Testing Status of Agents at NTP
Lauric acid diethanolamine condensate
CASRN: 120-40-1
Formula: C16-H33-N-O3
Synonyms/Common Names:
- DODECANAMIDE, N,N-BIS(2-HYDROXYETHYL)- (8CI) (9CI)
Known Uses:
FOAM STABILIZER FOR LIQUID HOUSEHOLD DETERGENTS AND SHAMPOOS. (TDB)
Short-Term Toxicity
- 13-WEEK (Topical Application)
(C55323B) Completed
- NTIS No. PB99-169989
(Peer Review 12/10/1997)
Citation: Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CAS No. 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 25, 50, 100, 200, OR 400 MG/KG; 20/SEX/GROUP M: 0, 50, 100, 200, 400, OR 800 MG/KG; 10/SEX/GROUP
- NTIS No. PB99-169989
(Peer Review 12/10/1997)
Long-Term Carcinogenicity
- 2-YEAR (Topical Application)
(C55323B) Report Complete
- TR-480 (NTIS No. PB99-169989)
(Peer Review 12/10/1997)
Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CAS No. 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice Some Evidence
- Dose: R: 0, 50, OR 100 MG/KG M: 0, 100, OR 200 MG/KG (50/SEX/SPECIES/GROUP)
- TR-480 (NTIS No. PB99-169989)
(Peer Review 12/10/1997)
Special Studies
- Absorption Disposition Metabolism Elimination (Intravenous; Gavage; Topical Application)
(S0611) Completed
- Citation: MATHEWS, J.M., DECOSTA, K AND THOMAS, B.F., LAURAMIDE DIETHANOLAMINE ABSORPTION, METABOLISM & DISPOSITION IN RATS & MICE AFTER ORAL, IV & DERMAL ADMIN, DRUG MET & DISPOSITION 24(7):702, 1996
- M Rats: F344/N; M Mice: B6C3F1; M Rats: F344/N; M Rats: F344/N; M Mice: B6C3F1
- Dose: gav: rats: 1000 mg/kg, sp: rats: 25 and 400 mg/kg, mice: 50, 100, 200, and 800 mg/kg, iv: rats: 25 mg/kg, mice: 50 mg/kg
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(836554) Completed
- Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- Mouse Lymphoma
(920902) Completed
- Negative
- Micronucleus
(A82445) Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(854154) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Negative
Web page last updated on January 22, 2009