Testing Status of Agents at NTP
Sodium nitrite
CASRN: 7632-00-0
Formula: NA N O2
Synonyms/Common Names:
- DIAZOTIZING SALTS
- NITROUS ACID, SODIUM SALT
Known Uses:
CHEM. INTERM., PRESERVATIVE IN FOOD, MANUF. AZO DYES, VASODILATOR, ANTIDOTE FOR CYANIDE POISONING (MERCK 1989)
Short-Term Toxicity
- 13-WEEK (Dosed-Water)
(C88007) Completed
- NTIS No. PB2001-107676
Citation: Toxicology and Carcinogenesis Studies of Sodium Nitrite (CAS No. 7632-00-0) IN F344/N Rats and B6C3F1 Mice (Drinking Water Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 375 - 5000 PPM/10 PER GROUP
- NTIS No. PB2001-107676
Long-Term Carcinogenicity
- 2-YEAR (Dosed-Water)
(C88007B) Report Complete
- TR-495 (NTIS No. PB2001-107676)
(Peer Review 05/18/2000)
Toxicology and Carcinogenesis Studies of Sodium Nitrite (CAS No. 7632-00-0) IN F344/N Rats and B6C3F1 Mice (Drinking Water Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice Equivocal Evidence
- Dose: R&M: 0, 0.075, 0.15, OR 0.3%; 50/SEX/DOSE
- TR-495 (NTIS No. PB2001-107676)
(Peer Review 05/18/2000)
Special Studies
- Toxicokinetic Study (Gavage; Intravenous)
(S0548) Completed
- Citation: TOXICOKINETICS OF SODIUM NITRITE IN RODENTS. AMENDED REPORT. 03/10/04. [AMENDED FINAL REPORT CHEM00474. 03/10/04. AMENDED REPORTS OF CHEM00475 (PART 3) AND CHEM00474 (PART 2) ARE INCLUDED IN THIS REPORT].
- M/F Rats: F344/N; M/F Mice: B6C3F1; M/F Rats: F344/N; M/F Mice: B6C3F1
- Dose: RATS (M & F) IV=20MG/KG, ORALLY=40 OR 80MG/KG MICE (M & F) IV=20MG/KG, ORALLY=62.5 OR 125MG/KG
Genetic Toxicology
- Micronucleus
(A10342) Completed
- Rats: F344
- Male Negative
- Micronucleus
(A17282) Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Micronucleus
(A52858) Completed
- Mice: B6C3F1
- Male Negative
- Salmonella
(359703) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Positive
Organ Systems Toxicity
- Continuous Breeding (Dosed-Water)
(RACB88071) Completed
- NTIS No. PB91-132027
Citation: Final Report on the Reproductive Toxicity of Sodium Nitrite in Swiss CD-1 Mice - M/F Mice: Swiss
- Dose: 0,.06,.12,.24,.36,.48%; 0,.06,.12,.24%; N/A; 0,.24%
- NTIS No. PB91-132027
Web page last updated on January 22, 2009