National Toxicology Program

CASRN: 509-14-8

Formula: C N4 O8

Synonyms/Common Names:

• TNM

Known Uses:

ROCKET PROPELLANTS; ADDITIVE TO DIESEL FUEL; EXPLOSIVE; REAGENT

Short-Term Toxicity

• 14-Day (Inhalation)  (C55947) Completed 
  • NTIS No. PB91-113373  (Peer Review 11/20/1989)
    Citation: Toxicology and Carcinogenesis Studies of Tetranitromethane (CAS No. 509-14-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Inhalation)  (C55947) Completed 
  • NTIS No. PB91-113373  (Peer Review 11/20/1989)
    Citation: Toxicology and Carcinogenesis Studies of Tetranitromethane (CAS No. 509-14-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,.1,10 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C55947) Report Complete 
  • TR-386 (NTIS No. PB91-113373)  (Peer Review 11/20/1989)
    Toxicology and Carcinogenesis Studies of Tetranitromethane (CAS No. 509-14-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: R: 0,2,5, M: 0,0.5,2 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (247313) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Salmonella  (631374) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Positive