National Toxicology Program

CASRN: 2058-46-0

Formula: C22-H24-N2-O9.CL-H

Synonyms/Common Names:

• (4S-(4-A,4A-A,5-A,5A-A,6-B,12A-A))-4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,5,6,10,12,12-A-HEAHYDROXY-6-METHYL-1,11-DIOXO-2-NAPHTHACENECARBOXAMIDE HCL

Known Uses:

ANTIBIOTIC, ANTIMICROBIAL, ANIMAL FEED ADDITIVE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C56473) Completed 
  • NTIS No. PB87-204103  (Peer Review 12/09/1985)
    Citation: Toxicology and Carcinogenesis Studies of Oxytetracycline Hydrochloride (CAS No. 2058-46-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C56473) Completed 
  • NTIS No. PB87-204103  (Peer Review 12/09/1985)
    Citation: Toxicology and Carcinogenesis Studies of Oxytetracycline Hydrochloride (CAS No. 2058-46-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,3100,50000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C56473) Report Complete 
  • TR-315 (NTIS No. PB87-204103)  (Peer Review 12/09/1985)
    Toxicology and Carcinogenesis Studies of Oxytetracycline Hydrochloride (CAS No. 2058-46-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0,25000,50000 M: 0,6300,12500 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (604406) Completed 
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Not Tested 
  • Sister Chromatid Exchange Negative 
• In Vitro Cytogenetics (CA/SCE)  (682810) Completed 
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Not Tested 
• Drosophila  (377666) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (739218) Completed 
  • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
  • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
  •  Positive 
• Salmonella  (463949) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative 

Organ Systems Toxicity

• GD 6-15 Conventional Teratology (Gavage)  (TER82094) Completed 
  • NTIS No. PB83-182469
    Citation: Teratologic Evaluation of Oxytetracycline Hydrochloride in CD Rats
  • F Rats: Sprague Dawley
  • Rats Maternal Positive 
  • Rats Fetal Positive 
  • Dose: 1200, 1350, 1500 MG/KG/DAY
• GD 6-15 Conventional Teratology (Gavage)  (TER82095) Completed 
  • NTIS No. PB83-151027
    Citation: Teratologic Evaluation of Oxytetracycline Hydrochloride in CD-1 Mice
  • F Mice: Swiss
  • Mice Maternal Negative 
  • Mice Fetal Negative 
  • Dose: 1325, 1670, 2100 MG/KG/DAY