National Toxicology Program

CASRN: 67-72-1

Related: HALOGENATED ETHANES CS (HAXACHLOROETHANE)

Formula: C2-CL6

Synonyms/Common Names:

• CARBON HEXACHLORIDE

Known Uses:

SOLVENT, IN EXPLOSIVES, CAMPHOR SUBSTITUTE IN CELLULOID, IN PRODUCTION OF METALS, ANTIHELMINTIC DRUG, MOTH REPELLANT, RUBBER VULCANIZING, FLAME PROOFING (HSDB 1990)

Short-Term Toxicity

• 14-Day (Gavage)  (C04604A) Completed 
  • NTIS No. PB282668  (Peer Review 01/18/1978)
    Citation: Bioassay of Hexachloroethane for Possible Carcinogenicity (CAS No. 67-72-1)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 14-Day (Gavage)  (C04604B) Completed 
  • NTIS No. PB90-170895  (Peer Review 10/03/1988)
    Citation: Toxicology and Carcinogenesis Studies of Hexachloroethane (CAS No. 67-72-1) in F344/N Rats (Gavage Studies)
  • Rats: F344/N
• 13-Week (Gavage)  (C04604A) Completed 
  • NTIS No. PB282668  (Peer Review 01/18/1978)
    Citation: Bioassay of Hexachloroethane for Possible Carcinogenicity (CAS No. 67-72-1)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,178,1780, M: 0,316,3160 MG/KG/5 PER GROUP
• 13-Week (Gavage)  (C04604B) Completed 
  • NTIS No. PB90-170895  (Peer Review 10/03/1988)
    Citation: Toxicology and Carcinogenesis Studies of Hexachloroethane (CAS No. 67-72-1) in F344/N Rats (Gavage Studies)
  • Rats: F344/N
  • Dose: 0,.047,.750 G/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C04604A) Report Complete 
  • TR-068 (NTIS No. PB282668)  (Peer Review 01/18/1978)
    Bioassay of Hexachloroethane for Possible Carcinogenicity (CAS No. 67-72-1)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R: 0,212,423 M:0,590,1179 MG/KG/50 PER GROUP
• 2-YEAR (Gavage)  (C04604B) Report Complete 
  • TR-361 (NTIS No. PB90-170895)  (Peer Review 10/03/1988)
    Toxicology and Carcinogenesis Studies of Hexachloroethane (CAS No. 67-72-1) in F344/N Rats (Gavage Studies)
  • Rats: F344/N
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats No Evidence 
  • Dose: MR: 0, 10, 20, FR: 0, 80, 160 MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (415312) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Salmonella  (188925) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative 
• Salmonella  (248997) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative