Summaries & Associations of Study Results
TR-429 Diethyl Phthalate
Target Organs and Levels of Evidence
NTP Technical Report Number 429
Produced from Chemtrack Database 09/19/01
CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
---|---|---|---|---|
DIETHYL PHTHALATE 84-66-2 |
11/17/93 | IN MANUFACTURE OF CELLULOID, COSMETICS, VARNISHES, AND DOPES. PLASTICIZER FOR CELLULOSE ESTER PLASTICS. INSECTICIDE SPRAYS. (TDB) | Topical R: 0,100,300 M: 0,7.5,15,30 UL/100 UL SOLUTION /50 PER GROUP | Hazleton Labs, Rockville, Gov't Services, Inc |
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
MR: NO EVIDENCE | ||||
OTHER :CONSIDERATIONS: | LIVER: FATTY DEGENERATION 26/50 8/50 4/51 | |||
NON-NEOPLASTIC LESIONS: | SKIN: ACANTHOSIS | |||
FR: NO EVIDENCE | ||||
OTHER :CONSIDERATIONS: | LIVER: FATTY DEGENERATION 23/50 11/50 3/50 | |||
MAMMARY GLAND: FIBROADENOMA 21/51 12/50 7/50 | ||||
NON-NEOPLASTIC LESIONS: | SKIN: ACANTHOSIS | |||
MM: EQUIVOCAL EVIDENCE | LIVER: ADENOMA 6/50 11/50 9/50 12/50 OR CARCINOMA 4/50 4/50 6/50 7/50 COMBINED 9/50 14/50 14/50 18/50 | |||
NON-NEOPLASTIC LESIONS: | LIVER: BASOPHILIC FOCI | |||
FM: EQUIVOCAL EVIDENCE | LIVER: ADENOMA 4/50 12/51 14/50 10/50 OR CARCINOMA 4/50 5/51 6/50 3/50 COMBINED 7/50 16/51 19/50 12/50 | |||
DIETHYL PHTHALATE/DIMETHYL PHTHALATE DIETH/DIMETH |
11/17/93 | DIETHYL: CELLULOID MANUFACTURE, COSMETICS, VARNISHES, DOPES, INSECTICIDAL SOAPS, PLASTICIZER. DIMETHYL: INSECTICIDES, PLASTICIZER, SOLVENT, DYE CARRIER, ROCKET FUEL | Topical 100 UL (PROMOTOR) NEAT CHEMICAL ON UNINITIATED AND DMBA INITIATED SKIN | Hazleton Labs, Rockville, Gov't Services, Inc |
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
NOTE: | 1-YEAR DERMAL INITIATION/PROMOTION STUDY IN MALE SWISS CD-1 MICE. THERE WAS NO EVIDENCE OF INITIATING OR PROMOTING ACTIVITY. MINOR DERMAL ACANTHOSIS WAS OBSERVED FOLLOWING 1 YEAR EXPOSURE TO DIETHYLPHTHALATE OR DIMETHYLPHTHALATE. |
Web page last updated on February 10, 2006