National Toxicology Program

CASRN: 7681-49-4

Formula: F-Na

Known Uses:

INSECTICIDE, ENAMELS, GLASS MIXES, STEEL DE-GASSING AGENT, ELECTROPLATING FLUXES, FLUORIDATION OF DRINKING WATER, DISINFECTING FERMENTATION APPARATUS, PRESERVING WOOD, PASTES, MANUF. COATED PAPER, DENTAL CARIES PROPHYLACTIC (MERCK 1989)

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Water)  (C55221B) Report Complete 
  • TR-393 (NTIS No. PB91-178137)  (Peer Review 04/26/1990)
    Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4)in F344/N Rats and B6C3F1 Mice (Drinking WaterStudies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R&M: 0,25,100,175 PPM
• 2-YEAR (Dosed-Water)  (C55221D) Completed 
  • Citation: Supplemental 2-Year Sodium Fluoride Male Rat Study (available on NTP website http://ntp.niehs.nih.gov/go/16389)
  • Rats: F344/N
  • Dose: MALE RATS: 0, 250 PPM

Genetic Toxicology

• Chromosome Aberrations  (A12928) Completed 
  • Mice
  • Chromosome Aberation  Negative (Nonstandard Protocol) 
• In Vitro Cytogenetics (CA/SCE)  (510381) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Negative 
• In Vitro Cytogenetics (CA/SCE)  (665475) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (855441) Completed 
  • Citation: Caspary, W., Myhr, B., Bowers, L., McGregor, D., Riach, C., and Brown, A. Mutagenic activity of fluorides in mouse lymphoma cells. Mutation Res. Vol. 187 (1987) 165-180
  •  Positive 
• Mouse Lymphoma  (932658) Completed 
  •  Positive 
• Micronucleus  (A12928) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (687373) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 

Organ Systems Toxicity

• Conventional Teratology (Dosed-Water)  (TER91022) Completed 
  • NTIS No. PB95-109997
    Citation: Final Report on the Developmental Toxicity of Sodium Flouride in Sprague-Dawley (CD) Rats
  • NTIS No. PB95-110193
    Citation: Final Report on the Developmental Toxicity of Sodium Flouride in Sprague-Dawley (CD) Rats
  • Rats: Sprague Dawley
  • Rats Maternal ? 
  • Rats Fetal Negative 
  • Dose: 0, 50, 150, 300 PPM
• Conventional Teratology (Dosed-Water)  (TER91033) Completed 
  • NTIS No. PB94-142684
    Citation: Final Report on the Developmental Toxicity of Sodium Flouride in New Zealand White Rabbits
  • NTIS No. PB94-142809
    Citation: Final Report on the Developmental Toxicity of Sodium Flouride in New Zealand White Rabbits
  • Rabbit: New Zealand White
  • Rabbits Maternal Positive 
  • Rabbits Fetal Positive 
  • Dose: 0, 100, 200, 400 PPM
• Conventional Teratology (Dosed-Water)  (TER91131) Completed 
  • Rabbit: New Zealand White
  • Rabbits Maternal Positive 
  • Rabbits Fetal Positive 
  • Dose: I: 0, 50, 300, 500 PPM OR II: 0, 50, 150, 300 PPM