Testing Status of Agents at NTP
1,2-Dibromoethane
CASRN: 106-93-4
Formula: C2-H4-BR2
Synonyms/Common Names:
- EDB
- ETHYLENE DIBROMIDE
Known Uses:
SCAVENGER FOR LEAD IN GASOLINE; SOIL AND GRAIN FUMIGANT; INTERMEDIATE FOR DYES AND DRUGS
Nomination Background
Short-Term Toxicity
- 14-Day (Inhalation)
(C00522B) Completed
- NTIS No. PB82-181710
(Peer Review 06/27/1980)
Citation: Carcinogenesis Bioassay of 1,2-Dibromoethane (CAS No. 106-93-4) in F344 Rats and B6C3F1 Mice (Inhalation Study) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB82-181710
(Peer Review 06/27/1980)
- 13-WEEK (Gavage)
(C00522A) Completed
- NTIS No. PB288428
(Peer Review 04/26/1978)
Citation: Bioassay of 1,2-Dibromoethane for Possible Carcinogenicity (CAS No. 106-93-4) - Rats: Osborne Mendel; Mice: B6C3F1
- Dose: 0,40,251 MG/KG/5 PER GROUP
- NTIS No. PB288428
(Peer Review 04/26/1978)
- 13-Week (Inhalation)
(C00522B) Completed
- NTIS No. PB82-181710
(Peer Review 06/27/1980)
Citation: Carcinogenesis Bioassay of 1,2-Dibromoethane (CAS No. 106-93-4) in F344 Rats and B6C3F1 Mice (Inhalation Study) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,3,75 PPM/10R - 20M PER GROUP
- NTIS No. PB82-181710
(Peer Review 06/27/1980)
Long-Term Carcinogenicity
- 2-YEAR (Gavage)
(C00522A) Report Complete
- TR-086 (NTIS No. PB288428)
(Peer Review 04/26/1978)
Bioassay of 1,2-Dibromoethane for Possible Carcinogenicity (CAS No. 106-93-4) - Rats: Osborne Mendel; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Positive
- Female Mice Positive
- Dose: MR: 0,38,41 (AVG), FR: 0,37,39 (AVG), M: 0,62,107 MG/KG/50 PER GROUP
- TR-086 (NTIS No. PB288428)
(Peer Review 04/26/1978)
- 2-Year (Inhalation)
(C00522B) Report Complete
- TR-210 (NTIS No. PB82-181710)
(Peer Review 06/27/1980)
Carcinogenesis Bioassay of 1,2-Dibromoethane (CAS No. 106-93-4) in F344 Rats and B6C3F1 Mice (Inhalation Study) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Positive
- Female Mice Positive
- Dose: 0,10,40 PPM/50 PER GROUP
- TR-210 (NTIS No. PB82-181710)
(Peer Review 06/27/1980)
Special Studies
- Cell Proliferation
(S0762) Completed
- Citation: GHANAYEM, B.I., MARONPOT, R.R. & MATTHEWS, H.B. ASSOCIATION OF CHEMICALLY INDUCED FORESTOMACH CELL PROLIFERATION AND CARCINOGENESIS. CANCER LETTERS, 32 (1986) 271-278
- M Rats: F344/N
Genetic Toxicology
- Chromosome Aberrations
(738945) Completed
- Mice
- Chromosome Aberation Negative
- In Vitro Cytogenetics (CA/SCE)
(665769) Completed
- Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in Vitro IV: Results for l5 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Drosophila
(782145) Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
- Sex-Linked Recessive Lethal Positive
- Reciprocal Translocation Positive
- Mouse Lymphoma (NCI)
(G50253) Completed
- Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
- Mouse Lymphoma-NCI Positive
- Mouse Lymphoma (NCI)
(G62050) Completed
- Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
- Mouse Lymphoma-NCI Positive
- Micronucleus
(A71010) Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Positive
- Salmonella (NCI)
(N-9282) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Positive
- Salmonella
(529327) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Positive
- Sister Chromatid Exchanges
(738945) Completed
- Mice
- Sister Chromatid Positive (Nonstandard Protocol)
Organ Systems Toxicity
- Biochemical Specific Locus
(BSLM37) Completed
- Citation: Barnett, L.B., Felton, C.F., Gibson, B.J., Sharpe, D.S., Shelby, M.D., and Lewis, S.E. No heritable mutations are induced by ethylene dibromide at electrophoretically expressed loci. Mutation Res. 282:127-133 (1992).
- M Mice: DBA/2J
- Mice Male Negative
- Dominant Lethal (Male)
(DLM021) Completed
- Citation: Barnett, L.B., Felton, C.F., Gibson, B.J., Sharpe, D.S., Shelby, M.D., and Lewis, S.E. No heritable mutations are induced by ethylene dibromide at electrophoretically expressed loci. Mutation Res. 282:127-133 (1992).
- M Mice: DBA/2J
- Mice Male Negative
- Total Reproductive Capacity
(TRC98012) Completed
- Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns ofFemale Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
- F Mice
- Mice Female Negative
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