Testing Information

Testing Status of Agents at NTP

C.I. Pigment red 23

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http://ntp.niehs.nih.gov/go/TS-10210-D

CASRN: 6471-49-4

Formula: C24-H17-N5-O7

Synonyms/Common Names:

  • 3-HYDROXY-4-((2-METHOXY-5-NITROPHENYL)AZO)-N-(3-NITROPHENYL)-2-NAPTHALENECARBOXAMIDE (9CI)
  • RED 23, C.I. PIGMENT

Known Uses:

IN PAINT, INK, PLASTIC, RUBBER AND TEXTILE PRINTING. (TDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C60377) Completed 
    • NTIS No. PB93-228435  (Peer Review 03/11/1991)
      Citation: Toxicology and Carcinogenesis Studies of C.I. Pigment Red 23 (CAS No. 6471-49-4) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C60377) Completed 
    • NTIS No. PB93-228435  (Peer Review 03/11/1991)
      Citation: Toxicology and Carcinogenesis Studies of C.I. Pigment Red 23 (CAS No. 6471-49-4) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 3000, 6000, 12500, 25000, 50000 PPM (10 PER GROUP)

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C60377) Report Complete 
    • TR-411 (NTIS No. PB93-228435)  (Peer Review 03/11/1991)
      Toxicology and Carcinogenesis Studies of C.I. Pigment Red 23 (CAS No. 6471-49-4) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 10000, 25000, 50000 PPM (60 PER GROUP)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0031) Completed 
    • Citation: EL DAREER, S.M., TILLERY, K.F. & HILL, D.L.: INVESTIGATIONS ON THE DISPOSITION OF ORAL DOSES OF SOME WATER-INSOLUBLE PIGMENTS, BULL ENVIRON CONTAM TOXICOL, 32:171-174, 1984.
    • Rats
    • Dose: 5.2 MG/KG

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (115073) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Salmonella  (721735) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 

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Web page last updated on January 22, 2009