Application processes at NIH are changing. Applicant organizations are encouraged to start preparing for this transtion by registering with Grants.gov and NIH eRA Commons now. |
Mechanisms of Transmission and Dissemination of Transmissible Spongiform Encephalopathies (TSEs) (R21)
Release Date: March 3, 2006
Announcement Number: PA-06-193
Application Receipt Date:
June 1, 2006
October 1, 2006
February 16, 2007
June 16, 2007
October 16, 2007
February 16, 2008
June 16, 2008
Funding Contact: May Wong, Ph.D.
Program Area: Neural Environment
Brief Description:
The National Institute of Neurological Disorders and Stroke (NINDS) encourages investigator-initiated research grant applications
to study the mechanisms of transmission and dissemination of transmissible spongiform encephalopathies (TSEs). TSEs or “prion
diseases” are neurodegenerative disorders that can lead to dementia, motor dysfunction and eventually death. Iatrogenic transmission
of prion disease has been reported (transplantation of cadaveric cornea or dura mater, or injection of cadaveric human growth
hormone); however the best known mechanism of natural transmission of TSEs is via the gastrointestinal tract through ingestion
of contaminated food. Once in the digestive tract, prions are able to disseminate to the peripheral lymph organs and the Central
Nervous System (CNS). This PA is intended to expand research on how these diseases can spread within an affected population
and how infectious prions are then distributed through the body and ultimately to the CNS.
Choose an option to view additional funding announcements |
New Announcements | Research Area | RFAs Only | PAs Only | RFPs Only | Notices Only | Supplements Only | All Announcements | Archives |