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Sponsored by: |
Sichuan University |
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Information provided by: | Sichuan University |
ClinicalTrials.gov Identifier: | NCT00798018 |
It has been proven that tracheal tube inflated with lidocaine could decrease the post-intubation sore throat in nitrous oxide anesthesia. In the investigators study, the investigators would like to evaluate the effect of lidocaine inflation in non-nitrous oxide anesthesia and compare the effect of tetracaine, the best mucosal local anesthetics with lidocaine.
Condition | Intervention |
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Pharyngitis |
Drug: lidocaine and tetracaine |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Double Blind (Subject, Outcomes Assessor), Parallel Assignment |
Official Title: | Effect of Intra-Cuff Lidocaine and Tetracaine on Tracheal Tube-Induced Emergence Phenomena |
Estimated Enrollment: | 100 |
Study Start Date: | October 2008 |
Estimated Primary Completion Date: | February 2009 (Final data collection date for primary outcome measure) |
The patients were divided into air, saline and 2% lidocaine and 1% tetracaine groups of 25 each using sealed envelope technique. The cuff of the endotracheal tube was inflated by the inflation medium (with the help of intracuff pressure monitoring device) to occlude the leak around the tube by the Minimal Occlusive Volume Technique. This was done by the same anaesthesiologist in all the patients. The cuff volume and pressure were then recorded. The primary outcome of the study was to evaluate the post-intubation sore throat using the visual analogue scale 6h, 24h and 48h after extubation. The secondary outcomes were incidence of complications during emergence of anesthesia and after xtubation. Intra-cuff pressure monitoring was done with a pressure monitor, which consisted of the pressure gauge, three-way stopcock whose one end was attached to the pressure monitoring line. Net volume of the inflation medium was noted. Volume of the inflation medium, intra cuff pressure, duration from intubation to extubation and volume of the inflation medium withdrawn from the cuff was noted. Incidence (Yes/No) of tube intolerance, coughing on tube, restlessness, hoarseness, sore throat, breathlessness and laryngospasm were analyzed by the anaesthesiologist who did not know which group the patient belonged to.
Ages Eligible for Study: | 18 Years to 60 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Han Huang, M.D | +86-0-13880259785 | huanghan1981@hotmail.com |
China, Sichuan | |
Department of Anesthesiology, West China Second Hospital, Sichuan University | Recruiting |
Chengdu, Sichuan, China, 610041 | |
Contact: Wei Huang, M.D +86-28-85503752 | |
Principal Investigator: Han Huang, M.D |
Principal Investigator: | Han Huang, M.D | Department of Aensthesiology, West China 2nd Hospital, Sichuan University |
Responsible Party: | Department of Anesthesiology, West China Second Hospital ( Dr. ) |
Study ID Numbers: | ICLT |
Study First Received: | November 24, 2008 |
Last Updated: | November 24, 2008 |
ClinicalTrials.gov Identifier: | NCT00798018 |
Health Authority: | China: Ethics Committee |
lidocaine tetracaine tracheal intubation pharyngitis |
Tetracaine Otorhinolaryngologic Diseases Respiratory Tract Diseases Respiratory Tract Infections |
Lidocaine Stomatognathic Diseases Pharyngitis Pharyngeal Diseases |
Sensory System Agents Therapeutic Uses Physiological Effects of Drugs Central Nervous System Depressants Anesthetics Cardiovascular Agents |
Anti-Arrhythmia Agents Peripheral Nervous System Agents Central Nervous System Agents Pharmacologic Actions Anesthetics, Local |