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Our Science – Yang Website

De Yang, M.D., Ph.D.

Selected Publications
1)  Zhang N, Yang D, Dong H, Chen Q, Dimitrova DI, Rogers TJ, Sitkovsky M, Oppenheim JJ.
Adenosine A2a receptors induce heterologous desensitization of chemokine receptors.
Blood. 108: 38-44, 2006. [Journal]
2)  Wang ZY, Yang D, Chen Q, Leifer CA, Segal DM, Su SB, Caspi RR, Howard ZO, Oppenheim JJ.
Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.
Exp. Hematol. 34: 1115-24, 2006. [Journal]
3)  Oppenheim JJ, Yang D.
Alarmins: chemotactic activators of immune responses.
Curr. Opin. Immunol. 17: 359-65, 2005. [Journal]
4)  Kurosaka K, Chen Q, Yarovinsky F, Oppenheim JJ, Yang D.
Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant.
J. Immunol. 174: 6257-65, 2005. [Journal]
5)  Yang D, Oppenheim JJ.
Antimicrobial proteins act as.
Arthritis Rheum. 50: 3401-3, 2004. [Journal]
6)  Chen B, Blair DG, Plisov S, Vasiliev G, Perantoni AO, Chen Q, Athanasiou M, Wu JY, Oppenheim JJ, Yang D.
Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis.
J. Immunol. 173: 5914-7, 2004. [Journal]
7)  Yang D, Chen Q, Rosenberg HF, Rybak SM, Newton DL, Wang ZY, Fu Q, Tchernev VT, Wang M, Schweitzer B, Kingsmore SF, Patel DD, Oppenheim JJ, Howard OM.
Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation.
J. Immunol. 173: 6134-42, 2004. [Journal]
8)  Yang D, Biragyn A, Hoover DM, Lubkowski J, Oppenheim JJ.
Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense.
Annu. Rev. Immunol. 22: 181-215, 2004. [Journal]
9)  Chen Q, Wade D, Kurosaka K, Wang ZY, Oppenheim JJ, Yang D.
Temporin A and related frog antimicrobial peptides use formyl peptide receptor-like 1 as a receptor to chemoattract phagocytes.
J. Immunol. 173: 2652-9, 2004. [Journal]
10)  Wu Z, Hoover DM, Yang D, Boulègue C, Santamaria F, Oppenheim JJ, Lubkowski J, Lu W.
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3.
Proc. Natl. Acad. Sci. U.S.A. 100: 8880-5, 2003. [Journal]
11)  Yang D, Rosenberg HF, Chen Q, Dyer KD, Kurosaka K, Oppenheim JJ.
Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells.
Blood. 102: 3396-403, 2003. [Journal]
12)  Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J, Oppenheim JJ.
Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
J. Leukoc. Biol. 74: 448-55, 2003. [Journal]
13)  Oppenheim JJ, Biragyn A, Kwak LW, Yang D.
Roles of antimicrobial peptides such as defensins in innate and adaptive immunity.
Ann. Rheum. Dis. 62 Suppl 2: ii17-21, 2003. [Journal]
14)  Oppenheim JJ, Yang D, Biragyn A, Howard OM, Plotz P.
Chemokine receptors on dendritic cells promote autoimmune reactions.
Arthritis Res. 4 Suppl 3: S183-8, 2002. [Journal]
15)  Howard OM, Dong HF, Yang D, Raben N, Nagaraju K, Rosen A, Casciola-Rosen L, Härtlein M, Kron M, Yang D, Yiadom K, Dwivedi S, Plotz PH, Oppenheim JJ.
Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells.
J. Exp. Med. 196: 781-91, 2002. [Journal]
16)  Yang D, Chen Q, Gertz B, He R, Phulsuksombati M, Ye RD, Oppenheim JJ.
Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation.
J. Leukoc. Biol. 72: 598-607, 2002. [Journal]
17)  Yang D, Biragyn A, Kwak LW, Oppenheim JJ.
Mammalian defensins in immunity: more than just microbicidal.
Trends Immunol. 23: 291-6, 2002. [Journal]
18)  Hoover DM, Boulegue C, Yang D, Oppenheim JJ, Tucker K, Lu W, Lubkowski J.
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.
J. Biol. Chem. 277: 37647-54, 2002. [Journal]
19)  Yang D, Chen Q, Le Y, Wang JM, Oppenheim JJ.
Differential regulation of formyl peptide receptor-like 1 expression during the differentiation of monocytes to dendritic cells and macrophages.
J. Immunol. 166: 4092-8, 2001. [Journal]
20)  Yang D, Chertov O, Oppenheim JJ.
Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37).
J. Leukoc. Biol. 69: 691-7, 2001. [Journal]
21)  Yang D, Chertov O, Oppenheim JJ.
The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity.
Cell. Mol. Life Sci. 58: 978-89, 2001. [Journal]
22)  Chen X, Yang D, Shen W, Dong HF, Wang JM, Oppenheim JJ, Howard MZ.
Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors.
Inflamm. Res. 49: 744-55, 2000. [Journal]

This page was last updated on 8/29/2006.