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Selected Publications

Metabolism & Exposure Markers Group

  1. Simmonds, A.C, Reilly, C. A, Baldwin, R M., Ghanayem, B. I., Lanz, D L., Yost, G.S., Collins, K S., and Forkert, P-K. Bioactivation of 1,1-Dichloroethylene by CYP2E1 and CYP2F enzymes. Drug Metab. Disp. 32:1032-1039, 2004.  [Abstract] ( Exit NIEHS
  2. Simmonds, A.C, Ghanayem, B.I., Sharma, A., Reilly, C.A., Brandie, M., Yost, G.S., and Forkert, P-K: Bioactivation of 1,1-Dichloroethylene by CYP2E1 and CYP2F2 in Murine Lung. J Pharmacol. Exp. Therap. 310:855-864, 2004.  [Abstract] ( Exit NIEHS
  3. Blaisdell, J., Mohrenweiser, H., Coulter, S., Ferguson, S.S., Chanas, B., Xi, T., Ghanayem, B. I., and Goldstein, J.A. Discovery of new potentially defective alleles on human CYP2C9. Pharmacogenetics 14:527-537, 2004.  [Abstract] ( Exit NIEHS
  4. El-Hadri L, Chanas B, and Ghanayem, B.I. Comparative metabolism of methacrylonitrile and acrylonitrile to cyanide using CYP2E1- and microsomal epoxide hydrolase- (mEH) null mice. Toxicol. Appl. Pharmacol. 205:116-125, 2005.  [Abstract] ( Exit NIEHS
  5. Hoffler U., Dixon D., Pedadda S., and Ghanayem B.I.: Inhibition of Urethane-Induced Genotoxicity and Cell Proliferation in CYP2E1-null Mice. Mutation Research: Fund. Molec. Mech. Mutag. 572:58:72, 2005.  [Abstract] ( Exit NIEHS
  6. Hoffler U. and Ghanayem B.I.: Increased Bioaccumulation Urethane in CYP2E1-/- Versus wild-type mice. Drug Metab. Disp. 33:1144:1150, 2005.  [Abstract] ( Exit NIEHS
  7. Ghanayem, B.I., Witt, K.L., El-Hadri, L., Hoffler, U., Kissling, G.E., Shelby, M.D., Bishop, J.B.: Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated mechanism. Biol. Reprod. 72:157-163, 2005.  [Abstract] ( Exit NIEHS
  8. Ghanayem, B.I., McDaniel, P.L., Churchwell, M. I. Twaddle, N. C., Snyder, R., Timothy R Fennell T R., and Daniel R. Doerge D R. Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts. Tox. Sci. 88:311-318, 2005.  [Abstract] ( Exit NIEHS
  9. Ghanayem B.I., Witt KL, Kissling GE, Tice RR, Recio L. Absence of acrylamide-induced genotoxicity in CYP2E1-null mice. Mutation Research: Fund. Molec. Mech. Mutag. 578:284-297, 2005.  [Abstract] ( Exit NIEHS
  10. Lee, Su-Jen, Bell, D. A., Coulter, S.J., Ghanayem, B.I., and Goldstein, J.A. Recombinant CYP3A4*17 is defective in metabolizing the hypertensive drug nifidepine, and the CYP3A4*17 allele may occur on the same chromosome as CYP3A5*3, representing a new putative defective CYP3A halotype. J. Pharmacol. Exp. Therap. 313:302:309, 2005.  [Abstract] ( Exit NIEHS
  11. Forkert, P-K, Millen, B., Lash, L H., Putt, D. A., and Ghanayem, B.I. Pulmonary Bronchiolar Cytotoxicity and Formation of Dichloroacetyl Lysine Protein Adducts in Mice Treated with Trichloroethylene. J Pharmcol. Exp. Therap. 316:520-529, 2006.  [Abstract] ( Exit NIEHS
  12. Kim, D. and Ghanayem, B.I. Comparative metabolism and disposition of trichloroethylene in Cyp2e1-/- and Wild-Type Mice. Drug Metabolism and Disposition 34:2020-2027, 2006.  [Abstract] ( Exit NIEHS
  13. Ghanayem, B.I. Inhibition of Urethane-Induced Carcinogenicity in Cyp2e1-/- in Comparison to Cyp2e1+/+ Mice. Toxicol. Sci. 95:331-339, 2007.  [Abstract] ( Exit NIEHS
  14. Garner, C, Sloan, C, Burgess, J, Davis, J, Etheridge A, Parham, A. and Ghanayem B.I. CYP2E1-Mediated Oxidation Contributes to the Metabolism and Sperm Toxicity of 1-Bromopropane in Mice. Biol. Repr. 76:496-505, 2007.  [Abstract] ( Exit NIEHS
  15. Ghanayem BI, Hoffler U. Investigation of xenobiotics metabolism, genotoxicity, and carcinogenicity Using Cyp2e1-/- mice. Current drug metabolism 8(7):728-749, 2007. [Abstract] ( Exit NIEHS

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