National Toxicology Program

CASRN: 110-00-9

Formula: C4-H4-O

Synonyms/Common Names:

• OXACYCLOPENTADIENE

Known Uses:

CHEMICAL INTERMEDIATE. SOLVENT FOR RESINS. IN LACQUER FORMATION. ORGANIC SYNTHESIS. (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C56202) Completed 
  • NTIS No. PB93-228419  (Peer Review 03/11/1991)
    Citation: Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F1 Mice(Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C56202) Completed 
  • NTIS No. PB93-228419  (Peer Review 03/11/1991)
    Citation: Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F1 Mice(Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R & FM: 0,4,60, MM: 0,2,30 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C56202) Report Complete 
  • TR-402 (NTIS No. PB93-228419)  (Peer Review 03/11/1991)
    Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F1 Mice(Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: R: 0,2,4,8, M: 0,8,15 MG/KG/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination  (S0756) Completed 
  • Citation: BURKA, L.T., WASHBURN, K.D., AND IRWIN R.D., DISPOSITION OF [14C]FURAN IN THE MALE F344 RAT JRNL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 34:245-257, 1991
  • M Rats: F344/N

Genetic Toxicology

• Chromosome Aberrations  (635376) Completed 
  • Mice
  • Chromosome Aberation  Positive 
• In Vitro Cytogenetics (CA/SCE)  (950997) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (591334) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (048853) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Salmonella  (717172) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 
• Salmonella  (734219) Completed 
  •  Weakly Positive 
• Sister Chromatid Exchanges  (635376) Completed 
  • Mice
  • Sister Chromatid  Negative