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Selected Publications

Neuropharmacology Group

  1. Qian L, Wei S-J, Zhang D, Hu X, Xu Z, Wilson B, El-Benna J, Hong J-S, Flood PM. Potent anti-inflammatory and neuroprotective effects of TGFb1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia. Journal of immunology (Baltimore, Md. : 1950) 181(1):660-668, 2008. [Abstract] ( Exit NIEHS
  2. Block, M. Zecca, L. O’Callahan, J. and Hong, J.S.:Microglia-mediated neurotoxicity: uncovering the molecular mechanism. Nature Rev. Neurosci. 8:57-69, 2007.  [Abstract] ( Exit NIEHS
  3. Zhang, W., Wang, T., Liu, J., Wilson, B., Meng, Y., Ali, S., Kim, H., Zhang, W. and Hong, J. S.: 3-Hydroxy-morphinan, analog of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited dopaminergic neurodegeneration both in Vivo and in Vitro.FASEB J. 20:2496-2511, 2006.  [Abstract] ( Exit NIEHS
  4. Chen, P., Peng, G, Li, G., Yang, S., Wu, X., Wang, C., Wilson, B., Lu, R., Gean, P., Chuang, D. and Hong, J.S.: Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Mol. Psychiatry. 11: 1116-1125, 2006.  [Abstract] ( Exit NIEHS
  5. Zhang, W., Wang, T., Pei, Z., Meng, Y., Wu, X., Wilson, B., Zhang, W., Hong, J. S. and Zhang, J.: Aggregated a-synuclein activates microglia: a process leading to disease progression in Parkinson’s disease. FASEB J. 19: 533-542, 2005.  [Abstract] ( Exit NIEHS
  6. Qin, L., Block, M., Liu, Y., Bienstock, R., Pei, Z., Zhang, W., Wu, X., Wilson, B., Burka, T. and Hong, J. S.: Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress. FASEB J. 19: 550-557, 2005.  [Abstract] ( Exit NIEHS
  7. Zhang, W., Qin, L. Wang, T., Wei, S. Gao, H. Liu, J., Wilson, B., Liu, B., Zhang, W. Kim, H., and Hong, J. S.: 3-Hydroxy-morphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotxicity. FASEB J. 19: 395-397, 2005.  [Abstract] ( Exit NIEHS
  8. Qin, L., Liu, Y., Wang, T., Wei, S., Block, M., Wilson, B., Liu, B. and Hong, J.S.: NADPH oxidase mediates LPS-induced neurotoxicity and pro-inflammatory gene expression in activated microglia. J. Biol. Chem. 279:1415-1421, 2004.  [Abstract] ( Exit NIEHS
  9. Liu, B. and Hong, J.S.: Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. Environmental Health Perspective. 111: 1065-1073, 2003.  [Abstract] ( Exit NIEHS
  10. Gao, H. Liu, B. Zhang, W. and Hong, J.S.: Novel anti-inflammatory therapy for Parkinson’s disease. Trends in Pharmacol. Sci. 24:395-401, 2003.  [Abstract] ( Exit NIEHS
  11. Gao, H., Liu, B. and Hong, J.S.: Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J. Neurosci. 23: 6181-6187, 2003.  [Abstract] ( Exit NIEHS
  12. Gao, H., Hong, J.S., Zhang, W. and Liu, B. synergistic dopaminergic neurotxocity of pesticide rotenone and inflammagen LPS: relevance to the etiology of Parkinson’s disease. J. Neurosci. 23:1228-1236, 2003.  [Abstract] ( Exit NIEHS
  13. Liu, B. and Hong, J.S.: Role of microglial activation in inflammation-mediated neurodegenerative diseases: study of mechanism and strategies for therapeutic intervention. Perspective in Pharmacology, J. Pharma. Exp. Ther. 304: 1-7, 2003.  [Abstract] ( Exit NIEHS
  14. Gao. H., Jiang, J., Wilson, B., Zhang, W., Hong, J. and Liu, B.: Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J. Neurochem. 81: 1285-1297, 2002.  [Abstract] ( Exit NIEHS
  15. Gao, H., Hong, J.S., Zhang, W. and Liu, B.: Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J. Neurosci. 22: 782-790, 2002.  [Abstract] ( Exit NIEHS
  16. Liu, B., Qin, L., Yang, S., Wilson, B., Liu, Y. and Hong, J.S.: Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage. J. Pharm. Exp. Ther. 298: 1133-1141, 2001.  [Abstract] ( Exit NIEHS
  17. Kim, W.G., Wilson, B.C., Jeohn,G.H., and Hong J.S.: Differential susceptibility of neurons in different brain regions in lipopolysaccharide (LPS)-induced neurotoxicity. J. Neurosci. 20: 6309-6316, 2000.  [Abstract] ( Exit NIEHS

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