National Toxicology Program

CASRN: 54-31-9

Formula: C12 H11 CL N2 O5 S

Synonyms/Common Names:

• 5-(AMINOSULFONYL)-4-CHLORO-2-((2-FURANYLMETHYL)AMINO)BENZOIC ACID (9CI)

Known Uses:

DIURETIC IN THE TREATMENT OF EDEMA AND HYPERTENSION. DIURETIC IN VETERINARY MEDICINE. (TDB)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C55936) Completed 
  • NTIS No. PB90-106162  (Peer Review 04/18/1988)
    Citation: Toxicology and Carcinogenesis Studies of Furosemide (CAS No. 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C55936) Completed 
  • NTIS No. PB90-106162  (Peer Review 04/18/1988)
    Citation: Toxicology and Carcinogenesis Studies of Furosemide (CAS No. 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: MR: 0,625,10000, FR&MM: 0,938,15000, FM: 0,1250,20000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 107-WEEK (Dosed-Feed)  (C55936) Report Complete 
  • TR-356 (NTIS No. PB90-106162)  (Peer Review 04/18/1988)
    Toxicology and Carcinogenesis Studies of Furosemide (CAS No. 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Mice: B6C3F1
  • Carcinogenesis Results
  • Male Mice No Evidence 
  • Female Mice Some Evidence 
  • Dose: R: 0,350,700, M: 0,700,1400 PPM/50 PER GROUP
• 2-YEAR (Dosed-Feed)  (C55936) Report Complete 
  • TR-356 (NTIS No. PB90-106162)  (Peer Review 04/18/1988)
    Toxicology and Carcinogenesis Studies of Furosemide (CAS No. 54-31-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N
  • Carcinogenesis Results
  • Male Rats Equivocal Evidence 
  • Female Rats No Evidence 
  • Dose: R: 0,350,700, M: 0,700,1400 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (169457) Completed 
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (219163) Completed 
  • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
  •  Positive 
• Micronucleus  (912768) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (312303) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 
• Salmonella  (A84903) Completed 
  •  Negative