B cell depletion in Idiopathic Inflammatory Myopathy
Principal Investigator:
Jo Edwards, Shabina Sultan, David Isenberg, University College, London
Study Design:
Phase 1 open, at University College, London
Types & Number of IIM Studied:
Active Polymyositis or Dermatomyositis (N = 5)
Entry Criteria:
Definite Polymyositis or Dermatomyositis by Bohan and Peter criteria;
Refractory to standard therapy
IMACS Core Set Measures Included:
MITAX, Physician and Patient Global Activity Assessment, Manual Muscle
Testing (MMT-8), Health Assessment Questionnaire, muscle enzymes; Health
Related Quality of Life by SF-36
Other Measures Included:
Myometry, Activities of Daily Living, rash, B cells, serology
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