Testing Status of Agents at NTP
1,3-Butadiene
CASRN: 106-99-0
Formula: C4-H6
Synonyms/Common Names:
- ALPHA,GAMMA-BUTADIENE
Known Uses:
CHEMICAL INTERMEDIATE. MANUFACTURE OF SYNTHETIC RUBBER. PRODUCED FROM PETROLEUM GASES (MERCK 1989)
Short-Term Toxicity
- 13-WEEK (Inhalation)
(C50602B) Completed
- Rats: F344/N
- Dose: R: 0, 200, 625, 2000, OR 6250 PPM M: 0, 625, 1250, 5000, 8000, OR 16000 PPM
Long-Term Carcinogenicity
- 2-YEAR (Inhalation)
(C50602A) Report Complete
- TR-288 (NTIS No. PB85-179646)
(Peer Review 10/28/1983)
Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CAS No. 106-99-0) in B6C3F1 Mice (Inhalation Studies) - Mice: B6C3F1
- Carcinogenesis Results
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: 0,625,1250 PPM/50 PER GROUP
- TR-288 (NTIS No. PB85-179646)
(Peer Review 10/28/1983)
- 2-YEAR (Inhalation)
(C50602C) Report Complete
- TR-434 (NTIS No. PB94-101631)
(Peer Review 11/21/1991)
Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CAS No. 106-99-0) in B6C3F1 Mice (Inhalation Studies) - Mice: B6C3F1
- Carcinogenesis Results
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: 0, 6.25, 20, 62.5, 200, 625 PPM/50 PER GROUP
- TR-434 (NTIS No. PB94-101631)
(Peer Review 11/21/1991)
- 2-YEAR (Inhalation)
(C50602D) Completed
- Citation: Bucher JR, Melnick RL, and Hildebrandt PK. Lack of Carcinogenicity in Mice Exposed Once to High Concentrations of 1,3-Butadiene. J. Nat. Cancer Inst 85: 1866-1867 (1993).
- Mice: B6C3F1
- Dose: MICE ONLY: 0, 1000, 5000, 10000 PPM/60 PER GROUP
Special Studies
- Absorption Disposition Metabolism Elimination (Inhalation)
(S0220) Completed
- Citation: DAHL, A.R., BECHTOLD, W.E., BOND, J.A., HENDERSON, R.F., MAUDERLY, J.L., MUGGENBURG, B.S., DUN, J.D., AND BIRNBAUM, L.S. SPECIES DIFFERENCES IN THE METABOLISM AND DISPOPSITION OF INHALED 1,3-BUTADIENE AND ISOPRENE. ENVIRONMENTAL HLTH PERSPECTIVES, VOL 86, PP. 65-69, 1990
- Rats; Mice; Monkey
- Absorption Disposition Metabolism Elimination (Inhalation)
(S0792) Completed
- Citation: BOND, J.A., DAHL, A.R., HENDERSON, R.F., DUTCHER, J.S., MAUDERLLY, J.L., AND BIRNBAUM, L.S. SPECIES DIFFERENCES IN THE DISPOSITION OF INHALED BUTADIENE. TOXICOLOGY AQND APPLIED PHARMACOLOGY 84, 612-627 (1986)
- M Rats: Sprague Dawley; M Mice: B6C3F1
- Absorption Disposition Metabolism Elimination (Inhalation)
(S0793) Completed
- Citation: BOND, J.A., MARTIN, O.S., BIRNBAUM, L.S., DAHL, A.R., MELNICK, R.L., AND HENDERSON, R.F. METABOLISM OF 1,3-BUTADIENE BY LUNG AND LIVER MICROSOMES OF RATS AND MICE R EPEATEDLY EXPOSED BY INHALATION TO 1,3-BUTADIENE. TOXICOLOGY LETTERS, 44 (1988) 143-151.
- M Rats: Sprague Dawley; M Mice: B6C3F1
- Absorption Disposition Metabolism Elimination (Inhalation)
(S0794) Completed
- Citation: BOND, J.A., DAHL, A.R., HENDERSON, R.F., AND IRNBAUM, L.S. SPECIES DIFFERENCES IN THE DISTRIBUTION OF INHALED BUTADIENE IN TISSUES. AM. IND. HYG. ASSOC. J. (48) 867-872, (1987)
- M Rats: Sprague Dawley; M Mice: B6C3F1
- Absorption Disposition Metabolism Elimination (Inhalation)
(S0795) Completed
- Citation: SABOURIN, P.J., BURKA, L.T., BECHTOLD, W.E., DAHL, A.R., HOOVER, M.D., CHANG, I.Y., AND HENDERSON, R.F. SPECIES DIFFERENCES IN URINARY BUTADIENE METABOLITES; IDENTIFICATION OF 1,2-DIHYDROXY-4- (N-ACETYLCYSTEINYL) BUTANE, A NOVEL METABOLITE OF BUTADIENE CARCINOGENESIS, VOL 13, NO. 9, PP. 1633-1638, 1992
- Rats: F344/N; Rats: Sprague Dawley; Hamsters: Syrian Golden; Monkey; Mice: B6C3F1
- Other (Intraperitoneal Injection)
(S0459) Completed
- Citation: BIRNBAUM, ET.AL., CHARACTERIZATION OF HEMOGLOBIN ADDUCT FORMATION IN MICE & RATS AFTER ADMINISTRATION OF [14C]BUTADIENE OR [14C]ISOPRENE, TOXICOL & APPL PHARM 100:86-95,1989.
- M Rats: Sprague Dawley; M Mice: B6C3F1
- Dose: 1,10,100 OR 1000 UMOL [14C]BUTADIENE
- Toxicokinetic Study (Inhalation)
(S0796) Completed
- Citation: DAHL, A.R., SUN, J.D., BIRNBAUM, L.S., BOND, J.S., GRIFFITH, W.C. JR, MAUDERLY, J.L., MUGGENBURG, B.S., SABOURIN, P.J., AND HENDERSON, R.F. TOXICOKINETICS OF INHALED 1,3-BUTADIENE IN MONKEYS: COMPARISON TO TOXICOKINETICS OF RATS AND MICE. TOXICOLOGY AND APPLIED PHARMACOLOGY 110, 9-19 (1991)
- Monkey; Rats; Mice
Genetic Toxicology
- Chromosome Aberrations
(A74454) Completed
- Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
- Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
- Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
- Mice
- Chromosome Aberrations
(A93093) Completed
- Mice
- Chromosome Aberation Positive
- Drosophila
(950073) Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Mouse Lymphoma
(614566) Completed
- Citation: McGregor, D., Brown, A.G., Cattanach, P., Edwards, I., McBride, D., Riach, C., Shepherd, W., and Caspary, W. Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors. Environ. Molec. Mutagen. Vol. 17 (1991) 122-129
- Negative
- Micronucleus
(A74454) Completed
- Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
- Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
- Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
- Mice: B6C3F1
- Male Positive (Nonstandard Protocol)
- Salmonella
(256166) Completed
- Positive
- Sister Chromatid Exchanges
(A74454) Completed
- Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
- Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
- Citation: Tice, R.R., Boucher, R., Luke, C.A., and Shelby, M.D. Comparative cytogenetic analysis of bone marrow damage induced in male B6C3F1 mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen Vol. 9 (1987) 235-250
- Mice
Organ Systems Toxicity
- 5 CONSECUTIVE DAYS Dominant Lethal (Inhalation)
(T0183A) Completed
- Citation: PNL-6545
- M Mice: Swiss
- Dose: 200, 1000, 5000 PPM
- GD 6-15 Conventional Teratology (Inhalation)
(TER85144) Completed
- Citation: PNL-6412
- F Mice: Swiss
- Mice Maternal Positive
- Mice Fetal Positive
- Dose: 0, 40, 200, 1000 PPM
- GS 6-19 Conventional Teratology (Inhalation)
(TER89041) Completed
- Citation: DE88004186/XAB
- F Rats: Sprague Dawley
- Rats Maternal Negative
- Rats Fetal Negative
- Dose: 0, 40, 200, 1000 PPM
Web page last updated on January 22, 2009