Testing Status of Agents at NTP
Nitrilotriacetic acid trisodium monohydrate
CASRN: 18662-53-8
Formula: C6 H9 N O6.3NA.H2 O
Synonyms/Common Names:
- GLYCINE, N,N-BIS(CARBOXYMETHYL)-, TRISODIUM SALT, MONOHYDRATE (9CI)
- NITRILOTRIACETIC ACID, TRISODIUM SALT, MONOHYDRATE
- NTA TRISODIUM SALT MONOHYDRATE
Known Uses:
DETERGENTS
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C01445B) Completed
- NTIS No. PB266177
(Peer Review 03/25/1977)
Citation: Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic Acid, Trisodium Salt, Monohydrate (Na3-NTA-H2O) for Possible Carcinogenicity (CAS No. 139-13-9) (NTA) (CAS No. 18662-53-8) (Na3-NTA-H2O) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB266177
(Peer Review 03/25/1977)
- 13-WEEK (Dosed-Feed)
(C01445A) Completed
- NTIS No. PB266177
(Peer Review 03/25/1977)
Citation: Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic Acid, Trisodium Salt, Monohydrate (Na3-NTA-H2O) for Possible Carcinogenicity (CAS No. 139-13-9) (NTA) (CAS No. 18662-53-8) (Na3-NTA-H2O) - Rats: F344/N
- NTIS No. PB266177
(Peer Review 03/25/1977)
- 13-Week (Dosed-Feed)
(C01445B) Completed
- NTIS No. PB266177
(Peer Review 03/25/1977)
Citation: Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic Acid, Trisodium Salt, Monohydrate (Na3-NTA-H2O) for Possible Carcinogenicity (CAS No. 139-13-9) (NTA) (CAS No. 18662-53-8) (Na3-NTA-H2O) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,31600, M: 0,21600 PPM/5 PER GROUP
- NTIS No. PB266177
(Peer Review 03/25/1977)
Long-Term Carcinogenicity
- 2-YEAR (Dosed-Feed)
(C01445A) Report Complete
- TR-006 (NTIS No. PB266177)
(Peer Review 03/25/1977)
Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic Acid, Trisodium Salt, Monohydrate (Na3-NTA-H2O) for Possible Carcinogenicity (CAS No. 139-13-9) (NTA) (CAS No. 18662-53-8) (Na3-NTA-H2O) - Rats: F344/N
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Dose: 0,200,2000,20000 PPM/48 PER GROUP
- TR-006 (NTIS No. PB266177)
(Peer Review 03/25/1977)
- 2-Year (Dosed-Feed)
(C01445B) Report Complete
- TR-006 (NTIS No. PB266177)
(Peer Review 03/25/1977)
Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic Acid, Trisodium Salt, Monohydrate (Na3-NTA-H2O) for Possible Carcinogenicity (CAS No. 139-13-9) (NTA) (CAS No. 18662-53-8) (Na3-NTA-H2O) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal
- Female Rats Equivocal
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0,7500,15000, M: 0,2500,5000 PPM/50 PER GROUP
- TR-006 (NTIS No. PB266177)
(Peer Review 03/25/1977)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(696583) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Weakly Positive
- Mouse Lymphoma (NCI)
(G05650) Completed
- Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
- Mouse Lymphoma-NCI Negative
- Mouse Lymphoma (NCI)
(G89169) Completed
- Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
- Mouse Lymphoma-NCI Negative
- Salmonella (NCI)
(N-9211) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Negative
- Salmonella
(051920) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Negative
Web page last updated on January 22, 2009