Testing Status of Agents at NTP
Lindane
CASRN: 58-89-9
Formula: C6-H6-CL6
Synonyms/Common Names:
- GAMA-HCH
- (1ALPHA,2ALPHA,3BETA,4ALPHA,5ALPHA,6BETA)-1,2,3,4,5,6-HEXACHLORO-CYCLOHEXANE (9CI)
Known Uses:
INSECTICIDE, PEDICULICIDE, SCABICIDE (MERCK 1989)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C00204) Completed
- NTIS No. PB273480
(Peer Review 07/25/1977)
Citation: Bioassay of Lindane for Possible Carcinogenicity (CAS No. 58-89-9) - Rats: Osborne Mendel; Mice: B6C3F1
- NTIS No. PB273480
(Peer Review 07/25/1977)
- 13-Week (Dosed-Feed)
(C00204) Completed
- NTIS No. PB273480
(Peer Review 07/25/1977)
Citation: Bioassay of Lindane for Possible Carcinogenicity (CAS No. 58-89-9) - Rats: Osborne Mendel; Mice: B6C3F1
- Dose: R: 0,160,2560, M: 0,40,1280 PPM/5 PER GROUP
- NTIS No. PB273480
(Peer Review 07/25/1977)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C00204) Report Complete
- TR-014 (NTIS No. PB273480)
(Peer Review 07/25/1977)
Bioassay of Lindane for Possible Carcinogenicity (CAS No. 58-89-9) - Rats: Osborne Mendel; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: MR: 0,236,472 (AVG), FR: 0,135,270 (AVG), M: 0,80,160 PPM/50 PER GROUP
- TR-014 (NTIS No. PB273480)
(Peer Review 07/25/1977)
Special Studies
- C. elegans
(S0929) Completed
- Nematode: C. elegans
- Dose: feed (0,.025,.032,.04,.05,.063,.079,.1,.13,.16,.20,.25) mM 11/02/06 repro (0,.01,.016,.025,.04,.063,.1,.16,.25,.4,.63,1) mM 02/23/06 GROWTH: (0,.01,.016,.025,.04,.063,.1,.16,.25,.4,.63,1) mM 06/27/07
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(931320) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Negative
- Mouse Lymphoma
(849017) Completed
- Inconclusive
- Salmonella
(946710) Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Negative
Web page last updated on January 22, 2009