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Selected Publications

Transmembrane Signaling Group

  1. Brunk I, Blex C, Sanchis-Segura C, Sternberg J, Perreau-Lenz S , Bilbao A, Hörtnag H, Baron J , Juranek J, Laube G, Birnbaumer L, Spanagel R, Ahnert-Hilger G. (2008) "Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system." The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22(10), 3736-3746. [Abstract] ( Exit NIEHS
  2. Hartmann, J., Dragicevic, E., Adelsberger, H., Henning, H., Sumser, M., Abramowitz, J., Blum, R., Dietrich, A., Freichel, M., Flockerzi, V., Birnbaumer, L., Konnerth, A. (2008) "TRPC3 channels are required for synaptic transmission and motor coordination." Neuron. USA 59(3), 392-398. [Abstract] ( Exit NIEHS
  3. Jin, Y.Z., Thompson, B.D., Zhou, Z.Y., Fu, Y., Birnbaumer, L., Wu, M.X. (2008) "Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease." Eur. J. Immunol. USA 38(7), 1988-1998. [Abstract]( Exit NIEHS
  4. Chaudhuri, P., Colles, S.M., Bhat, M., Van Wagoner, D.R., Birnbaumer, L., Graham, L.M. (2008) "Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement." Mol. Bio. Cell. USA 19(8), 3203-3211.  [Abstract] ( ) Exit NIEHS
  5. Abramowitz, J., Grenet, D., Birnbaumer, M., Torres, H.N. and Birnbaumer, L. (2004) "XLαs, the Extralong Form of the α Subunit of the Gs G Protein is Significantly Longer than Suspected, and So is Its Companion Alex." Proc. Natl. Acad. Sci. USA 100, 8366-8371.  [Abstract] ( Exit NIEHS
  6. Erxleben, C., Liao, Y., Gentile, S., Chin, D., Gomez-Alegria, C., Mori, Y., Birnbaumer, L. and Armstrong, D. (2006) "Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices." Proc. Natl. Acad. Sci. USA 103, 3932-3937.  [Abstract] ( Exit NIEHS
  7. Gohla, A., Klement, K., Piekorz, R.P., Pexa, K., vom Dahl, S., Spicher, K., Dreval, V., Häussinger, D., Birnbaumer, L. and Nürnberg, B. (2007) "An obligatory requirement for the heterotrimeric G protein Gi3 in the anti-autophagic action of insulin in the liver." Proc. Nat. Acad. Sci. USA 104, 3003-3008.  [Abstract] ( Exit NIEHS
  8. Liao, Y.H., Erxleben, C., Yildirim, E., Abramowitz, J., Armstrong, D. and Birnbaumer, L. (2007) "Orai proteins interact with TRPC channels Orai proteins interact with TRPC channels and confer responsiveness to store depletion." Proc. Nat. Acad. Sci. USA 104, 4682-4687.  [Abstract] ( Exit NIEHS
  9. Liu, X., Cheng, K.T., Bandyopadhyay, B.C., Pani, B., Dietrich, A., Paria, B.C., Swaim, W.D., Beech, D., Yildirim,E., Singh, B.B., Birnbaumer, L. and Ambudkar, I.S. (2007) "Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice." Proc. Natl. Acad. Sci. USA 104, 17542-17547.  [Abstract] ( Exit NIEHS
  10. Thompson, B.D., Jin, Y., Wu, K.H., Colvin, R.A., Luster, A.D., Birnbaumer, L., Wu, M.X. (2007) "Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling." The Journal of Biological Chemistry 282(13), 9547-9555. [Abstract] ( Exit NIEHS
  11. Padigel UM, Stein L, Redding K, Lee JJ, Nolan TJ, Schad GA, Birnbaumer L, Abraham D. (2007) "Signaling through Gai2± protein is required for recruitment of neutrophils for antibody-mediated elimination of larval Strongyloides stercoralis in mice." Journal of leukocyte biology 81(4):1120-1126. [Abstract] ( Exit NIEHS
  12. Liao, Y.H,, Erxleben, C., Abramowitz, J., Flockerzi, V., Zhu, M.X., Armstrong, D.L. and Birnbaumer, L. (2008) "Functional interactions among Orai1, TRPCs and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac." Proc. Natl. Acad. Sci. USA 105(8), 2895-2900.  [Abstract] ( Exit NIEHS
  13. Zurita A., and Birnbaumer L. (2008) "The same mutation in Gsalpha and transducin (alpha) reveals behavioral differences between these highly homologous G protein alpha-subunits." Proc. Natl. Acad. Sci. USA 105(7), 2363-2368. [Abstract] ( Exit NIEHS
  14. Edwards RA, Wang K, Davis JS, Birnabumer L . (2008) "Role for epithelial dysregulation in early-onsert colitis-assocaited colon cancer in Gi2-/- mice." Inflammatory bowel diseases14(7):898-907. [Abstract] ( Exit NIEHS


  1. Birnbaumer, L., Yildirim, E. and Abramowitz, J. (2003) "A Comparison of the Genes Coding for Canonical TRP Channels and Their M, V and D Relatives." Cell Calcium 33, 419-432.  [Abstract] ( Exit NIEHS
  2. Birnbaumer, L. (2007) "The discovery of signal transduction by G proteins. A personal account and an overview of the initial findings and contributions that led to our present understanding." Biochim. Biophys. Acta. Biomembranes 1768, 756-771.  [Abstract] ( Exit NIEHS
  3. Birnbaumer, L. (2007) "Expansion of signal transduction by G proteins from 3 to 16 α subunits plus βγ dimers. The second 15 years or so..." Biochim. Biophys. Acta Biomembranes 1768, 772-793.  [Abstract] ( Exit NIEHS

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