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Selected Publications

Inositol Signaling Group

  1. Mitchell J, Wang X, Zhang G, Gentzsch M, Nelson DJ, Shears SB. (2008) An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function. Curr Biol. 18(20):1600-1605. [Abstract] ( Exit NIEHS
  2. Stiles AR, Qian X, Shears SB, Grabau EA. (2008) Metabolic and signaling properties of an Itpk gene family in Glycine max. FEBS Lett. 582:1853-1858. [Abstract] ( Exit NIEHS
  3. Choi K, Mollapour E, Choi JH, Shears SB (2008) Cellular energetic status supervises the synthesis of bis-diphosphoinositol tetrakisphosphate independently of AMP-activated protein kinase. Mol. Pharm. 74(2):527-536. [Abstract] ( Exit NIEHS
  4. Cho J, King J, Qian X, Harwood AJ, Shears SB. (2008) Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt. Proc. Natl. Acad. Sci. USA 105(16):5998-6003. [Abstract] ( Exit NIEHS
  5. Mitchell, J., Wang, X., Gentsch, M., Nelson, D.J. and Shears, S.B. (2008) An Expanded Biological Repertoire for Ins(3,4,5,6)P4 through its Modulation of ClC-3 Function. Current Biology 18: 1600-1605. [Abstract] ( Exit NIEHS
  6. Yang L, Reece JM, Cho J, Bortner CD, Shears SB. (2008) The nucleolus exhibits an osmotically regulated gatekeeping activity that controls the spatial dynamics and functions of nucleolin. J. Biol. Chem. 283(17):11823-11831. [Abstract] ( Exit NIEHS
  7. Chamberlain, P., Qian, X., Stiles, A.R., Cho, J., Jones, D., Lesley, S., Grabau, E.A., Shears, S. B. and Spraggon, G. (2007) Integration of inositol phosphate signaling pathways by ITPK1 J. Biol. Chem. 282 28117-28125. [Abstract] ( Exit NIEHS
  8. Brehm MA, Schenk TMH, Zhou X, Fanick W, Lin H, Windhorst S, Nalaskowski MM, Kobras M, Shears SB, Mayr GW. (2007) Intracellular localization of human Inositol 1,3,4,5,6-pentakisphosphate 2-kinase. Biochem. J. 408(3):335-345. [Abstract] ( Exit NIEHS
  9. Choi JH, Williams J, Cho J, Falck JR, Shears SB. (2007) Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. J. Biol. Chem. 42: 30763-30775. [Abstract] ( Exit NIEHS
  10. Cho, J., Choi, K., Darden, T., Reynolds, P.R., Petitte, J.N., Shears, S.B. (2006) Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's "phosphate crisis”. J Biotechnol. 126: 248-59. [Abstract] ( Exit NIEHS
  11. Riley, A.M., Trusselle, M., Kuad, P., Borkovec, M., Cho, J., Choi, K., Qian, X., Shears, S.B., Spiess, B., Potter, B.V. (2006) Scyllo-inositol pentakisphosphate as an analogue of myo-inositol 1,3,4,5,6-pentakisphosphate: chemical synthesis, physicochemistry and biological applications. Chembiochem. 7: 1114-22. [Abstract] ( Exit NIEHS
  12. Pathogenicity of Salmonella: SopE-Mediated Membrane Ruffling is Independent of Inositol Phosphate Signals. Deleu, S., Reece, J.M. and Shears, S.B. (2006) FEBS Lett. 580 pp 1709-1715. [Abstract] ( Exit NIEHS
  13. Yang, L., Reece, J., Gabriel, S.E., Shears, S.B. (2006) Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis. J. Cell. Sci. 119 pp1320-1328. [Abstract] ( Exit NIEHS>
  14. Riley, A.M., Deleu, S., Qian, X., Mitchell, J., Chung, S.-K., Adelt, S., Vogel, G., Potter, B.V.L., Shears, S.B. (2006) On the contribution of stereochemistry to human ITPK1 specificity; Ins(1,4,5,6)P4 is not a physiologic substrate. FEBS Letters 580 324-330. [Abstract] ( Exit NIEHS
  15. Deleu, S., Choi, K., Pesesse, X., Cho, J., Sulis, M.L., Parsons, R., Shears, S.B. (2006) Physiologically-relevant levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P5 pool. Cellular Signalling 18 488-498. [Abstract] ( Exit NIEHS
  16. Shears, S.B. (2005) Can intervention in inositol phosphate signalling pathways improve therapy for cystic fibrosis? Expert Opin Ther Targets. 9 1307-1317. [Abstract] ( Exit NIEHS
  17. Shears, S.B. (2005) Rounding up the usual suspects: protein kinases as therapeutic targets. Drug Discov Today 10 240-242. [Abstract] ( Exit NIEHS
  18. Shears, S.B. (2005) Telomere maintenance by intracellular signals: new kid on the block? Proc. Natl. Acad. Sci. USA 102 1811-1812. [Abstract] ( Exit NIEHS
  19. Ribeiro, C.M., Paradiso, A.M., Carew, M.A., Shears, S.B., Boucher, R.C. (2005) Cystic fibrosis airway epithelial Ca2+ signaling. The mechanism for the larger agonist-mediated Ca2+ signals in human cystic fibrosis airway epithelia. J. Biol. Chem. 260, 10202-10209. [Abstract] ( Exit NIEHS
  20. Choi, K., Mollapour-Bever, E. and Shears, S.B. (2005) Signal transduction during environmental stress: InsP8 operates within highly restricted contexts. Cellular Signalling. 17, 1533-1541. [Abstract] ( Exit NIEHS
  21. Qian, X., Mitchell, J.J., Wei, S.J., Williams, J., Petrovich, R.M., and Shears, S.B. (2005) The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase. Biochem. J. 389, 389-395. [Abstract] ( Exit NIEHS
  22. Pesesse, X., Choi, K., Zhang, T. and Shears, S.B. (2004) Signaling by higher inositol polyphosphates. Synthesis of bisdiphosphoinositol tetrakisphosphate ("InsP8") is selectively activated by hyperosmotic stress. J. Biol. Chem. Accelerated Communication 279, 43378-43381. [Abstract] ( Exit NIEHS
  23. Chu,C., Alapat, D., Wen, X., Timo, K., Burstein, D., Lisanti, M., Shears, S. B., Kohtz, D. S. (2004) Ectopic expression of murine diphosphoinositol polyphosphate phosphohydrolase 1 attenuates signaling through the ERK1/2 pathway. Cellular Signalling 16 1045-1059. [Abstract] ( Exit NIEHS
  24. Shears, S.B. (2004) How versatile are inositol phosphate kinases? Biochem. J. 377 265-280. [Abstract] ( Exit NIEHS
  25. Hidaka, K., Kanematsu, T., Caffrey, J.J., Takeuchi, H., Shears, S.B., Hirata, H. (2003) The Importance to chondrocyte differentiation of changes in expression of the Multiple Inositol Polyphosphate Phosphatase. Exp. Cell Res. 290 254-264. [Abstract] ( Exit NIEHS
  26. Yu J., Leibiger B., Yang S.N., Caffery J.J., Shears S.B., Leibiger I.B., Barker C.J,. Berggren P.O. (2003) Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca2+ concentration. J. Biol. Chem. 278 46210-46218. [Abstract] ( Exit NIEHS
  27. Hua, L.V., Hidaka, K., Zhang, Pesesse, X., Barnes, L.D. Shears, S.B. (2003) Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases. Biochem. J. 373 81-89. [Abstract] ( Exit NIEHS
  28. Ho, M.W.Y., and Shears, S.B. (2002) Regulation of calcium-activated chloride channels by inositol 3,4,5,6-tetrakisphosphate. Current Topics in Membranes 53, 345-363.
  29. Hidaka K, Caffrey JJ, Hua L, Zhang T, Falck JR, Nickel GC, Carrel L, Barnes LD, Shears SB. (2002) An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. J. Biol. Chem. 277, 32730-32738. [Abstract] ( Exit NIEHS
  30. Renstrom E, Ivarsson R, Shears SB. (2002) Inositol 3,4,5,6-tetrakisphosphate inhibits insulin granule acidification and fusogenic potential. J. Biol. Chem. 277, 26717-26720. [Abstract] ( Exit NIEHS
  31. Dubois,E., Scherens B, Vierendeels F., Ho M.W.Y., Messenguy F., Shears S.B. (2002) In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis. J.Biol.Chem. 277, 23755-23763. [Abstract] ( Exit NIEHS
  32. Ho, M.W.Y., Yang, X., Carew, M.A., Zhang, T., Hua, L., Kwon, Y-U., Chung, S.K., Adelt, S., Vogel, G., Riley, A.M., Potter, B.V.L., Shears, S.B. (2002) Regulation of Ins(3,4,5,6)P4 Signaling by a Reversible Kinase/Phosphatase. Current Biology 12, 477-482. [Abstract] ( Exit NIEHS
  33. Adelt S, Plettenburg O, Dallmann G, Ritter FP, Shears SB, Altenbach H, Vogel G. (2001) Regiospecific phosphohydrolases from Dictyostelium as tools for the chemoenzymatic synthesis of the enantiomers D-myo-inositol 1,2,4-trisphosphate and D-myo-inositol 2,3,6-trisphosphate: non-physiological, potential analogues of biologically active D-myo-inositol 1,3,4-trisphosphate. Bioorg. Med. Chem. Lett. 11, 2705-2708. [Abstract] ( Exit NIEHS
  34. Liu C, Riley AM, Yang X, Shears SB, Potter BV. (2001) Synthesis and biological activity of D- and L-chiro-inositol 2,3,4,5-tetrakisphosphate: design of a novel and potent inhibitor of Ins(3,4,5,6)P4 1-kinase/Ins(1,3,4)P3 5/6-kinase. J Med Chem. 44 2984-2989. [Abstract] ( Exit NIEHS
  35. Abel K, Anderson RA, Shears SB. (2001) Phosphatidylinositol and inositol phosphate metabolism. J. Cell Sci. 114, 2207-2208. [Abstract] ( Exit NIEHS
  36. Kreda SM, Sumner M, Fillo S, Ribeiro CM, Luo GX, Xie W, Daniel KW, Shears S, Collins S, Wetsel WC. (2001) alpha(1)-Adrenergic Receptors Mediate LH-Releasing Hormone Secretion through Phospholipases C and A(2) in Immortalized Hypothalamic Neurons. Endocrinology 142, 4839-4851. [Abstract] ( Exit NIEHS
  37. Ho, M.W.Y., Kaetzel, M.A., Armstrong, D.L. and Shears, S.B. (2001) Regulation of a Human Chloride Channel: A Paradigm for Integrating Input from Calcium, CaMKII and Ins(3,4,5,6)P4. J. Biol. Chem. 276, 18673-18680. [Abstract] ( Exit NIEHS
  38. Caffrey, J.J., Darden, T., Wenk, M.R. and Shears, S.B. (2001) Expanding Coincident Signaling by PTEN through its Inositol 1,3,4,5,6-Pentakisphosphate 3-phosphatase Activity. FEBS Lett. 499, 6-10. [Abstract] ( Exit NIEHS
  39. Caffrey, J.J. and Shears, S.B. (2001) Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2. Gene 269, 53-60. [Abstract] ( Exit NIEHS
  40. Zhang, T., Caffrey, J.J. and Shears, S.B. (2001) The transcriptional regulator, Arg82, is a hybrid kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activity. FEBS Lett. 494, 208-212. [Abstract] ( Exit NIEHS
  41. Shears, S.B. (2001) Assessing the omnipotence of inositol hexakisphosphate. Cellular Signalling 13, 151-158. [Abstract] ( Exit NIEHS
  42. Zhou, D. Chen, L.-M. Hernandez, L., Shears, S.B. and Galán, J.E. (2001) A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization. Molecular Microbiology 39, 248-259. [Abstract] ( Exit NIEHS
  43. Dewaste, V., Pouillon, V., Moreau, C., Shears, S.B., Takazawa, K., Erneux, C. (2000) Cloning and expression of a cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase C. Biochem. J. 352, 343-351. [Abstract] ( Exit NIEHS
  44. Yang, X. and Shears, S.B. (2000) Multitasking in Signal Transduction by a Promiscuous Human Ins(3,4,5,6)P4 1-Kinase/Ins(1,3,4)P3 5/6-Kinase. Biochem. J. 351, 551-555. [Abstract] ( Exit NIEHS
  45. Chi, H., Yang, X., Kingsley, P.D., O'Keefe, R.J., Puzas, J.E., Rosier, R.N., Shears, S.B. and Reynolds, P.R. (2000) Targeted Deletion of Minpp1 Provides New Insight into the Activity of Multiple Inositol Polyphosphate Phosphatase. In Vivo. Mol. Cell. Biol. 20, 6496-6507. [Abstract] ( Exit NIEHS
  46. Carew, M.A., Yang, X. Schultz, C. and Shears, S.B. (2000)
    Ins(3,4,5,6)P4 inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell-line. J. Biol. Chem. 275, 26906-26913. [Abstract] ( Exit NIEHS
  47. Shears, S.B. (2000) Transcriptional Regulation: A new dominion for inositol phosphate signaling? Bioessays 22, 786-789. [Abstract] ( Exit NIEHS
  48. Saiardi, A., Caffrey, J.J., Snyder, S. H. and Shears, S. B. (2000) The Inositol Hexakisphosphate Kinase Family: Catalytic Flexibility, and Function in Yeast Vacuole Biogenesis. J. Biol. Chem. 275, 24686-24692. [Abstract] ( Exit NIEHS
  49. Caffrey, J.J., Safrany, S.T., Yang, X., and Shears, S.B. (2000) Discovery of Molecular and Catalytic Diversity Among Human Diphosphoinositol Polyphosphate Phosphohydrolases: An Expanding NUDT Family. J. Biol. Chem. 275, 12730-12736. [Abstract] ( Exit NIEHS
  50. Saiardi, A., Caffrey, J.J., Snyder, S. H. and Shears, S. B. (2000) Inositol Polyphosphate Multikinase (ArgRIII) Determines Nuclear mRNA Export in Saccharomyces cerevisiae. FEBS Lett. 468, 28-32. [Abstract] ( Exit NIEHS

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