National Toxicology Program

CASRN: 137-09-7

Related: 2,4-DIAMINOPHENOL HYDROCHLORIDE 29849-01-2

Formula: C6-H8-N2-O.2CL-H

Synonyms/Common Names:

• DIANOL

Known Uses:

PHOTOGRAPHIC DEVELOPER. DYEING FURS AND HAIR. ANALYTICAL REAGENT. (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C60026) Completed 
  • NTIS No. PB93-117919  (Peer Review 03/11/1991)
    Citation: NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,4-Diaminophenol Dihydrochloride (CAS NO. 137-09-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C60026) Completed 
  • NTIS No. PB93-117919  (Peer Review 03/11/1991)
    Citation: NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,4-Diaminophenol Dihydrochloride (CAS NO. 137-09-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,.012,.200, M: 0,.005,.075 G/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C60026) Report Complete 
  • TR-401 (NTIS No. PB93-117919)  (Peer Review 03/11/1991)
    NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,4-Diaminophenol Dihydrochloride (CAS NO. 137-09-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice Some Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0,12.5,25, M: 0,19,38 MG/KG/60 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (729737) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Drosophila  (431842) Completed 
  • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive 
• Mouse Lymphoma  (299952) Completed 
  • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
  •  Positive 
• Salmonella  (539410) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive