Testing Status of Agents at NTP
Chlorothalonil
CASRN: 1897-45-6
Formula: C8-CL4-N2
Synonyms/Common Names:
- 2,4,5,6-TETRACHLORO-1,3-BENZENEDICARBONITRILE (9CI)
Known Uses:
FUNGICIDE, BACTERICIDE, NEMATOCIDE
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C00102) Completed
- NTIS No. PB286369
(Peer Review 06/29/1978)
Citation: Bioassay of Chlorothalonil for Possible Carcinogenicity (CAS No. 1897-45-6) - Rats: Osborne Mendel; Mice: B6C3F1
- NTIS No. PB286369
(Peer Review 06/29/1978)
- 13-Week (Dosed-Feed)
(C00102) Completed
- NTIS No. PB286369
(Peer Review 06/29/1978)
Citation: Bioassay of Chlorothalonil for Possible Carcinogenicity (CAS No. 1897-45-6) - Rats: Osborne Mendel; Mice: B6C3F1
- Dose: R: 0,1250,20000, M: 0,1250,40000 PPM/5 PER GROUP
- NTIS No. PB286369
(Peer Review 06/29/1978)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C00102) Report Complete
- TR-041 (NTIS No. PB286369)
(Peer Review 06/29/1978)
Bioassay of Chlorothalonil for Possible Carcinogenicity (CAS No. 1897-45-6) - Rats: Osborne Mendel; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0,5063,10126 (AVG), FM: 0,3000,6000 (AVG), MM: 0,2688,5375 (AVG) PPM/50 PER GROUP
- TR-041 (NTIS No. PB286369)
(Peer Review 06/29/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(739007) Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Drosophila
(315727) Completed
- Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Mouse Lymphoma
(351015) Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Positive
- Salmonella
(323726) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Web page last updated on January 22, 2009