National Toxicology Program

CASRN: 62-73-7

Formula: C4-H7-CL2-O4-P

Synonyms/Common Names:

• DDVP
• 2,2-DICHLOROETHENYL PHOSPHORIC ACID DIMETHYLESTER (9CI)

Known Uses:

INSECTICIDE. FUMIGANT. VETERINARY USE FOR QUICK KNOCKDOWN OF INSECTS. (TDB)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00113A) Completed 
  • NTIS No. PB270937  (Peer Review 09/00/1976)
    Citation: Bioassay of Dichlorvos for Possible Carcinogenicity (CAS No. 62-73-7)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00113A) Completed 
  • NTIS No. PB270937  (Peer Review 09/00/1976)
    Citation: Bioassay of Dichlorvos for Possible Carcinogenicity (CAS No. 62-73-7)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: 0,4000,12000 PPM/10 PER GROUP
• 13-Week (Gavage)  (C00113B) Completed 
  • NTIS No. PB90-198508  (Peer Review 07/14/1987)
    Citation: Toxicology and Carcinogenesis Studies of Dichlorvos (CAS No. 62-73-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,2,64, M: 0,5,160 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00113A) Report Complete 
  • TR-010 (NTIS No. PB270937)  (Peer Review 09/00/1976)
    Bioassay of Dichlorvos for Possible Carcinogenicity (CAS No. 62-73-7)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,150,650 (AVG), M: 0,650,1300 (AVG) PPM/50 PER GROUP
• 2-YEAR (Gavage)  (C00113B) Report Complete 
  • TR-342 (NTIS No. PB90-198508)  (Peer Review 07/14/1987)
    Toxicology and Carcinogenesis Studies of Dichlorvos (CAS No. 62-73-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Some Evidence 
  • Female Mice Clear Evidence 
  • Dose: R: 0,4,8, MM: 0,10,20, FM: 0,20,40 MG/KG/50 PER GROUP

Special Studies

• Cell Proliferation (Dosed-Feed)  (S0223) Completed 
  • Citation: CUNNINGHAM, ET. AL., RELATIONSHIP OF CARCINOGENICITY & CELLULAR PROLIFERATION INDUCED BY MUTAGENIC NONCARC VS CARC, FUND & APPL TOX 23, 363-369, 1994.
  • M Rats: F344/N
  • Dose: UP TO 400 PPM
• C. elegans  (S0901) Completed 
  • Nematode: C. elegans
  • Dose: feed (0,.01,.021,.046,.1,.21,.46,1,2.1,4.6,10,21) uM 5/17/07; growth (0,.1,.16..25,.4,.63,1,1.6,2.5,4,6.3,10) uM 6/19/06; repro (0,.1,.16,.25,.4,.63,1,1.6,2.5,4,6.3,10) uM 6/14/06

Genetic Toxicology

• Chromosome Aberrations  (755734) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• Chromosome Aberrations  (918411) Completed 
  • Mice
  • Chromosome Aberation  Negative (Nonstandard Protocol) 
• In Vitro Cytogenetics (CA/SCE)  (584062) Completed 
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (282595) Completed 
  • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
  •  Positive 
• Micronucleus  (A02017) Completed 
  • Rats: F344
  • Male Negative 
• Micronucleus  (A26112) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (632911) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive 
• Sister Chromatid Exchanges  (755734) Completed 
  • Mice
  • Sister Chromatid  Negative 
• Sister Chromatid Exchanges  (918411) Completed 
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol)