Phase II Study of Treatment Selection Based Upon Tumor Thymidylate Synthase Expression in Previously Untreated Patients With Metastatic Colorectal Cancer
Final eligibility for a clinical trial is determined by the health professionals conducting the trial.
Patients will be randomly assigned (have an equal chance of being placed in one of three treatment groups).
Patients in groups two and three will receive bevacizumab and oxaliplatin as in group one, a 2-hour infusion of leucovorin, and a 2-day continuous infusion of fluorouracil in weeks 1 and 3.
In all groups, treatment may repeat every 4 weeks for as long as benefit is shown.
Patients will be evaluated periodically for 4 years.
If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on
NCI's Web site.
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| U.S.A. |
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| Colorado |
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Aurora |
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| | Aurora Presbyterian Hospital |
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| | Eduardo Pajon, MD | |
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Boulder |
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| | Boulder Community Hospital |
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| | Clinical Trials Office - Boulder Community Hospital | |
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Colorado Springs |
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| | Penrose Cancer Center at Penrose Hospital |
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| | Clinical Trials Office - Penrose Cancer Center | |
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Denver |
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| | CCOP - Colorado Cancer Research Program |
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| | Eduardo Pajon, MD | |
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| | Porter Adventist Hospital |
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| | Eduardo Pajon, MD | |
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| | Presbyterian - St. Luke's Medical Center |
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| | Clinical Trials Office - Presbyterian - St. Luke's Medical Center | |
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| | Rose Medical Center |
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| | Eduardo Pajon, MD | |
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| | St. Anthony Central Hospital |
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| | Eduardo Pajon, MD | |
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| | St. Joseph Hospital |
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| | Eduardo Pajon, MD | |
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Englewood |
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| | Swedish Medical Center |
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| | Eduardo Pajon, MD | |
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Grand Junction |
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| | St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center |
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| | Eduardo Pajon, MD | |
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Greeley |
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| | North Colorado Medical Center |
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| | Eduardo Pajon, MD | |
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Lone Tree |
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| | Sky Ridge Medical Center |
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| | Eduardo Pajon, MD | |
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Longmont |
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| | Hope Cancer Care Center at Longmont United Hospital |
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| | Eduardo Pajon, MD | |
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Loveland |
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| | McKee Medical Center |
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| | Eduardo Pajon, MD | |
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Pueblo |
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| | St. Mary - Corwin Regional Medical Center |
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| | Eduardo Pajon, MD | |
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Thornton |
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| | North Suburban Medical Center |
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| | Eduardo Pajon, MD | |
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Wheat Ridge |
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| | Exempla Lutheran Medical Center |
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| | Clinical Trials Office - Exempla Lutheran Medical Center | |
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| Florida |
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Gainesville |
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| | University of Florida Shands Cancer Center |
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| | Clinical Trials Office - University of Florida Shands Cancer Center | |
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| Illinois |
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Aurora |
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| | Rush-Copley Cancer Care Center |
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| | Kendrith Rowland, MD | |
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Berwyn |
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| | Hematology Oncology Associates of Illinois - Berwyn |
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| | Mary Mulcahy, MD | |
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Chicago |
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| | Hematology and Oncology Associates |
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| | Clinical Trails Office - Hematology and Oncology Associates | |
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| | Robert H. Lurie Comprehensive Cancer Center at Northwestern University |
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| | Clinical Trials Office - Robert H. Lurie Comprehensive Cancer Center at Northwestern University | |
| | Email:
cancer@northwestern.edu |
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| | Saint Joseph Hospital |
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| | Mary Mulcahy, MD | |
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Joliet |
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| | Joliet Oncology-Hematology Associates, Limited - West |
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| | Kendrith Rowland, MD | |
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| | Midwest Center for Hematology/Oncology |
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| | Mary Mulcahy, MD | |
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Libertyville |
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| | North Shore Oncology and Hematology Associates, Limited - Libertyville |
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| | Mary Mulcahy, MD | |
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Naperville |
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| | La Grange Oncology Associates - Geneva |
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| | Mary Mulcahy, MD | |
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Niles |
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| | Cancer Care and Hematology Specialists of Chicagoland - Niles |
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| | Mary Mulcahy, MD | |
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Rockford |
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| | Swedish-American Regional Cancer Center |
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| | Clinical Trials Office - Swedish-American Regional Cancer Center | |
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Skokie |
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| | Hematology Oncology Associates - Skokie |
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| | Mary Mulcahy, MD | |
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Springfield |
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| | Regional Cancer Center at Memorial Medical Center |
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| | Clinical Trials Office - Regional Cancer Center at Memorial Medical Center | |
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Urbana |
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| | Carle Cancer Center at Carle Foundation Hospital |
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| | Clinical Trials Office - Carle Cancer Center | |
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| | CCOP - Carle Cancer Center |
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| | Clinical Trials Office - CCOP - Carle Cancer Center | |
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| Indiana |
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Elkhart |
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| | Elkhart General Hospital |
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| | Bilal Ansari, MD | |
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Indianapolis |
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| | Indiana University Melvin and Bren Simon Cancer Center |
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| | Clinical Trials Office - Indiana University Cancer Center | |
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| | Veterans Affairs Medical Center - Indianapolis |
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| | Patrick Loehrer, MD | |
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| | William N. Wishard Memorial Hospital |
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| | Patrick Loehrer, MD | |
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Kokomo |
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| | Howard Community Hospital |
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| | Bilal Ansari, MD | |
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La Porte |
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| | Center for Cancer Therapy at LaPorte Hospital and Health Services |
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| | Bilal Ansari, MD | |
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Michigan City |
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| | Saint Anthony Memorial Health Centers |
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| | Kendrith Rowland, MD | |
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South Bend |
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| | CCOP - Northern Indiana CR Consortium |
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| | Bilal Ansari, MD | |
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| | Memorial Hospital of South Bend |
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| | Clinical Trials Office - Memorial Hospital of South Bend | |
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| | Saint Joseph Regional Medical Center |
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| | Bilal Ansari, MD | |
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| Iowa |
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Des Moines |
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| | CCOP - Iowa Oncology Research Association |
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| | Roscoe Morton, MD, FACP | |
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| | John Stoddard Cancer Center at Iowa Lutheran Hospital |
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| | Clinical Trials Office - John Stoddard Cancer Center at Iowa Lutheran Hospital | |
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| | John Stoddard Cancer Center at Iowa Methodist Medical Center |
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| | Clinical Trials Office - John Stoddard Cancer Center at Iowa Methodist Medical Center | |
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| | Medical Oncology and Hematology Associates at John Stoddard Cancer Center |
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| | Roscoe Morton, MD, FACP | |
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| | Medical Oncology and Hematology Associates at Mercy Cancer Center |
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| | Roscoe Morton, MD, FACP | |
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| | Mercy Cancer Center at Mercy Medical Center - Des Moines |
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| | Roscoe Morton, MD, FACP | |
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| | Mercy Capitol Hospital |
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| | Roscoe Morton, MD, FACP | |
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Ottumwa |
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| | McCreery Cancer Center at Ottumwa Regional |
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| | Robert Behrens | |
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Sioux City |
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| | Mercy Medical Center - Sioux City |
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| | Donald Wender, MD, PhD | |
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| | Siouxland Hematology-Oncology Associates, LLP |
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| | Donald Wender, MD, PhD | |
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| | St. Luke's Regional Medical Center |
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| | Donald Wender, MD, PhD | |
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| Massachusetts |
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Taunton |
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| | Morton Hospital & Medical Center |
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| | Robert McNamee, MD | |
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| Michigan |
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Kalamazoo |
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| | Borgess Medical Center |
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| | Raymond Lord, MD | |
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| | Bronson Methodist Hospital |
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| | Raymond Lord, MD | |
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| | West Michigan Cancer Center |
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| | Clinical Trials Office - West Michigan Cancer Center | |
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St. Joseph |
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| | Lakeland Regional Cancer Care Center - St. Joseph |
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| | Bilal Ansari, MD | |
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| Minnesota |
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Burnsville |
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| | Fairview Ridges Hospital |
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| | Patrick Flynn, MD | |
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Coon Rapids |
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| | Mercy and Unity Cancer Center at Mercy Hospital |
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| | Patrick Flynn, MD | |
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Edina |
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| | Fairview Southdale Hospital |
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| | Clinical Trials Office - Fairview Southdale Hospital | |
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Fridley |
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| | Mercy and Unity Cancer Center at Unity Hospital |
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| | Patrick Flynn, MD | |
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Maplewood |
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| | Minnesota Oncology Hematology, PA - Maplewood |
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| | Patrick Flynn, MD | |
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Minneapolis |
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| | Virginia Piper Cancer Institute at Abbott - Northwestern Hospital |
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| | Clinical Trials Office - Virginia Piper Cancer Institute | |
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Robbinsdale |
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| | Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center |
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| | Clinical Trials Office - Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center | |
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Saint Louis Park |
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| | CCOP - Metro-Minnesota |
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| | Patrick Flynn, MD | |
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| | Park Nicollet Cancer Center |
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| | Patrick Flynn, MD | |
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Saint Paul |
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| | United Hospital |
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| | Patrick Flynn, MD | |
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Shakopee |
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| | St. Francis Cancer Center at St. Francis Medical Center |
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| | Patrick Flynn, MD | |
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Waconia |
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| | Ridgeview Medical Center |
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| | Patrick Flynn, MD | |
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Woodbury |
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| | Minnesota Oncology Hematology, PA - Woodbury |
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| | Patrick Flynn, MD | |
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| Nebraska |
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Lincoln |
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| | Cancer Resource Center - Lincoln |
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| | Alan Berg, MD | |
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Omaha |
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| | Alegant Health Cancer Center at Bergan Mercy Medical Center |
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| | Clinical Trials Office - Alegant Health Cancer Center at Bergen Mercy Medical Center | |
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| | CCOP - Missouri Valley Cancer Consortium |
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| | Gamini Soori, MD, FACP, FRCP, MBA | |
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| | Creighton University Medical Center |
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| | Clinical Trials Office - Creighton University Medical Center | |
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| | Immanuel Medical Center |
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| | Gamini Soori, MD, FACP, FRCP, MBA | |
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| | UNMC Eppley Cancer Center at the University of Nebraska Medical Center |
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| | Clinical Trials Office - UNMC Eppley Cancer Center at the University of Nebraska Medical Center | |
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| New Jersey |
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Hamilton |
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| | Cancer Institute of New Jersey at Hamilton |
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| | Clinical Trials Office - Cancer Institute of New Jersey at Hamilton | |
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Marlton |
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| | Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton |
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| | Clinical Trials Office - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | |
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New Brunswick |
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| | Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School |
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| | Clinical Trials Office - Cancer Institute of New Jersey | |
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Voorhees |
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| | Fox Chase Virtua Health Cancer Program at Virtua West Jersey |
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| | Michael Entmacher, MD | |
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| Ohio |
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Bellefontaine |
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| | Mary Rutan Hospital |
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| | J. Philip Kuebler, MD, PhD | |
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Canton |
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| | Aultman Cancer Center at Aultman Hospital |
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| | Clinical Trials Office - Aultman Cancer Center at Aultman Hospital | |
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Chillicothe |
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| | Adena Regional Medical Center |
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| | Clinical Trials Office - Adena Regional Medical Center | |
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| |
Columbus |
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| | CCOP - Columbus |
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| | J. Philip Kuebler, MD, PhD | |
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| | Doctors Hospital at Ohio Health |
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| | Clinical Trials Office - Doctors Hospital at Ohio Health | |
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| | Grant Medical Center Cancer Care |
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| | Clinical Trials Office - Grant Medical Center Cancer Care | |
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| | Mount Carmel Health - West Hospital |
|
| | J. Philip Kuebler, MD, PhD | |
|
| | Riverside Methodist Hospital Cancer Care |
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| | Clinical Trials Office - Riverside Methodist Hospital Cancer Care | |
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Delaware |
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| | Grady Memorial Hospital |
|
| | J. Philip Kuebler, MD, PhD | |
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Lancaster |
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| | Fairfield Medical Center |
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| | J. Philip Kuebler, MD, PhD | |
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Lima |
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| | St. Rita's Medical Center |
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| | Clinical Trials Office - St. Rita's Medical Center | |
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| |
Marietta |
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| | Strecker Cancer Center at Marietta Memorial Hospital |
|
| | J. Philip Kuebler, MD, PhD | |
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Newark |
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| | Licking Memorial Cancer Care Program at Licking Memorial Hospital |
|
| | J. Philip Kuebler, MD, PhD | |
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Springfield |
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| | Community Hospital of Springfield and Clark County |
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| | J. Philip Kuebler, MD, PhD | |
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| | Mercy Medical Center |
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| | J. Philip Kuebler, MD, PhD | |
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Westerville |
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| | Mount Carmel St. Ann's Cancer Center |
|
| | J. Philip Kuebler, MD, PhD | |
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Zanesville |
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| | Genesis - Good Samaritan Hospital |
|
| | Clinical Trials Office - Genesis - Good Samaritan Hospital | |
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| Pennsylvania |
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Abington |
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| | Rosenfeld Cancer Center at Abington Memorial Hospital |
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| | Clinical Trials Office - Rosenfeld Cancer Center at Abington Memorial Hospital | |
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| |
Allentown |
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| | Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest |
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| | Eliot Friedman, MD | |
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Bethlehem |
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| | St. Luke's Cancer Network at St. Luke's Hospital |
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| | Sanjiv Agarwala, MD | |
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| |
Hershey |
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| | Penn State Cancer Institute at Milton S. Hershey Medical Center |
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| | Clinical Trials Office - Penn State Cancer Institute at Milton S. Hershey Medical Center | |
| | Email:
CTO@hmc.psu.edu |
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| |
Lewistown |
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| | Lewistown Hospital |
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| | Yixing Jiang | |
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Philadelphia |
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| | Abramson Cancer Center of the University of Pennsylvania |
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| | Clinical Trials Office - Abramson Cancer Center of the University of Pennsylvania | |
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| | Fox Chase Cancer Center - Philadelphia |
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| | Clinical Trials Office - Fox Chase Cancer Center - Philadelphia | |
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Reading |
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| | McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center |
|
| | Clinical Trials Office - McGlinn Family Regional Cancer Center | |
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| |
State College |
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| | Mount Nittany Medical Center |
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| | Yixing Jiang | |
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West Grove |
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| | Jennersville Regional Hospital |
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| | Clinical Trials Office - Jennersville Regional Hospital | |
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| South Dakota |
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Sioux Falls |
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| | Avera Cancer Institute |
|
| | Loren Tschetter, MD | |
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| | Medical X-Ray Center, PC |
|
| | Loren Tschetter, MD | |
|
| | Sanford Cancer Center at Sanford USD Medical Center |
|
| | Clinical Trials Office - Sanford Cancer Center | |
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| Tennessee |
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Chattanooga |
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| | Erlanger Cancer Center at Erlanger Hospital - Baroness |
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| | Clinical Trials Office - Erlanger Cancer Center | |
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| Texas |
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Temple |
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| | CCOP - Scott and White Hospital |
|
| | Lucas Wong, MD | |
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| Wisconsin |
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La Crosse |
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|
| | Gundersen Lutheran Center for Cancer and Blood |
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| | Clinical Trials Office - Gundersen Lutheran Cancer Center | |
| | Email:
cancerctr@gundluth.org |
|
