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Selected Publications

Medicinal Chemistry Group

  1. Li Q, Okada Y, Wilson WA, Lazarus LH, Swartzwelder HS. The novel micro-opioid receptor antagonist [N-allyl-Dmt1]-endomorphin-2 attenuates the enhancement of GABAergic neurotransmission by ethanol. Alcohol and alcoholism (Oxford, Oxfordshire) 2009 44(1):13-19. [Abstract] ( Exit NIEHS
  2. Vergura R, Balboni G, Spagnolo B, Gavioli E, Lambert DG, McDonald J, Trapella C, Lazarus LH, Regoli D, Guerrini R, Salvadori S, Calo G. Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist. Peptides 2008 29(1):93-103. [Abstract] ( Exit NIEHS
  3. Koda Y, Del Borgo M, Wessling ST, Lazarus LH , Okada Y , Toth I, Blanchfield JT. Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides. Bioorganic & medicinal chemistry 2008 16(11):6286-6296. [Abstract] ( Exit NIEHS
  4. Shiotani K, Li T, Miyazaki A, Tsuda Y, Bryant SD, Ambo A, Sasaki Y, Lazarus LH, Okada Y. Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity. Bioorganic & medicinal chemistry letters 2006 16(22):5793-5796. [Abstract] ( Exit NIEHS
  5. Balboni G, Onnis V, Congiu C, Zotti M, Sasaki Y, Ambo A, Bryant SD, Jinsmaa Y, Lazarus LH, Lazaari I, Trapella C, Salvadori S. Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. Journal of Medicinal Chemistry 2006 49(18):5610-5617. [Abstract] ( Exit NIEHS
  6. Neumeyer JL , Peng X , Knapp BI , Bidlack JM , Lazarus LH , Salvadori S , Trapella C , Balboni G. New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. Journal of Medicinal Chemistry 2006 49(18):5640-5643. [Abstract] ( Exit NIEHS
  7. Shiotani K, Li T, Miyazaki A, Tsuda Y, Yokoi T, Ambo A, Sasaki Y, Bryant SD, Lazarus LH, Okada Y. Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform. Bioorganic & Medicinal Chemistry Letters 2007 21: 5768-5771. [Abstract] ( Exit NIEHS
  8. Balboni G, Onnis V, Congiu C, Zotti M, Sasaki Y, Ambo A, Bryant SD, Jinsmaa Y, Lazarus LH, Lazzari I, Trapella C, Salvadori S. Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore. Bioorganic & Medicinal Chemistry 2007 15(9):3143-3151. [Abstract] ( Exit NIEHS
  9. Salvadori S, Fiorini S, Trapella C, Porreca F, Davis P, Sasaki Y, Ambo A, Marczak ED, Lazarus LH, Balboni G. Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorganic & Medicinal Chemistry 2008 16(6):3032-3038. [Abstract] ( Exit NIEHS
  10. Ryu EK, Wu Z, Chen K, Lazarus LH, Marczak ED, Sasaki Y, Ambo A, Salvadori S, Ren C, Zhao H, Balboni G, Chen X. Synthesis of a Potent and Selective (18)F-Labeled delta-Opioid Receptor Antagonist Derived from the Dmt-Tic Pharmacophore for Positron Emission Tomography Imaging. Journal of Medicinal Chemistry 2008 51(6):1817-1823. [Abstract] ( Exit NIEHS
  11. Li T , Shiotani K, Miyazaki A, Tsuda Y, Ambo A, Sasaki Y, Jinsmaa Y, Marczak E, Bryant SD, Lazarus LH , Okada Y. Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands. Journal of Medicinal Chemistry 2007 50(12):2753-2766. [Abstract] ( Exit NIEHS

For an extensive list of the group’s publications, please see Lawrence Lazarus’ Curriculum Vitae (  Download Adobe Reader. Department of Health & Human Services National Institutes of Health
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Last Reviewed: January 12, 2009