30 a.m. - 9:50 a.m. Endoscopic Therapy Anthony Kalloo
9:50 a.m. - 10:10 a.m. Innovative Approaches Keith Lindor
10:10 a.m. - 10:30 a.m. Discussion Moderators and Speakers
10:30 a.m. - 11:00 a.m. Break
Session Six: Liver Transplantation for PSC Moderators: Russell Wiesner and Ed Doo
11:00 a.m. - 11:20 a.m. Liver Transplantation in Adults Robert Merion
11:20 a.m. - 11:40 a.m. Indications and Timing in Pediatric PSC Estella Alonso
11:40 a.m. - 12:00 noon Pst Tx Complications and Recurrence James Neuberger
12:00 noon - 12:30 p.m. Discussion Moderators and Speakers
12:30 p.m. - 1:30 p.m. Lunch (boxed lunches will be provided)
Session Seven: Cholangiocarcinoma Moderators: John Vierling and Robert Merion
1:30 p.m. - 1:50 p.m. Epidemiology Hashem El-Serag
1:50 p.m. - 2:10 p.m. Clinical Features and Early Diagnosis Naga Chalasani
2:10 p.m. - 2:30 p.m. Pathogenesis Gregory Gores
2:30 p.m. - 2:50 p.m. Liver Transplantation Chris Broelsch
2:50 p.m. - 3:20 p.m. Discussion Moderators and Speakers
3:20 p.m. - 3:50 p.m. Break Session Eight: Synthesis and Future Directions Moderators: TBD
3:50 p.m. - 4:30 p.m. Synthesis and Future Directions Ben
Shneider, Nicholas LaRusso, and Dennis Black
4:30 p.m. Adjourn
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