National Toxicology Program

CASRN: 1948-33-0

Formula: C10-H14-O2

Synonyms/Common Names:

• 1,4-BENZENEDIOL, 2-(1,1-DIMETHYLETHYL)
• MTBHQ

Known Uses:

ANTIOXIDANT IN VEGETABLE FATS AND OILS. INTERMEDIATE. (TDB)

Short-Term Toxicity

• 13-WEEK (Dosed-Feed)  (C62157) Completed 
  • NTIS No. PB98-107170  (Peer Review 06/20/1995)
    Citation: Toxicology and Carcinogenesis Studies oft-Butylhydroquinone (CAS No. 1948-33-0) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.25, 0.5, 1.0, 2.0, OR 4.0% IN FEED

Long-Term Carcinogenicity

• LIFETIME (Dosed-Feed)  (C62157) Report Complete 
  • TR-459 (NTIS No. PB98-107170)  (Peer Review 06/20/1995)
    Toxicology and Carcinogenesis Studies oft-Butylhydroquinone (CAS No. 1948-33-0) in F344 Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1; Rats: F344/N
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R&M: 0, 0.125, 0.25, OR 0.5% IN FEED; 70 RATS, 60 MICE

Genetic Toxicology

• Chromosome Aberrations  (A73022) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (089956) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Micronucleus  (A34876) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (663851) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Negative 
• Salmonella  (A71156) Completed 
  •  Inconclusive 

Organ Systems Toxicity

• Immunotoxicity (Gavage)  (IMM87036) Completed 
  • F Mice: B6C3F1
  • Dose: 0, 25, 75, 150 MG/KG