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Our Science – Anderson Website

Lucy M. Anderson, Ph.D., D.A.B.T.

Selected Publications
1)  Diwan B, Sipowicz M, Logsdon D, Gorelick P, Anver M, Kasprzak K, Anderson L.
Marked liver tumorigenesis by Helicobacter hepaticus requires perinatal exposure.
Environmental Health Perspectives. 2008. In Press. [Journal]
2)  Anderson LM.
Environmental genotoxicants/carcinogens and childhood cancer: filling knowledge gaps.
Curr Probl Pediatr Adolesc Health Care. 38: 50-63, 2008. [Journal]
3)  Sithanandam G, Anderson LM.
The ERBB3 receptor in cancer and cancer gene therapy.
Cancer Gene Ther. 15: 413-448, 2008. [Journal]
4)  Romanowska M, Maciag A, Smith AL, Fields JR, Fornwald LW, Kikawa KD, Kasprzak KS, Anderson LM.
DNA damage, superoxide, and mutant K-ras in human lung adenocarcinoma cells.
Free Radic. Biol. Med. 43: 1145-55, 2007. [Journal]
5)  Schmidt AL, Anderson LM.
Repetitive DNA elements as mediators of genomic change in response to environmental cues.
Biol Rev Camb Philos Soc. 1-13, 2006. [Journal]
6)  Anderson LM.
Environmental genotoxicants/carcinogens and childhood cancer: Bridgeable gaps in scientific knowledge.
Mutat. Res. 608: 136-56, 2006. [Journal]
7)  Calvert RJ, Tepper S, Kammouni W, Anderson LM, Kritchevsky D.
Elevated K-ras activity with cholestyramine and lovastatin, but not konjac mannan or niacin in lung--importance of mouse strain.
Biochem. Pharmacol. 72: 1749-55, 2006. [Journal]
8)  Romanowska M, Kikawa KD, Fields JR, Maciag A, North SL, Shiao YH, Kasprzak KS, Anderson LM.
Effects of selenium supplementation on expression of glutathione peroxidase isoforms in cultured human lung adenocarcinoma cell lines.
Lung Cancer. 55: 35-42, 2007. [Journal]
9)  Anderson LM, Riffle L, Wilson R, Travlos GS, Lubomirski MS, Alvord WG.
Preconceptional fasting of fathers alters serum glucose in offspring of mice.
Nutrition (Burbank, Los Angeles County, Calif.). 22: 327-31, 2006. [Journal]
10)  Sithanandam G, Smith GT, Fields JR, Fornwald LW, Anderson LM.
Alternate paths from epidermal growth factor receptor to Akt in malignant versus nontransformed lung epithelial cells: ErbB3 versus Gab1.
Am. J. Respir. Cell Mol. Biol. 33: 490-9, 2005. [Journal]
11)  Anderson LM.
Cancer biology and hormesis: comments on Calabrese (2005).
Crit Rev Toxicol. 35: 583-6, 2005. [Journal]
12)  Shiao YH, Crawford EB, Anderson LM, Patel P, Ko K.
Allele-specific germ cell epimutation in the spacer promoter of the 45S ribosomal RNA gene after Cr(III) exposure.
Toxicol Appl Pharmacol. 205: 290-6, 2005. [Journal]
13)  Sithanandam G, Fornwald LW, Fields J, Anderson LM.
Inactivation of ErbB3 by siRNA promotes apoptosis and attenuates growth and invasiveness of human lung adenocarcinoma cell line A549.
Oncogene. 24: 1847-59, 2005. [Journal]
14)  Dennis PA, Van Waes C, Gutkind JS, Kellar KJ, Vinson C, Mukhin AG, Spitz MR, Bailey-Wilson JE, Yeh GC, Anderson LM, Wiest JS.
The biology of tobacco and nicotine: bench to bedside.
Cancer Epidemiol Biomarkers Prev. 14: 764-7, 2005. [Journal]
15)  Vucenik I, Ramakrishna G, Tantivejkul K, Anderson LM, Ramljak D.
Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation.
Breast Cancer Res Treat. 91: 35-45, 2005. [Journal]
16)  Maciag A, Anderson LM.
Reactive oxygen species and lung tumorigenesis by mutant K-ras: a working hypothesis.
Exp Lung Res. 31: 83-104, 2005. [Journal]
17)  Maciag A, Sithanandam G, Anderson LM.
Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells.
Carcinogenesis. 25: 2231-7, 2004. [Journal]
18)  Anderson LM.
Introduction and overview. Perinatal carcinogenesis: growing a node for epidemiology, risk management, and animal studies.
Toxicol Appl Pharmacol. 199: 85-90, 2004. [Journal]
19)  Cheng RY, Hockman T, Crawford E, Anderson LM, Shiao YH.
Epigenetic and gene expression changes related to transgenerational carcinogenesis.
Mol Carcinog. 40: 1-11, 2004. [Journal]
20)  Anderson LM.
Predictive values of traditional animal bioassay studies for human perinatal carcinogenesis risk determination.
Toxicol Appl Pharmacol. 199: 162-74, 2004. [Journal]
21)  Souliotis VL, Sfikakis PP, Anderson LM, Kyrtopoulos SA.
Intra- and intercellular variations in the repair efficiency of O6-methylguanine, and their contribution to kinetic complexity.
Mutat Res. 568: 155-70, 2004. [Journal]
22)  Cheng RY, Birely LA, Lum NL, Perella CM, Cherry JM, Bhat NK, Kasprzak KS, Powell DA, Alvord WG, Anderson LM.
Expressions of hepatic genes, especially IGF-binding protein-1, correlating with serum corticosterone in microarray analysis.
J Mol Endocrinol. 32: 257-78, 2004. [Journal]
23)  Maciag A, Anderson LM.
Reactive oxygen species and lung tumorigenesis by mutant K-ras: a working hypothesis.
Exp Lung Res. 31: 83-104, 2005. [Journal]
24)  Sithanandam G, Smith GT, Masuda A, Takahashi T, Anderson LM, Fornwald LW.
Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathway.
Carcinogenesis. 24: 1581-92, 2003. [Journal]
25)  Anderson LM.
Predictive values of traditional animal bioassay studies for human perinatal carcinogenesis risk determination.
Toxicol Appl Pharmacol. 199: 162-74, 2004. [Journal]
26)  Cisneros FJ, Wilson R, Travlos G, Anderson LM, Branch S.
Susceptibility to postnatal growth retardation induced by 5-AZA-2'-deoxycytidine in utero: gender specificity and correlation with reduced insulin-like growth factor 1.
Life Sci. 72: 2887-94, 2003. [Journal]
27)  Calvert RJ, Tepper S, Diwan BA, Anderson LM, Kritchevsky D.
Treatment with lovastatin, cholestyramine or niacin alters K-ras membrane association in mouse lung in a strain-dependent manner: results in females.
Biochem Pharmacol. 66: 393-403, 2003. [Journal]
28)  Cheng RY, Zhao A, Alvord WG, Powell DA, Bare RM, Masuda A, Takahashi T, Anderson LM, Kasprzak KS.
Gene expression dose-response changes in microarrays after exposure of human peripheral lung epithelial cells to nickel(II).
Toxicol Appl Pharmacol. 191: 22-39, 2003. [Journal]
29)  Cheng RY, Alvord WG, Powell D, Kasprzak KS, Anderson LM.
Increased serum corticosterone and glucose in offspring of chromium(III)-treated male mice.
Environ Health Perspect. 110: 801-4, 2002. [Journal]
30)  Kammouni W, Ramakrishna G, Sithanandam G, Smith GT, Fornwald LW, Masuda A, Takahashi T, Anderson LM.
Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence.
Cell Growth Differ. 13: 441-8, 2002. [Journal]
31)  Cheng RY, Alvord WG, Powell D, Kasprzak KS, Anderson LM.
Microarray analysis of altered gene expression in the TM4 Sertoli-like cell line exposed to chromium(III) chloride.
Reprod Toxicol. 16: 223-36, 2002. [Journal]
32)  Ramakrishna G, Perella C, Birely L, Diwan BA, Fornwald LW, Anderson LM.
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicol Appl Pharmacol. 179: 21-34, 2002. [Journal]
33)  Maciag A, Bialkowska A, Espiritu I, Powell D, Alvord WG, Kasprzak KS, Anderson LM, Witschi HR.
Sidestream smoke: gestation-stage specific oxidative DNA damage in fetuses and mothers.
Archiv Environ Health. 58: 238-244, 2003. [Journal]
34)  Shiao YH, Kamata SI, Li LM, Hooth MJ, DeAngelo AB, Anderson LM, Wolf DC.
Mutations in the VHL gene from potassium bromate-induced rat clear cell renal tumors.
Cancer Lett. 187: 207-14, 2002. [Journal]
35)  Powell DA, Anderson LM, Cheng RY, Alvord WG.
Robustness of the Chen-Dougherty-Bittner procedure against non-normality and heterogeneity in the coefficient of variation.
J Biomed Opt. 7: 650-60, 2002. [Journal]
36)  Calvert RJ, Ramakrishna G, Tepper S, Diwan BA, Anderson LM, Kritchevsky D.
Alterations in membrane-bound and cytoplasmic K-ras protein levels in mouse lung induced by treatment with lovastatin, cholestyramine, or niacin: effects are highly mouse strain dependent.
Biochem Pharmacol. 64: 41-8, 2002. [Journal]
37)  Souliotis VL, Henneman JR, Reed CD, Chhabra SK, Diwan BA, Anderson LM, Kyrtopoulos SA.
DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesis.
Mutat Res. 500: 75-87, 2002. [Journal]
38)  Shiao YH, Ramakrishna G, Anderson LM, Perantoni AO, Rice JM, Diwan BA.
Down-regulation of von Hippel-Lindau protein in N-nitroso compound-induced rat non-clear cell renal tumors.
Cancer Lett. 179: 33-8, 2002. [Journal]
39)  Khan QA, Dipple A, Anderson LM.
Protease inhibitor-induced stabilization of p21waf1/cip1 and cell-cycle arrest in chemical carcinogen-exposed mammary and lung cells.
Mol Carcinog. 33: 1-8, 2002. [Journal]
40)  Singh R, Leuratti C, Josyula S, Sipowicz MA, Diwan BA, Kasprzak KS, Schut HA, Marnett LJ, Anderson LM, Shuker DE.
Lobe-specific increases in malondialdehyde DNA adduct formation in the livers of mice following infection with Helicobacter hepaticus.
Carcinogenesis. 22: 1281-7, 2001. [Journal]
41)  McKenna IM, Ramakrishna G, Diwan BA, Kang Y, Shiao YH, Wakefield LM, Powell DA, Anderson LM, Jakowlew SB.
Heterozygous inactivation of TGF-beta1 increases the susceptibility to chemically induced mouse lung tumorigenesis independently of mutational activation of K-ras.
Toxicol Lett. 123: 151-8, 2001. [Journal]
42)  Lynch MA, Petrel TA, Song H, Knobloch TJ, Casto BC, Ramljak D, Anderson LM, DeGroff V, Stoner GD, Brueggemeier RW, Weghorst CM.
Responsiveness to transforming growth factor-beta (TGF-beta)-mediated growth inhibition is a function of membrane-bound TGF-beta type II receptor in human breast cancer cells.
Gene Expr. 9: 157-71, 2001. [Journal]
43)  Ortega R, Deves G, Bonnin-Mosbah M, Salome M, Susini J, Anderson LM, Kasprzak KS.
Chromium mapping in male mice reproductive glands exposed to CrCl3 using proton and X-ray synchrotron radiation microbeams.
Nucl Instr Meth. Vol. B 181: 485-8, 2001. [Journal]
44)  McKenna IM, Ramakrishna G, Diwan BA, Shiao YH, Kasprzak KS, Powell DA, Anderson LM.
K-ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas.
Mutat Res. 490: 57-65, 2001. [Journal]
45)  Khan QA, Anderson LM.
Hydrocarbon carcinogens evade cellular defense mechanism of G1 arrest in nontransformed and malignant lung cell lines.
Toxicol Appl Pharmacol. 173: 105-113, 2001. [Journal]
46)  Ramakrishna G, Sithanandam G, Cheng RY, Fornwald LW, Smith GT, Diwan BA, Anderson LM.
K-ras p21 expression and activity in lung and lung tumors.
Exp Lung Res. 26: 659-671, 2000. [Journal]
47)  Anderson LM, Diwan BA, Fear NT, Roman E.
Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal models.
Environ Health Perspect. 108 Suppl 3: 573-594, 2000. [Journal]
48)  Sipowicz MA, Anderson LM, Kasprzak KS.
Oxidative DNA damage in liver of mice with different susceptibility to hepatocarcinogenesis.
Rocz Akad Med Bialymst. 45: 116-21, 2000. [Journal]
49)  Chhabra SK, Anderson LM, Perella C, Desai D, Amin S, Kyrtopoulos SA, Souliotis VL.
Coexposure to ethanol with N-nitrosodimethylamine or 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone during lactation of rats: marked increase in O(6)-methylguanine-DNA adducts in maternal mammary gland and in suckling lung and kidney.
Toxicol Appl Pharmacol. 169: 191-200, 2000. [Journal]
50)  Josyula S, Schut HA, Diwan BA, Anver MR, Anderson LM.
Age-related alterations in 32P-postlabeled DNA adducts in livers of mice infected with the tumorigenic bacterial pathogen, Helicobacter hepaticus.
Int J Oncol. 17: 811-8, 2000. [Journal]
51)  Ramakrishna G, Bialkowska A, Perella C, Birely L, Fornwald LW, Diwan BA, Shiao YH, Anderson LM.
Ki-ras and the characteristics of mouse lung tumors.
Mol Carcinog. 28: 156-67, 2000. [Journal]
52)  Olshan AF, Anderson L, Roman E, Fear N, Wolff M, Whyatt R, Vu V, Diwan BA, Potischman N.
Workshop to identify critical windows of exposure for children's health: cancer work group summary.
Environ Health Perspect. 108 Suppl 3: 595-7, 2000. [Journal]
53)  Josyula S, Lu LJ, Salazar JJ, Nerurkar PV, Jones AB, Grady JJ, Snyderwine EG, Anderson LM.
DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in fetal tissues of patas monkeys after transplacental exposure.
Toxicol Appl Pharmacol. 166: 151-60, 2000. [Journal]
54)  Bench G, Grant P, Anderson LM, Kasprzak KS.
Micro-pixe analysis of the testes and sperm of CrCl3-treated mice. In Cenleno JA, Collery PH, Vernet G, Finkelman RB, Gibb H, and Etienne JC (Eds).
Metals Ions in Biology and Medicine. John Libbey Eurotext, Paris: 339-41, 2000. [Journal]
55)  Bialkowska A, Bialkowski K, Gerschenson M, Diwan BA, Jones AB, Olivero OA, Poirier MC, Anderson LM, Kasprzak KS, Sipowicz MA.
Oxidative DNA damage in fetal tissues after transplacental exposure to 3'-azido-3'-deoxythymidine (AZT).
Carcinogenesis. 21: 1059-62, 2000. [Journal]
56)  Ramljak D, Calvert RJ, Wiesenfeld PW, Diwan BA, Catipovic B, Marasas WF, Victor TC, Anderson LM, Gelderblom WC.
A potential mechanism for fumonisin B1-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity.
Carcinogenesis. 21: 1537-46, 2000. [Journal]
57)  Shiao YH, Resau JH, Nagashima K, Anderson LM, Ramakrishna G.
The von Hippel-Lindau tumor suppressor targets to mitochondria.
Cancer Res. 60: 2816-9, 2000. [Journal]
58)  Hecht SS, Trushin N, Chhabra SK, Anderson LM, Nerurkar PV.
Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured monkey lung explants.
Drug Metab Dispos. 28: 5-9, 2000. [Journal]
59)  Diwan BA, Ramakrishna G, Anderson LM, Ramljak D.
Overexpression of Grb2 in inflammatory lesions and preneoplastic foci and tumors induced by N-nitrosodimethylamine in Helicobacter hepaticus-infected and -noninfected A/J mice.
Toxicol Pathol. 28: 548-54, 2000. [Journal]

This page was last updated on 9/18/2008.