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Selected Publications

Environmental Stress & Cancer Group

  1. Bredemeyer AL, Helmink BA, Innes CL, Calderon B, McGinnis LM, Mahowald GK, Gapud EJ, Walker LM, Collins JB, Weaver BK, Mandik-Nayak L, Schreiber RD, Allen PM, May MJ, Paules RS, Bassing CH, Sleckman BP. 2008. DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature 456 (7223):819-823. [Abstract] ( Exit NIEHS
  2. Lobenhofer EK, Auman JT, Blackshear PE, Boorman GA, Bushel PR, Cunningham ML, Fostel JM, Gerrish K, Heinloth AN, Irwin RD, Malarkey DE, Merrick BA, Sieber SO, Tucker CJ, Ward SM, Wilson RE, Hurban P, Tennant RW, Paules RS. 2008. Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype. Genome Biology 9 (6):R100. [Abstract] ( Exit NIEHS
  3. Arlander SJH, Greene BT, Innes CL, Paules RS. 2008. DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells. Cancer Research 68 (1):89-97. [Abstract] ( Exit NIEHS
  4. Bushel PR, Heinloth AN, Li J, Huang L, Chou JW, Boorman GA, Malarkey DE, Houle CD, Ward SM, Wilson RE, Fannin RD, Russo MW, Watkins PB, Tennant RW, Paules RS. 2007. Blood gene expression signatures predict exposure levels. Proceedings of the National Academy of Sciences of the United States of America 104(46):18211-18216. [Abstract] ( Exit NIEHS
  5. Chou JW, Zhou T, Kaufmann WK, Paules RS, Bushel PR. 2007. Extracting gene expression patterns and identifying co-expressed genes from microarray data. BMC bioinformatics 8(1):427-427. [Abstract] ( Exit NIEHS
  6. Auman J.T., G.A. Boorman, R.E. Wilson, G.S. Travlos, and R.S. Paules. 2007. Heat map visualization of high-density clinical chemistry data. Physiological Genomics, 2 352-356. [Abstract] ( Exit NIEHS
  7. Innes, C.L., A.N. Heinloth, K.G. Flores, S.O. Sieber, P.B. Deming, P.R. Bushel, W.K Kaufmann, and R.S. Paules. 2006. ATM requirement in gene expression responses to ionizing radiation in human lymphoblasts and fibroblasts. Mol. Cancer Res., 4, 197-207. [Abstract] ( Exit NIEHS
  8. Members of the Toxicogenomics Research Consortium. 2005. Standardizing global gene expression analysis between laboratories and across platforms. Nat. Methods, 2, 351-356. [Abstract] ( Exit NIEHS
  9. Fannin, R.D., J.T. Auman, M.E. Bruno, S.O. Sieber, S.M. Ward, C.J. Tucker, B.A. Merrick, and R.S. Paules. 2005. Differential gene expression profiling in whole blood during acute systemic inflammation in lipopolysaccharide-treated rats. Physiol. Genomics, 21, 92-104.  [Abstract] ( Exit NIEHS
  10. Heinloth, A.N., R.D. Irwin, G.A. Boorman, P. Nettesheim, R.D. Fannin, S.O. Sieber, M.L. Snell, C. J. Tucker, L. Li, G.S. Travlos, G. Vansant, P.E. Blackshear, R.W. Tennant, M.L. Cunningham, and R.S. Paules. 2004. Gene expression profiling of rat livers reveals indicators of potential adverse effects. Toxicol. Sci., 80, 193-202. [Abstract] ( Exit NIEHS
  11. Heinloth, A.N., R.E. Shackelford, C.L. Innes, L. Bennett, L. Li, R.P. Amin, S.O. Sieber, K.G. Flores, P.R. Bushel, and R.S. Paules. 2003. Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation. Mol. Carcinog., 37, 65-82. [Abstract] ( Exit NIEHS
  12. Heinloth, A.N., R.E. Shackelford, C.L. Innes, R.P. Amin, S.O. Sieber, K.G. Flores, L. Bennett, P.R. Bushel, and R.S. Paules. 2003. ATM-dependent and ATM-independent gene expression changes in response to oxidative stress, γ-radiation and UV-radiation. Rad. Res., 160, 273-290. [Abstract] ( Exit NIEHS
  13. Harding, H.P, Y. Zhang, H. Zeng, I. Novoa, P.D. Lu, B. Popko, R.S. Paules, T. Hettmann, J.M. Leiden, and D. Ron. 2003. An integrated stress response promotes resistance to oxidative stress through amino acid sufficiency. Mol. Cell, 11, 619-633. [Abstract] ( Exit NIEHS
  14. Heffernan, T.P., D.A. Simpson, A.R. Frank, A.N. Heinloth, R.S. Paules, M. Cordeiro-Stone, and W.K. Kaufmann. 2002. An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage. Mol. Cell. Biol., 22, 8552-8561. [Abstract] ( Exit NIEHS
  15. Flores, K.G., P.B. Deming, C.S. Downes, R.S. Paules, and W.K. Kaufmann. 2002. ATR enforces the topoisomerase II-dependent G2 checkpoint through Plk1 kinase. J. Biol. Chem., 277, 36832-36838.
  16. Hamadeh, H.K., P.R. Bushel, S. Jayadev, K. Martin, O. DiSorba, S. Sieber, L. Bennett, R. Tennant, R. Stoll, J.C. Barrett, K. Blanchard, R.S. Paules, and C.A. Afshari. 2002. Gene expression analysis reveals chemical-specific profiles. Toxicol. Sci., 67, 219-231.  [Abstract] ( Exit NIEHS
  17. Wolfinger, R.D., G. Gibson, E.D. Wolfinger, L. Bennett, H. Hamadeh, P. Bushel, C.A. Afshari, and R.S. Paules. 2001. Assessing gene significance from cDNA microarray expression data via mixed models. J. Comp. Biol., 8, 625-637. [Abstract] ( Exit NIEHS
  18. Shackelford, R.E, C.L. Innes, S.O. Sieber, A.N. Heinloth, S.A. Leadon, and R.S. Paules. 2001. The ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts. J. Biol. Chem., 276, 21951-21959. [Abstract] ( Exit NIEHS
  19. Shackelford, R.E., W.K. Kaufmann, and R.S. Paules. 2000. Oxidative stress and cell cycle checkpoint function. Free Radic. Biol. Med., 28, 1387-1404. [Abstract] ( Exit NIEHS
  20. Kaufmann, W.K. and R.S. Paules. 1996. DNA damage and cell cycle checkpoints. The FASEB J., 10, 238-247. [Abstract] ( Exit NIEHS
  21. Paules, R.S., E.N. Levedakou, S.J. Wilson, C.L. Innes, N. Rhodes, T.D. Tlsty, D.A. Galloway, L.A. Donehower, M.A. Tainsky, and W.K. Kaufmann. 1995. Defective G2 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res., 55, 1763-1773. [Abstract] ( Exit NIEHS

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Last Reviewed: January 12, 2009