Testing Status of Agents at NTP
p,p'-Dichlorodiphenyl sulfone
CASRN: 80-07-9
Formula: C12-H8-CL2-02-S
Synonyms/Common Names:
- 1,1'-SULFONYLBIS(4-CHLORO-BENZENE) (9CI)
Known Uses:
STARTING MATERIAL IN PROD'N OF PLASTICS
Nomination Background
Short-Term Toxicity
- 13-WEEK (Dosed-Feed)
(C88120) Completed
- NTIS No. PB2002-100580
Citation: Toxicology and Carcinogenesis Studies ofp,p'-Dichlorodiphenyl Sulfone (CAS No. 80-07-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 30, 100, 300, 1000, & 3000 PPM; 10/GRP/SEX
- NTIS No. PB2002-100580
Long-Term Carcinogenicity
- 2-YEAR (Dosed-Feed)
(C88120B) Report Complete
- TR-501 (NTIS No. PB2002-100580)
(Peer Review 05/18/2000)
Toxicology and Carcinogenesis Studies ofp,p'-Dichlorodiphenyl Sulfone (CAS No. 80-07-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: MR: 0, 10, 30, OR 100 PPM; FR & MICE: 0, 30, 100, OR 300 PPM; 50/SEX/DOSE
- TR-501 (NTIS No. PB2002-100580)
(Peer Review 05/18/2000)
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage)
(S0160) Completed
- Citation: ABSORPTION AND DISPOSITION OF [14C]P,P'-DICHLORODIPHENYL SULFONE (DDS) ADMINISTERED TO F-344 RATS
- M Rats: F344/N
- Dose: 10, 100, 1000 MG/KG
- Absorption Disposition Metabolism Elimination
(S0595) Completed
- Citation: MATHEWS, J.M., BLACK, S.L., MATTHEWS, H.B.: P,P'-DICHLORODIPHENYL SULPHONE METABOLISM AND DISPOSITION IN RATS. DRUG MET. AND DISP., V24:NO.5:P579-587, 1996.
- M Rats: F344/N
- Dose: IV:10 mg/kg
- Toxicokinetic Study (Intravenous)
(S0631) Completed
- Citation: PRELIMINARY ONLY, NO FULL TKS DONE
- M Rats: F344/N
- Dose: 1.0 mg/kg
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(133717) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Inconclusive
- Micronucleus
(A64289) Completed
- Mice: B6C3F1
- Male Positive
- Salmonella
(147825) Completed
- Negative
Web page last updated on January 22, 2009