Summaries & Associations of Study Results
TR-486 Isoprene
Target Organs and Levels of Evidence
NTP Technical Report Number 486
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| ISOPRENE 78-79-5 |
12/10/97 | MONOMER AND COMONOMER FOR ELASTOMERS, PREPARED FROM TURPENTINE, PETROLEUM PRODUCTS (MERCK 1989) | Inhalation R: 0, 220, 700, OR 7000 PPM; 50/SEX/GROUP | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | MAMMARY GLAND: FIBROADENOMA 2/50 4/50 6/50 21/50 FIBROADENOMA OR CARCINOMA COMBINED 2/50 5/50 7/50 21/50 | |||
| KIDNEY TUBULAR CELL: (SINGLE SECTION) ADENOMA 0/50 2/50 2/50 6/50 (SINGLE AND STEP SECTION) ADENOMA 2/50 4/50 8/50 15/50 | ||||
| TESTIS: ADENOMA 33/50 37/50 44/50 48/50 | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: HYPERPLASIA | |||
| FR: SOME EVIDENCE | MAMMARY GLAND: FIBROADENOMA 19/50 35/50 32/50 32/50 MULTIPLE FIBROADENOMA 7/50 12/50 19/50 17/50 | |||
| MAY HAVE BEEN RELATED: | BRAIN: ASTROCYTOMA 0/50 0/50 1/50 0/50, GLIOMA 0/50 0/50 0/50 1/50, MEDULOBLASTOMA 0/50 0/50 0/50 1/50, MENINGEAL GRANULAR CELL TUMOR 0/50 1/50 0/50 1/50, MENINGEAL SARCOMA 0/50 1/50 0/50 1/50 | |||
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