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Selected Publications

Environmental Systems Biology Group


  • Gohlke, J.M., Armant, O., Parham, F.M., Smith, M.V., Zimmer, C., Castro, D.S., Nguyen, L., Parker, J.S., Gradwohl, G., Portier1, C.J., and Guillemot, F. (2008) Characterization of the proneural gene regulatory network during mouse telencephalon of development. BMC Biology 6: 15. [Abstract] ( Exit NIEHS


  • Barton, H.A., Chiu, W.A., Setzer, R.W., Andersen, M.E., Bailer, A.J., Bois, F.Y., Dewoskin, R.S., Hays, S, Johanson, G, Jones, N, Loizou, G, MacPhail, R.C., Portier, C.J., Spendiff, M, and Tan, Y-M. (2007) Characterizing uncertainty and variability in physiologically based pharmacokinetic models: State of the science and needs for research and implementation. Toxicological Sciences: An Official Journal of the Society of Toxicology 99(2): 395-402.
  • Gohlke, J.M. and Portier, C.J. (2007) The forest for the trees: a systems approach to human health research. Environ Health Perspect 115(9): 1261-3.
  • Buehler, M., Steiner, A., Meylan, M., . Portier, C.J, and Mevissen, M. (2007) In vitro effects of bethanechol on smooth muscle preparations from abomasal fundus, corpus, and antrum of dairy cows. Res Vet Sci.
  • Kissling, G.E., Portier, C.J., and Huff, J. (2007) MtBE and cancer in animals: Statistical issues with poly-3 survival adjustments for lifetime studies. Regul Toxicol Pharmacol.
  • Smith, M. V., Miller, C.R., Kohn, M., Walker, N.J. and Portier, C.J. (2007) Absolute estimation of initial concentrations of amplicon in a real-time RT-PCR process. BMC Bioinformatics 8: 409.


  • Toyoshiba, H., Sone, H., Yamanaka, T., Parham, F., Irwin, R., Boorman, G., and Portier, C. (2006) Gene network analysis suggests differences between high and low doses of acetaminophen. Toxicology and Applied Pharmacology 215 (3), 306-316.
  • Knobloch, M., Portier, C.J., Levionnois, O.L., Theurillat, R., Thormann, W., Spadavecchia, C., and Mevissen, M. (2006) Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion. Toxicology And Applied Pharmacology 216 (3): 373-386.
  • Becker, R.A., Borgert, C.J., Webb, S., Ansell, J., Amundson, S., Portier, C.J., Goldberg, A., Bruner, L.H., Rowan, A., Curren, R.D., and Stott, W.T. (2006) Report of an ISRTP workshop: progress and barriers to incorporating alternative toxicological methods in the U.S. Regul Toxicol Pharmacol. Oct;46(1):18-22.


  • Walker, N.J., Crockett, P.W., Nyska, A., Brix, A.E., Jokinen, M.P., Sells, D.M., Hailey, J.R., Easterling, M., Haseman, J.K., Yin, M., Wyde, M.E., Bucher, J.R., and Portier, C.J. (2005) Dose-additive carcinogenicity of a defined mixture of "dioxin-like compounds". Environ Health Perspect 113, 43-48.*
  • Boorman, G.A., Irwin, R.D., Vallant, M.K., Gerken, D.K., Lobenhofer, E.K., Hejtmancik, M.R., Hurban, P., Brys, A.M., Travlos, G.S., Parker, J.S., and Portier, C.J. (2005) Variation in the hepatic gene expression in individual male Fischer rats. Toxicol Pathol 33, 102-110.
  • Resnik, D. B., and Portier, C. (2005) Pesticide testing on human subjects: weighing benefits and risks. Environ Health Perspect 113, 813-817.


  • Toyoshiba, H., Walker, N.J., Bailer, A.J. and Portier, C.J. (2004) Evaluation of toxic equivalency factors for induction of cytochromes P450 CYP1A1 and CYP1A2 enzyme activity by dioxin-like compounds. Toxicol Appl Pharmacol, 194: 156-68.
  • Trachsel, D., Tschudi, P., Portier, C.J., Kuhn, M., Thormann, W., Scholtysik, G. and Mevissen, M. (2004) Pharmacokinetics and pharmacodynamic effects of amiodarone in plasma of ponies after single intravenous administration. Toxicology and Applied Pharmacology, 195, 113-125.
  • Bucher, J. R., and Portier, C. (2004) Human carcinogenic risk evaluation, Part V: The national toxicology program vision for assessing the human carcinogenic hazard of chemicals. Toxicol Sci 82, 363-366.
  • Germolec, D.R., Kashon, M., Nyska, A., Kuper, C.F., Portier, C., Kommineni, C., Johnson, K.A., and Luster, M.I. (2004a) The accuracy of extended histopathology to detect immunotoxic chemicals. Toxicol Sci 82, 504-514.
  • Germolec, D.R., Nyska, A., Kashon, M., Kuper, C.F., Portier, C., Kommineni, C., Johnson, K.A., and Luster, M.I. (2004b) Extended histopathology in immunotoxicity testing: interlaboratory validation studies. Toxicol Sci 78, 107-115.
  • Shelby, M., Portier, C., Goldman, L., Moore, J., Iannucci, A., Jahnke, G., and Donkin, S. (2004) NTP-CERHR expert panel report on the reproductive and developmental toxicity of methanol. Reprod Toxicol 18, 303-390.
  • Smith, M.V., Nyska, A., and Portier, C. (2004) Application of a statistical dynamic model investigating the short-term cellular kinetics induced by riddelliine, a hepatic endothelial carcinogen. Toxicol Sci 80, 258-267.
  • Toyoshiba, H., Yamanaka, T., Sone, H., Parham, F. M., Walker, N. J., Martinez, J., and Portier, C. J. (2004b) Gene interaction network suggests dioxin induces a significant linkage between aryl hydrocarbon receptor and retinoic acid receptor beta. Environ Health Perspect 112, 1217-1224.**
  • Yamanaka, T., Toyoshiba, H., Sone, H., Parham, F. M., and Portier, C. J. (2004) The TAO-Gen algorithm for identifying gene interaction networks with application to SOS repair in E. coli. Environ Health Perspect 112, 1614-1621.
  • Bucher, J and Portier, C. Human carcinogenic risk evaluation, Part V: The national toxicology program vision for assessing the human carcinogenic hazard of chemicals. Toxicol Sci. 2004 Dec;82(2):363-6.


  • Chhabra, R.S., Bucher, J.R., Wolfe, M. and Portier, C. (2003) Toxicity characterization of environmental chemicals by the US National Toxicology Program: an overview. Int J Hyg Environ Health, 206, 437-45.
  • Germolec, D.R., Nyska, A., Kashon, M., Kuper, C.F., Portier, C., Kommineni, C., Johnson, K.A. and Luster, M.I. (2003) Extended Histopathology in Immunotoxicity Testing: Interlaboratory Validation Studies. Toxicol Sci.
  • Kim, A.H., Kohn, M.C., Nyska, A. and Walker, N.J. (2003) Area under the curve as a dose metric for promotional responses following 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol Appl Pharmacol, 191, 12-21.
  • Koken, P.J., Piver, W.T., Ye, F., Elixhauser, A., Olsen, L.M. and Portier, C.J. (2003) Temperature, air pollution, and hospitalization for cardiovascular diseases among elderly people in Denver. Environ Health Perspect, 111, 1312-7.
  • Landi, M.T., Bertazzi, P.A., Baccarelli, A., Consonni, D., Masten, S., Lucier, G., Mocarelli, P., Needham, L., Caporaso, N. and Grassman, J. (2003) TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accident. Carcinogenesis, 24, 673-80.
  • Lucier, G.W. (2003) Book Review: Dioxins and Health, 2nd edition. Environ Health Perspect, Sep, A670.
  • Waters, M., Boorman, G., Bushel, P., Cunningham, M., Irwin, R., Merrick, A., Olden, K., Paules, R., Selkirk, J., Stasiewicz, S., Weis, B., Van Houten, B., Walker, N. and Tennant, R. (2003) Systems toxicology and the Chemical Effects in Biological Systems (CEBS) knowledge base. EHP Toxicogenomics, 111, 15-28.
  • Whitaker, S.Y., Tran, H.T. and Portier, C.J. (2003) Development of a biologically-based controlled growth and differentiation model for developmental toxicology. J Math Biol, 46, 1-16.


  • Bruno, M.E., Borchers, C.H., Dial, J.M., Walker, N.J., Hartis, J.E., Wetmore, B.A., Carl Barrett, J.C., Tomer, K.B. and Merrick, B.A. (2002) Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics. Arch Biochem Biophys, 406, 153-64.
  • Grassman, J., Needham, L., Masten, S., Patterson, D., Lucier, G. and Walker, N. (2002) Expression of cytochromes P4501A1, 1A2 and 1B1 are correlated with dioxin levels in human liver. Organohalogen Compounds, 59, 183-187.
  • Hauser, D.S., Mevissen, M., Weiss, R., Portier, C.J., Scholtysik, G., Studer, U.E. and Danuser, H. (2002) Effects of ketanserin and DOI on spontaneous and 5-HT-evoked peristalsis of the pig ureter in vivo. Br J Pharmacol, 135, 1026-32.
  • Kerr, M., Afshari, C.A., Bennett, L., Bushel, P., Martinez, J.M., Walker, N. and Churchill, G. (2002) Statistical Analysis of a Gene Expression Microarray Experiment with Replication. Statistica Sinaca, 12, 203-217.
  • Kim, A.H., Kohn, M.C., Portier, C.J. and Walker, N.J. (2002) Impact of physiologically based pharmacokinetic modeling on benchmark dose calculations for TCDD-induced biochemical responses. Regul Toxicol Pharmacol, 36, 287-96.
  • Kohn, M.C., Melnick, R.L., Ye, F. and Portier, C.J. (2002) Pharmacokinetics of sodium nitrite-induced methemoglobinemia in the rat. Drug Metab Dispos, 30, 676-83.
  • Kohn, M.C. and Melnick, R.L. (2002) Biochemical origins of the non-monotonic receptor-mediated dose-response. J Mol Endocrinol, 29, 113-23.
  • Kohn, M.C. (2002) Use of sensitivity analysis to assess reliability of metabolic and physiological models. Risk Anal, 22, 623-31.
  • 53.Kohn, M.C., Tohmaz, A.S., Giroux, K.J., Blumenthal, G.M., Feezor, M.D. and Millington, D.S. (2002) Robustness of MetaNet graph models: predicting control of urea production in humans. Biosystems, 65, 61-78.
  • Koo, J.W., Parham, F., Kohn, M.C., Masten, S.A., Brock, J.W., Needham, L.L. and Portier, C.J. (2002) The association between biomarker-based exposure estimates for phthalates and demographic factors in a human reference population. Environ Health Perspect, 110, 405-10.
  • Lucier, G. and Wanchoo, V. (2002) Intelligent solutions for radiology data management and storage. Health Manag Technol, 23, 20-3.
  • Martinez, J.M., Afshari, C.A., Bushel, P.R., Masuda, A., Takahashi, T. and Walker, N.J. (2002) Differential toxicogenomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin in malignant and nonmalignant human airway epithelial cells. Toxicol Sci, 69, 409-23.
  • Martinez, J.M., Afshari, C.A., Bushel, P.R., Masuda, A., Takahashi, T. and Walker, N.J. (2002) Gene expression profiling in TCDD-treated human lung cells. Organohalogen Compounds, 53, 320-323.
  • Melnick, R., Lucier, G., Wolfe, M., Hall, R., Stancel, G., Prins, G., Gallo, M., Reuhl, K., Ho, S.M., Brown, T., Moore, J., Leakey, J., Haseman, J. and Kohn, M. (2002) Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review. Environ Health Perspect, 110, 427-31.
  • Parham, F.M., Matthews, H.B. and Portier, C.J. (2002) A physiologically based pharmacokinetic model of p,p'-dichlorodiphenylsulfone. Toxicol Appl Pharmacol, 181, 153-63.
  • Portier, C.J. (2002) Comments on the International Symposium on Light, Endocrine Systems and Cancer. Neuroendocrinol Lett, 23 Suppl 2, 79-81.
  • Portier, C.J. (2002) Endocrine dismodulation and cancer. Neuroendocrinol Lett, 23 Suppl 2, 43-7.
  • Simmons, P.T. and Portier, C.J. (2002) Toxicogenomics: the new frontier in risk analysis. Carcinogenesis, 23, 903-5.
  • Walker, N.J. Tech.Sight. (2002) A technique whose time has come. Science, 296, 557-9.
  • Weiss, R., Mevissen, M., Hauser, D.S., Scholtysik, G., Portier, C.J., Walter, B., Studer, U.E. and Danuser, H. (2002) Inhibition of human and pig ureter motility in vitro and in vivo by the K(+) channel openers PKF 217-744b and nicorandil. J Pharmacol Exp Ther, 302, 651-8.
  • Whitaker, S.Y. and Portier, C. (2002) A controlled growth and differentiation model for non-monotonic dose-response. Human and Ecological Risk Assessment, 8, 1739-1755.
  • Wyde, M.E., Cambre, T., Lebetkin, M., Eldridge, S.R. and Walker, N.J. (2002) Promotion of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin and 17beta-estradiol in male Sprague-Dawley rats. Toxicol Sci, 68, 295-303.


  • Kohn, M.C. and Melnick, R.L. (2001) Physiological modeling of butadiene disposition in mice and rats. Chem Biol Interact, 135-136, 285-301.
  • Mevissen, M., Denac, H., Schaad, A., Portier, C.J. and Scholtysik, G. (2001) Identification of a cardiac sodium channel insensitive to synthetic modulators. J Cardiovasc Pharmacol Ther, 6, 201-12.
  • Portier, C.J. (2001) Linking toxicology and epidemiology: the role of mechanistic modelling. Stat Med, 20, 1387-93.
  • Portier, C. (2001) Chipping away at environmental health risk assessment. Risk Policy Report, 8, 37-38.
  • Timchalk, C., Walker, N.J., Mann, R.C. and Metting, F.B. (2001) The virtual body workshop: current and future application of human biology models in environmental health research. Environ Health Perspect, 109, 421-3.
  • Walker, N.J. (2001) Real-time and quantitative PCR: applications to mechanism-based toxicology. J Biochem Mol Toxicol, 15, 121-7.
  • Willems, B.A., Melnick, R.L., Kohn, M.C. and Portier, C.J. (2001) A physiologically based pharmacokinetic model for inhalation and intravenous administration of naphthalene in rats and mice. Toxicol Appl Pharmacol, 176, 81-91.
  • Wyde, M.E., Eldridge, S.R., Lucier, G.W. and Walker, N.J. (2001) Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced tumor promotion by 17 beta-estradiol in female Sprague--Dawley rats. Toxicol Appl Pharmacol, 173, 7-17.
  • Wyde, M.E., Wong, V.A., Kim, A.H., Lucier, G.W. and Walker, N.J. (2001) Induction of hepatic 8-oxo-deoxyguanosine adducts by 2,3,7,8-tetrachlorodibenzo-p-dioxin in Sprague-Dawley rats is female-specific and estrogen-dependent. Chem Res Toxicol, 14, 849-55.
  • Ye, F., Piver, W.T., Ando, M. and Portier, C.J. (2001) Effects of temperature and air pollutants on cardiovascular and respiratory diseases for males and females older than 65 years of age in Tokyo, July and August 1980-1995. Environ Health Perspect, 109, 355-9.

* Awarded outstanding published paper in 2005 by the Risk Assessment Specialty Section of the Society of Toxicology.
** Awarded outstanding published paper in 2004 by the Risk Assessment Specialty Section of the Society of Toxicology

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