National Toxicology Program

CASRN: 106-88-7

Related: BUTYLENE OXIDE CAS 26249-20-7

Formula: C4-H8-O

Synonyms/Common Names:

• ETHYLOXIRANE

Known Uses:

FOR PROD'N OF BUTANEDIOLS, GLYCOL ESTERS & ETHERS, PREP'N OF SURFACTANTS & GASOLINE ADDITIVES, INTERMED. FOR POLYMERS, STABILIZER (HSDB 1990).

Short-Term Toxicity

• 14-Day (Inhalation)  (C55527) Completed 
  • NTIS No. PB88-216262  (Peer Review 08/19/1986)
    Citation: Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CAS No. 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Inhalation)  (C55527) Completed 
  • NTIS No. PB88-216262  (Peer Review 08/19/1986)
    Citation: Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CAS No. 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,50,800 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C55527) Report Complete 
  • TR-329 (NTIS No. PB88-216262)  (Peer Review 08/19/1986)
    Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CAS No. 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0,200,400, M: 0,50,100 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (333393) Completed 
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (855451) Completed 
  • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Positive 
• Mouse Lymphoma (NCI)  (G18246) Completed 
  • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
  • Mouse Lymphoma-NCI  Positive 
• Mouse Lymphoma (NCI)  (G71732) Completed 
  • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
  • Mouse Lymphoma-NCI  Positive 
• Mouse Lymphoma  (119097) Completed 
  • Citation: McGregor, D.B., Martin, R., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I. Results for nine compounds. Environ. Mutagen. Vol. 9 (1987) 143-160
  •  Positive 
• Micronucleus  (A16097) Completed 
  • Rats: F344
  • Male Negative 
• Salmonella (NCI)  (N-9093) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escerichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1985) 1-251
  • Salmonella-NCI  Negative 
• Salmonella  (970583) Completed 
  • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  •  Positive 

Organ Systems Toxicity

• 5 D/WK FOR 3 WEEKS BEFORE BREEDING, OR GD 1-19, OR 3 WEEKS BEFORE BREEDING PLUS GD 1-19. Conventional Teratology (Inhalation)  (T0056A) Completed 
  • NTIS No. PB81-168510
    Citation: Teratologic Assessment of Butylene Oxide, Styrene Oxide, Methylbromide
  • F Rats: Wistar
  • Dose: 250 OR 1000 PPM 7HR/D
• GD 1-24 Conventional Teratology (Inhalation)  (T0056B) Completed 
  • NTIS No. PB81-168510
    Citation: Teratologic Assessment of Butylene Oxide, Styrene Oxide, Methylbromide
  • F Rabbit: New Zealand White
  • Dose: 250 OR 1000 PPM 7HR/D