NINDS Neuroscience Funding Announcements

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Glial Cell Inflammatory Mechanisms of HIV-1 Induced Cell Injury in the Nervous System
Release Date: March 20, 2003
Announcement Number: PAS-03-084
Application Receipt Date:
May 1, 2003
September 1, 2003
January 2, 2004
May 1, 2004
September 1, 2004
January 2, 2005
May 1, 2005
September 1, 2005
January 2, 2006   

Funding Contact: NINDS Funding
Program Area: Neural Environment

Brief Description:
Inviting applications to promote research into the role of neuroinflammation in the initiation and expansion of cellular injury and death in the context of HIV-1 infection of the central nervous system (CNS). Recent evidence indicates that microglial and astrocytic activation results in the release of excitotoxins, arachidonic acid metabolites, reactive oxygen species, cytokines and chemokines that lead to neurodegeneration and cognitive impairment in HIV-1 infected individuals. The intent of this PAS is to intensify interest and investigator-initiated research, to attract new investigators to this field, and to mobilize interdisciplinary approaches.

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