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Selected Publications

Eicosanoid Biochemistry Group

2003 - Present

  1. Baek, S.J., Wilson, L.C., Hsi, L.C., Eling, T.E. Troglitazone, a Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand, Selectively Induces the Early Growth Response-1 Gene Independently of PPARγ. J. Biol. Chem., 278: 5845-5853, 2003.  [Abstract] ( Exit NIEHS
  2. Newman, D., Morito, S., Koo, J.S., Kim, K., Baek, S.J., Eling, T., and Jetten, A.M. Differential Regulation of Nonsteroidal Anti-Inflammatory Drug-Activated Gene in Normal Human Tracheobronchial Epithelial and Lung Carcinoma Cells by Retinoids. Mol. Pharmacol., 63: 557-564, 2003.  [Abstract] ( Exit NIEHS
  3. Wilson, L.C., Baek, S.J., Call, A., Eling, T.E. Nonsteroidal Anti-Inflammatory Drug-Activated Gene (NAG-1) is Induced by Genistein Through the Expression of p53 in Colorectal Cancer Cells. Int. J. Cancer, 105: 747-753, 2003.  [Abstract] ( Exit NIEHS
  4. Nixon, J.B., Kamitani, H., Baek, S.J., Eling, T.E. Evaluation of Eicosanoids and NSAIDs as PPARγ Ligands in Colorectal Carcinoma Cells. Prostaglandins Leukot Essent Fatty Acids, 68: 323-330, 2003.  [Abstract] ( Exit NIEHS
  5. Amin, R., Kamitani, H., Sultana, H., Taniura, S., Islam, A., Sho, A., Ishibashi, M., Eling, T.E. and Watanabe, T. Aspirin and indomethacin exhibit antiproliferative effects and induce apoptosis in T98G human glioblastoma cells. Neurol Res., 25:370-376, 2003.  [Abstract] ( Exit NIEHS
  6. Bottone, Jr., F.B., Martinez, J.M., Collins, J.B., Afshari , C.A., and Eling,T.E. Gene Modulation by the Cyclooxygenase Inhibitor, Sulindac Sulfide, in Human Colorectal Carcinoma Cells: Possible Link to Apoptosis. J. Biol. Chem., 278:25790-25801, 2003.  [Abstract] ( Exit NIEHS
  7. Nixon, J.B., Kim, K., Lamb, P.W., Bottone, Jr., F.B. and Eling, T.E., 15-Lipoxygenase-1 has anti-tumorigenic effects in colorectal cancer. Prostaglandins. Leuk. Essent. Fatty Acids, 70, 7-15, 2004.  [Abstract] ( Exit NIEHS
  8. Lee, C., Jang, Y., Sun-Ju.Y, Her, Moon, Y., Baek, S., Eling, E. Nordihydroguaiaretic acid, an antioxidant, inhibits transforming growth factor-β activity through the inhibition of Smad signaling pathway. Exp. Cell Res.289: 335-341, 2003.  [Abstract] ( Exit NIEHS
  9. Bottone, Jr., F.B., Martinez, J.M., Alston-Mills, B. and Eling, T.E. Gene Modulation by Cox-1 and Cox-2 Specific Inhibitors in Human Colorectal Carcinoma Cancer Cells. Carcinogenesis, 25: 349-357, 2004.  [Abstract] ( Exit NIEHS
  10. Wang, T.,Qin, L., Liu,Y., Wilson, B., Eling, T.E., Langenbach, R., Taniura, S., and Hong, J. Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia. J. Neurochem. 88:939-947, 2004.  [Abstract] ( Exit NIEHS
  11. Baek, S., Kim, J., Nixon, J.B., DiAugustine, R.P. and Eling, T.E. Expression of NAG-1, a Transforming Growth Factor-β Superfamily Member, by Troglitazone Requires the Early Growth Response Gene, EGR-1. J. Biol. Chem. 279:6883-6892, 2004.  [Abstract] ( Exit NIEHS
  12. Jain AK, Moore SM, Yamaguchi K, Eling TE, Baek SJ. Selective Nonsteroidal Anti-inflammatory Drugs Induce Thymosin Beta-4 and Alter Actin Cytoskeletal Organization in Human Colorectal Cancer Cells. J Pharmacol. Exp Ther.311:885-91, 2004.  [Abstract] ( Exit NIEHS
  13. Baek SJ, Kim JS, Jackson FR, Eling TE, McEntee MF, Lee SHE Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Carcinogenesis: 25, 2425-2432, 2004.  [Abstract] ( Exit NIEHS
  14. Martinez JM, Baek SJ, Mays DM, Tithof PK, Eling TE, Walker NJ. EGR1 Is a Novel Target for AhR Agonists in Human Lung Epithelial Cells. Toxicol. Sci. 82: 429-435, 2004.  [Abstract] ( Exit NIEHS
  15. Ishibashi M, Bottone FG, Taniura S, Kamitani H, Watanabe T, and Eling TE, The Cyclooxygenase Inhibitor Indomethacin Modulates Gene Expression and Represses the Extracellular Matrix Protein Laminin γ1 in Human Glioblastoma Cells. Exp. Cell Res.302:244-252, 2005.  [Abstract] ( Exit NIEHS
  16. Kim JS, Yoon J, Kim JK, Baek SJ, Eling TE, Leeg WJ, Ryug J, Leea JG, Jong-Bum Yooa J. Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. Biochem Biophys. Res. Comm. 325:1298-1303,2004.  [Abstract] ( Exit NIEHS
  17. Yamaguchi, K., Lee, S., Eling, T., and Baek, S., Identification of Nonsteroidal Anti-Inflammatory Drug-activated gene (NAG-1) as a Novel Downstream Target of Phosphatidylinositol 3-Kinase/AKT/GSK-3β pathway. J. Biol. Chem. 279: 49617-49623, 2004.  [Abstract] ( Exit NIEHS
  18. Seung Joon Baek, Jong-Sik Kim, Scott M. Moore, Seong-Ho Lee, Jeanelle Martinez, and Thomas E. Eling, Cycloxygenase inhibitors induce the expression of the tumor suppressor gene, EGR-1 which results in the up-regulation of NAG-1, an anti-tumorigenic protein. Mol. Pharm: 67: 356-364, 2005.  [Abstract] ( Exit NIEHS
  19. Seung-Ho Lee, Jing-Sik Kim, Kiyoshi Yamaguchi. Thomas E. Eling and Seung Joon Baek. Indole-3-carbinol and 3,3’-diindolylmethane induce expression of NAG-1 in a p53-independent manner. Biochem. Biophy. Res. Comm. 328: 63-69, 2005.  [Abstract] ( Exit NIEHS
  20. Minsub Shim and Thomas E. Eling, PKC-dependent Regulation of NAG-1/PLAB/MIC-1 Expression in LNCaP Prostate Carcinoma Cells. J. Biol. Chem.280: 18636-18642, 2005.  [Abstract] ( Exit NIEHS
  21. Frank G. Bottone, Jr., Yuseok Moon, Jong Sik Kim, Brenda Alston-Mills, Minako Ishibashi, and Thomas E. Eling, The anti-invasive activity of Cox inhibitors are regulated by the transcription factor Activating Transcription Factor 3 (ATF3). Mol. Canc. Ther. 4: 693-703, 2005.  [Abstract] ( Exit NIEHS
  22. Jong-Sik Kim, Seung Joon Baek, Tina Sali and Thomas Eling. The conventional NSAID sulindac sulfide arrests ovarian cancer cell growth through NAG-1/MIC-1/GDF-15. Mole Can. Ther. 4: 487-493, 2005.  [Abstract] ( Exit NIEHS
  23. House RL, Cassady JP, Eisen EJ, Eling TE, Collins JB, Grissom SF, Odle J. Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. Physiol Genomics, 21:351-361, 2005.  [Abstract] ( Exit NIEHS
  24. Frank G. Bottone, Jr., Yuseok Moon, Brenda Alston-Mills, and Thomas E. Eling. Transcriptional Regulation of Activating Transcription Factor 3 (ATF3) Involves the Early Growth Response-1 (Egr-1) Gene. J. Pharmacol. Exp. Ther.315, 668-677, 2005.  [Abstract] ( Exit NIEHS
  25. Yuseok Moon, Wayne C. Glasgow and Thomas E. Eling, Curcumin suppresses interleukin 1β-mediated microsomal prostaglandin E synthase 1 (mPGES-1) by altering early growth response gene EGR-1 and other signaling pathways. J. Pharmacol. Exp Ther.315, 788-795, 2005.  [Abstract] ( Exit NIEHS
  26. Krishnamurthy Malathi, Jayashree Paranjapee, Elena Bulanova, Minsub Shim, Jeanna M. Guenther-Johnson,Thomas Eling, Bryan Williams and Robert H. Silverman, A transcriptional signaling pathway in IFN system mediated by 2’-5’-oligoadenylate activation of RNase L. Proc. Nat. Acad. Sci. 102, 14533-14538, 2005.  [Abstract] ( Exit NIEHS
  27. Kim, JS, Baek, SJ, Bottone, FG Jr, Sali, T, and Eling TE, Overexpression of 15-lipoxygenase-1 induces growth arrest through phosphorylation of p53 in human colorectal cells. Mol. Cancer Res 9, 511-517, 2005.  [Abstract] ( Exit NIEHS
  28. Yuseok Moon, Frank G. Bottone, Jr., Michael F. McEntee, and Thomas E. Eling, Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by Thrombospondin-1 via the early growth response gene, Egr-1. Mol Cancer Ther. 4,1551-8, 2005.  [Abstract] ( Exit NIEHS
  29. Ryuji Okazaki, Yuseok Moon, Toshiyuki Norimura, and Thomas Eling. Ionizing Radiation Enhances the Expression of the Nonsteroidal Anti-inflammatory Drug-Activated Gene (NAG1) by Increasing the Expression of TP53 in Human Colon Cancer Cells Radiation Res. 165, 125-130, 2006.  [Abstract] ( Exit NIEHS
  30. Lee SH, Yamaguchi K, Kim JS, Eling TE, Safe S, Park Y, and Baek SJ. Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis. 27:972-81, 2006.  [Abstract] ( Exit NIEHS
  31. Baek SJ and Eling TE. Changes in gene expression contribute to cancer prevention by COX inhibitors. Prog. Lipid Res. 45:1-16, 2006.  [Abstract] ( Exit NIEHS
  32. Martinez JM, Sali T, Okazaki R, Anna C, Hollingshead M, Hose C, Monks A, Walker NJ, Baek SJ, and Eling TE. Drug-induced expression of nonsteroidal anti-inflammatory drug-activated gene/macrophage inhibitory cytokine-1/prostate-derived factor, a putative tumor suppressor, inhibits tumor growth. J. Pharmacol. Exp Ther. 318:899-906, 2006.  [Abstract] ( Exit NIEHS
  33. Yamaguchi K, Lee SH, Eling TE, and Baek SJ. A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Mol Cancer Ther. 5:1352-61, 2006.  [Abstract] ( Exit NIEHS
  34. Lambert JR, Kelly JA, Shim M, Huffer WE, Nordeen SK, Baek SJ, Eling TE, and Lucia MS. Prostate derived factor in human prostate cancer cells: Gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth. J. Cell Physiol. 208 566-574, 2006.  [Abstract] ( Exit NIEHS
  35. Baek S, Okazaki R, Lee S, Martinez J, Kim J, Yamaguchi K,. Mishina Y, Martin D, Shoieb A, McEntee M, and Eling. T. Nonsteroidal anti-inflammatory drug activated gene-1 overexpression in transgenic mice suppresses intestinal neoplasia. Gastroenterology, 131(5): 1553-60, 2006.  [Abstract] ( Exit NIEHS
  36. Lee C., Bottone, F., Krahn,J., Li, L., Mohrenweiser,H., Cook, M., Petrovich, R., Bell, D., Eling,T., and Zeldin, D., Identification and Functional Characterization of Polymorphisms in Human Cyclooxygenase-1 (PTGS1), Pharmacogenetics and Genomics, 17(2): 145-60, 2007.  [Abstract] ( Exit NIEHS
  37. Kambe A., Iguchi G., Moon Y. Kamitani H., Watanabe, T. and Eling T. Suppression of the Prostaglandin EP4 Receptor Expression by Troglitazone requires Phosphorylated Sp-1. Cancer Research, Submitted.
  38. Eling TE, Baek SJ, Shim M, Lee CH. NSAID activated gene (NAG-1), a modulator of tumorigenesis. Journal of biochemistry and molecular biology 2006 39(6):649-655. [Abstract] ( Exit NIEHS
  39. Kambe A, Iguchi G, Moon Y, Kamitani H, Watanabe T, Eling TE. Regulation of EP4 expression via the Sp-1 transcription factor: Inhibition of expression by anti-cancer agents. Biomedica biochimica acta 2008 1783(6):1211-1219. [Abstract] ( Exit NIEHS
  40. Moon Y, Kim JI, Yang H, Eling TE. Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways. Life sciences 2008 82(11-12):591-599. [Abstract] ( Exit NIEHS
  41. Shim M, Eling TE. Vitamin E succinate (VES) induces NAG-1 expression in a p38 kinase-dependent mechanism. Molecular cancer therapeutics 2008 7(4):961-971. [Abstract] ( Exit NIEHS

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