Summaries & Associations of Study Results
TR-483 Pentachlorophenol, Purified
Target Organs and Levels of Evidence
NTP Technical Report Number 483
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| PENTACHLOROPHENOL, PURIFIED 87-86-5 |
12/10/97 | WOOD PRESERVATIVE, FUNGICIDE, SOIL FUMIGANT FOR TERMITES, PREHARVEST DEFOLIANT, SEED TREATMENT FOR BEANS, PRESERVATIVE FOR PAINT, LEATHER, TEXTILES, INKS, ANTIBACTERIAL AGENT IN DISINFECTANTS & CLEANSERS (HSDB 1990). | Dosed-Feed R: 0, 200, 400, OR 600 PPM; 50/SEX/GROUP - 1000 PPM STOP STUDY (60/SEX) | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | MESOTHELIUM (ABDOMINAL CAVITY/TUNICA VAGINALIS): MESOTHELIOMA 1/50 0/50 2/50 0/50 9/50 (STOP STUDY) | |||
| NASAL CAVITY: CARCINOMA 1/50 3/50 1/50 0/50 5/50 (STOP STUDY) | ||||
| OTHER :CONSIDERATIONS: | THE CONCLUSION OF SE IS BASED ON THE FINDING THAT PENTACHLOROPHENOL CAN BE CARCINOGENIC UNDER SOME CIRCUMSTANCES, AS WAS THE CASE IN THE STOP-STUDY EXPOSURE OF 1,000 PPM FOR ONE YEAR; HOWEVER UNDER STANDARD CONDITIONS, FOR MALE RATS GIVEN DOSES OF 200, 400, OR 600 PPM IN FEED FOR 2 YEARS, THERE WAS NO EVIDENCE OF CARCINOGENIC ACTIVITY. | |||
| FR: NO EVIDENCE | ||||
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