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Department of Transfusion Medicine at the NIH Clinical Center
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Clinical Ordering Guide
 
  • DTM Laboratory
Information
 
  • Ordering
 
  • Specimen
Collection &
Transport
 
  • Reporting Results  
  • Consultation
Services
 
  • Transfusion
Practices
 
  • Blood Component
Pick Up
 
  • Patient
Preparation
 
  • Adverse
Reactions to
Transfusion
 
  • Blood Donations
 
   

Therapy for Adverse Reactions to Transfusion

Reactions Procedures
Urticaria Only Discontinue transfusion, give antihistamines IV and
resume transfusion if therapy is effective.
Fever, Chills STOP TRANSFUSION but keep IV line open. Notify DTM.
For Reactions Involving Red Blood Cellsor Granulocytes

Collect Red top and Lavender top tubes from patient, being careful to avoid hemolysis.

Sign and date the samples. (No Typenex needed)

Send samples to DTM along with blood container and intact recipient set.

Obtain urine sample and send to DTM for determination of free hemoglobin.

If laboratory tests or clinical conditions indicate,
start prophylactic treatment as outlined below.

Shock, Hemoglobinuria, Oliguria, Bleeding, Lumbar Pain, Dyspnea,Chest Pain

STOP TRANSFUSION but keep IV line open. Notify DTM.

INSTITUTE PROPHYLACTIC TREATMENT IMMEDIATELY

•Maintain blood pressure

•Maintain urine flow over 70 mL/hr

•Push fluids; keep strict I & O

•IV diuretic, e.g., furosemide (Lasix)

Collect Red top and Lavender top tubes, being careful to avoid hemolysis. Sign and date tubes.

Send Red top and Lavender top tubes to DTM along with blood container and intact recipient set.

Obtain urine sample and send to DTM.

Obtain specimens for CBC, PT, PTT, TT, fibrinogen, platelet count, bilirubin, BUN, LDH, creatinine and electrolytes.

Consult DTM physician about further therapy.

Acute Anaphylaxis

STOP TRANSFUSION but keep IV line open. Notify DTM.

Inject Epinephrine: 0.4 mL of 1:1000 solution for adults, 0.2 mL of 1:1000 solution for children SQ (unless severe shock prevents absorption); then give same dose diluted 10 mL in normal saline IV over 5minutes.

Collect Red top and Lavender top tubes, being careful to avoid hemolysis. Sign and date tubes.

Send tubes and blood container with intact recipient set to DTM.

Consider bacterial contamination or antibodies to IgA in further evaluation and treatment.

   
   
   


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