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Selected Publications

Free Radical Metabolism Group

  1. Brimfield AA, Mancebo AM, Mason RP, Jiang J, Sirak AG, Novak MJ.: Free radical production from the interaction of 2-chloroethyl vesicants (mustard gas) with pyridine nucleotide-driven flavoprotein electron transport systems. Toxicology and applied pharmacology 234(1):128-134, 2009. [Abstract] Exit NIEHS
  2. Ramirez DC, Gomez-Mejiba SE, Corbett JT, Deterding LJ, Tomer KB, Mason RP.: Cu,Zn-superoxide dismutase-driven free radical modifications: copper- and carbonate radical anion-initiated protein radical chemistry. Biochem J. 417(1):341-53. 2009. [Abstract] Exit NIEHS
  3. Bonini MG, Stadler K, Silva SO, Corbett J, Dore M, Petranka J, Fernandes DC, Tanaka LY, Duma D, Laurindo FRM, Mason RP. Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation. Proceedings of the National Academy of Sciences of the United States of America 105(25):8569-8574, 2008. [Abstract] ( Exit NIEHS
  4. Cassina P, Cassina A, Pehar M, Castellanos R, Gandelman M, de León A, Robinson KM, Mason RP, Beckman JS, Barbeito L, Radi R.: Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J Neurosci. 28(16):4115-22. 2008. [Abstract] Exit NIEHS
  5. Connor HD, Sturgeon BE, Mottley C, Sipe HJ, Mason RP. L-tryptophan radical cation electron spin resonance studies: connecting solution-derived hyperfine coupling constants with protein spectral interpretations. J Am Chem Soc. 130: 6381-6387, 2008. [Abstract] ( Exit NIEHS
  6. Chatterjee S, Ehrenshaft M, Bhattacharjee S, Deterding LJ, Bonini MG, Corbett J, Kadiiska M, Tomer KB, Mason RP. : Immunospin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice. Free Radic Biol Med. 2008. [Abstract] Exit NIEHS
  7. Lardinois, O.M., Detweiler, C.D. , Tomer, K.B., Mason, R.P., Deterding, L.J. Identifying the site of spin trapping in proteins by a combination of liquid chromatography, ELISA and off-line tandem mass spectrometry. Free Radical Biology & Medicine 44(5):893-906; 2008. [Abstract] ( Exit NIEHS
  8. Lardinois OM, Tomer KB, Mason RP, Deterding LJ. : Identification of protein radicals formed in the human neuroglobin-H2O2 reaction using immuno-spin trapping and mass spectrometry. Biochemistry. 47(39):10440-8. 2008. [Abstract] Exit NIEHS
  9. Liu J, Qian SY, Guo Q, Jiang J, Waalkes MP, Mason RP, Kadiiska MB.: Cadmium generates reactive oxygen- and carbon-centered radical species in rats: insights from in vivo spin-trapping studies. Free Radic Biol Med. 45(4):475-81. 2008. [Abstract] Exit NIEHS
  10. Ranguelova K, Suarez J, Magliozzo RS, Mason RP. Immuno-spin investigation of peroxide- and isoniazid-induced radicals in mycobacterium tuberculosis catalase-peroxidase. Biochemistry 47(43):11377-11385, 2008. [Abstract] ( Exit NIEHS
  11. Rehman, H., Connor, H.D., Ramshesh, V.K., Theruvath, T.P., Mason, R.P. , Wright, G.L., Lemasters, J.J., Zhong, Z. Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation 85(9):1322-1331; 2008. [Abstract] ( Exit NIEHS
  12. Siraki, A.G., Deterding, L., Bonini, M.G., Jiang, J.J., Ehrenshaft, M., Mason, R.P. Procainamide but not N-acetylprocainamide induces protein free radical formation on myeloperoxidase: A potential mechanism of agranulocytosis. Chemical Research in Toxicology 21(5):1143-1153, 2008. [Abstract] ( Exit NIEHS
  13. Stadler K, Bonini MG, Dallas S, Jiang JJ, Radi R, Mason RP, Kadiiska M. Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free radical biology & medicine 45(6):866-874, 2008. [Abstract] ( Exit NIEHS
  14. Stadler K, Bonini MG, Dallas S, Duma, D, Mason RP, Kadiiska MB. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. American journal of physiology. Endocrinology and metabolism 295(2):E456-E462, 2008. [Abstract] ( Exit NIEHS
  15. Bhattacharjee, S., Deterding, L.J., Jiang, J.J., Bonini, M.G., Tomer, K.B., Ramirez, D.C., Mason, R.P. Electron transfer between a tyrosyl radical and a cysteine residue in hemoproteins: spin trapping analysis. Journal of the American Chemical Society 129(44):13493-13501; 2007. [Abstract] ( Exit NIEHS
  16. Bonini, M.G., Siraki, A.G., Atanassov, B.S., Mason, R.P. Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes. Free Radical Biol. Med. 42:530-540; 2007.  [Abstract] ( Exit NIEHS
  17. Bonini, M.G., Siraki, A.G., Bhattacharjee, S., Mason, R.P. Glutathione-induced radical formation on lactoperoxidase does not corelate with the enzyme’s peroxidase activity. Free Radical Biol. Med. 42:985-992; 2007.  [Abstract] ( Exit NIEHS
  18. Deterding LJ, Bhattacharjee S, Ramirez DC, Mason RP, Tomer KB.: Top-down and bottom-up mass spectrometric characterization of human myoglobin-centered free radicals induced by oxidative damage. Anal Chem. 79(16):6236-48. 2007. (Abstract) [Abstract] Exit NIEHS
  19. Jiang, J.J., Corbett, B.J., Hogg, N., Mason, R.P. An electron paramagnetic resonance investigation of the oxygen dependence of the arterial-venous gradient of nitrosyl hemoglobin (HbNO) in blood circulation. Free Radical Biology & Medicine 8:1208-1215; 2007. [Abstract] ( Exit NIEHS
  20. Ramirez, D.C., Gomez-Mejiba, S.E., Mason, R.P. Immuno-spin trapping analyses of DNA radicals. Nature Protocols 2:512-522; 2007.  [Abstract] ( Exit NIEHS
  21. Siraki AG, Bonini MG, Jiang J, Ehrenshaft M, Mason RP.: Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol. 20(7):1038-45. 2007. [Abstract] Exit NIEHS
  22. Woods, C.G., Burns, A.M., Maki, A., Bradford, B.U., Cunningham, M.L., Connor, H.D., Kadiiska, M.B., Mason, R.P., Peters, J.M., Rusyn, I. Sustained formation of α-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-α, but not NADPH oxidase. Free Radical Biol. Med. 42:335-342; 2007.  [Abstract] ( Exit NIEHS
  23. Bonini, M.G., Rota, C., Tomasi, A., Mason, R.P. The oxidation of 2’,7’-dichlorofluorescin to reactive oxygen species: A self-fulfilling prophesy? Free Radical Biol. Med. 40: 968- 975; 2006. [Abstract] ( Exit NIEHS
  24. Ehrenshaft, M., Mason, R.P. Protein radical formation on thyroid peroxidase during turnover as detected by immuno-spin trapping. Free Radical Biol. Med. 41: 422-430; 2006. [Abstract] ( Exit NIEHS
  25. Keszler, A., Mason, R.P., Hogg, N. Immuno-spin trapping of hemoglobin and myoglobin radicals from nitrite-mediated oxidation. Free Radical Biol. Med. 40: 507-515; 2006. [Abstract] ( Exit NIEHS
  26. Kono, H., Woods, C.G., Maki, A., Connor, H.D., Mason, R.P., Rusyn, I., Fujii, H. Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. Free Rad. Res. 40:579-588; 2006. [Abstract] ( Exit NIEHS
  27. Nakai, K., Kadiiska, M.B., Jiang, J.-J., Stadler, K., Mason, R.P. Free Radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin. Natl. Acad. Sci. USA.103: 4616-4621; 2006. [Abstract] ( Exit NIEHS
  28. Ramirez, D.C., Gomez Mejiba, S.E., Mason, R.P. Immuno-spin trapping of DNA radicals. Nature Methods 3 (2): 123-127; 2006. [Abstract] ( Exit NIEHS
  29. Zhong, Z., Connor, H.D., Li, X., Mason, R.P., Forman, D.T., Lemasters, J.J., Thurman, R.G. Reduction of ciclosporin and tacrolimus nephrotoxicity by plant polyphenols. J. Pharm. Pharmacol. 58:1533-1543; 2006. [Abstract] ( Exit NIEHS
  30. Arimoto T., Kadiiska M.B., Sato K., Corbett J., Mason R.P. Synergistic production of lung free radicals by diesel exhaust particles and endotoxin. Am. J. Respir. Crit. Care Med. 171: 379-387, 2005. [Abstract] ( Exit NIEHS
  31. Detweiler C.D., Lardinois O.M., Deterding L.J., Ortiz de Montellano P.R., Tomer K.B., Mason R.P. Identification of the myoglobin tyrosyl radical by immuno-spin trapping and its dimerization. Free Radic. Biol. Med. 38: 969-976; 2005. [Abstract] ( Exit NIEHS
  32. Dikalov S., Jiang J., Mason R.P. Characterization of the high-resolution ESR spectra of superoxide radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide (DEPMPO) and 5,5-dimethyl-1-pyrroline N-oxide (DMPO). Analysis of conformation exchange. Free Radic. Res. 39(8): 825-836; 2005. [Abstract] ( Exit NIEHS
  33. Kadiiska, M.B., Gladen, B.C., Baird, D.D., Germolec, D., Graham, L.B., Parker, C.E., Nyska, A., Wachsman, J.T., Ames, B.N., Basu, S., Brot, N., FitzGerald, G.A., Floyd, R.A., George, M., Heinecke, J.W., Hatch, G.E., Hensley, K., Lawson, J.A., Marnett, L.J., Morrow, J.D., Murray, D.M., Plastaras, J., Roberts, L.J., Rokach, J., Shigenaga, M.K., Sohal, R.S., Sun, J., Tice, R.R., Van Thiel, D.H., Wellner, D., Walter, P.B., Tomer, K.B., Mason, R.P., Barrett, J.C. Biomarkers of Oxidative Stress Study II. Are Oxidation Products of Lipids, Proteins and DNA Markers in CCl4 Poisoning? Free Radical Biol. Med. 38: 698-710, 2005. [Abstract] ( Exit NIEHS
  34. Kadiiska, M.B., Gladen, B.C., Baird, D.D., Graham, L.B., Parker, C.E., Ames, B.N., Basu, S., FitzGerald, G.A., Lawson, J.A., Marnett, L.J., Morrow, J.D., Murray, D.M., Plastaras, J., Roberts, L.J., Rokach, J., Shigenaga, M.K., Sun, J., Walter, P.B., Tomer, K.B., Barrett, J.C., Mason, R.P. Biomarkers of Oxidative Stress Study III. Effects of the Non-Steroidal Anti-Inflammatory Agents Indomethacin and Meclofenamic acid on Measurements of Oxidative Products of Lipids in CCl4 Poisoning. Free Radical Biol. Med. 38: 711-718, 2005. [Abstract] ( Exit NIEHS
  35. Nakai, Kozo and Mason, R.P. Immunochemical detection of nitric oxide and nitrogen dioxide trapping of the tyrosyl radical and the resulting nitrotyrosine in sperm whale myoglobin. Free Radical Biol. Med. 39:1050-1058; 2005. [Abstract] ( Exit NIEHS
  36. Qian, S.Y., Kadiiska M.B., Guo, Q., Mason R.P. A novel protocol to identify and quantify all spin trapped free radicals from in vitro/in vivo interaction of HO• and DMSO: LC/ESR, LC/MS, and dual spin trapping combinations. Free Radic. Biol. Med. 38: 125-135, 2005. [Abstract] ( Exit NIEHS
  37. Ramirez D.C., Gomez Mejiba S.E., Mason R.P. Copper-catalyzed protein oxidation and its modulation by carbon dioxide: enhancement of protein radicals in cells. J. Biol. Chem. 280: 27402-27411; 2005. [Abstract] ( Exit NIEHS
  38. Ramirez, D.C., Gomez Mejiba, S.E., Mason, R.P. Mechanism of hydrogen peroxide-induced Cu, Zn-superoxide dismutase-centered radical formation as explored by immuno-spin trapping. Free Radical Biol. Med. 38: 201-214, 2005. [Abstract] ( Exit NIEHS
  39. Zhong Z., Conner H.D., Frosh M., Bunzedahl H., Lind H., Lehnert M., Mason R.P., Thurman R.G., Lemasters J.J. Free radical-dependent dysfunction of small-for-size rat liver grafts: prevention by plant polyphenols. Gastroenterology 129: 652-664; 2005. [Abstract] ( Exit NIEHS

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Last Reviewed: January 12, 2009