Summaries & Associations of Study Results
Levels from TR-526 Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF), and 3,3',4,4',5-Pentachlorobiphenyl
Target Organs and Levels of Evidence
NTP Technical Report Number 526
Produced from Chemtrack Database 02/07/06
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| TEF EVALUATION (DIOXIN MIXTURE) TEFDIOXINMIX |
02/17/04 | |
Gavage FEMALE RATS ONLY: 0, (TCDD) 3.3, 7.3, 15.2, OR 33 NG/KG; (PeCDF) 6.6, 14.5, 30.4, OR 66 NG/KG; (PCB 126) 33.3, 73.3, 153, OR 333 NG/KG; 100/DOSE | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| FR: CLEAR EVIDENCE | LIVER: ADENOMA 0/53 1/53 1/53 1/53 11/51 OR CHOLANGIOCARCINOMA 0/53 0/53 2/53 7/53 9/51 | |||
| |
LUNG: CYSTIC KERATINIZING EPITHELIOMA 0/53 0/53 0/53 2/53 20/53 | |||
| MAY HAVE BEEN RELATED: | PANCREAS ACINAR CELL: ADENOMA OR CARCINOMA 0/52 1/53 2/53 2/53 0/51 | |||
| NON-NEOPLASTIC LESIONS: | LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; PIGMENTATION; INFLAMMATION; DIFFUSE FATTY CHANGE; BILE DUCT HYPERPLASIA; OVAL CELL HYPERPLASIA; NODULAR HYPERPLASIA; EOSINOPHILIC FOCUS; CHOLANGIOFIBROSIS; BILE DUCT CYST; NECROSIS; PORTAL FIBROSIS; MIXED CELL FOCUS; TOXIC HEPATOPATHY | |||
| |
LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR; SQUAMOUS METAPLASIA | |||
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PANCREAS: ARTERIAL CHRONIC ACTIVE INFLAMMATION; ACINAR CYTOPLASMIC VACUOLIZATION; ACINAR ATROPHY; CHRONIC ACTIVE INFLAMMATION; DUCT DILATATION | |||
| |
ADRENAL CORTEX: HYPERPLASIA; CYSTIC DEGENERATION; ATROPHY; CYTOPLASMIC VACUOLIZATION | |||
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ORAL MUCOSA: GINGIVAL SQUAMOUS HYPERPLASIA | |||
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UTERUS: SQUAMOUS METAPLASIA | |||
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THYMUS: ATROPHY; SEVERITY OF ATROPHY | |||
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OVARY: CHRONIC ACTIVE INFLAMMATION | |||
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KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY | |||
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HEART: CARDIOMYOPATHY | |||
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BONE MARROW: HYPERPLASIA | |||
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URINARY BLADDER: TRANSITIONAL EPITHELIAL HYPERPLASIA | |||
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MESENTERY: ARTERIAL CHRONIC ACTIVE INFLAMMATION | |||
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THYROID GLAND: FOLLICULAR CELL HYPERTROPHY | |||
Web page last updated on February 10, 2006
